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Oncolog, Volume 35, Number 01, January-March 1990, Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Is Malpractice Litigation Undermining Informed Consent?
• Total Parenteral Nutrition: The Double-Edged Sword
• Expandable Stents Provide Relief for Patients with Tumor-Compressed Tissue

Rubella Susceptibility And Continuing Risk Of Infection In Pregnancy, Saadiya Rasul, Mohammad Khurshid, Javaid Rizvi, Shahbanu Rizvi

Section of Haematology/Oncology

Sera of 2000 pregnant women attending the antenatal clinic of the Aga Khan University Hospital were tested for rubella antibodies. Of these 1684(84.2%) were Immune and 316(15.8%) were susceptible to rubella. Majority (99.8%) of the women were Asian in origin. Susceptibility decreased with increasing age and parity. We conclude that apart from vaccination of all young children greater attention should be paid to immunization of women of child-bearing age

A Phase Ii Trial Of Murine Monoclonal Antibody 17-1a And Interferon-Γ: Clinical And Immunological Data, Mansoor Saleh, Albert Lobuglio, Richard Wheeler, Kimberly Rogers, Amy Haynes, Jeannette Lee, M B. Khazaeli

Haematology and Oncology, East Africa

A group of 15 patients with metastatic colorectal adenocarcinoma received a combination of interferon γ (0.1 mg/m², days 1–15) and the murine monoclonal antibody 17-1A (400 mg, days 5, 7, 9 and 12). The treatment was tolerated with minimal toxicity. Of the 14 evaluable patients, 13 developed human antibody to murine 17-1A, with 11 patients demonstrating antibody to the variable region of 17-1A (anti-idiotype). Antibody to the variable region was inhibited by 17-1A but not by mouse immunoglobulin. Sera from patients with substantial anti-idiotype reactivity were capable of inhibiting the binding of murine 17-1A to antigen expressing LS174-T …

In Vitro Evaluation Of Cancer Patient Immune Responses Following Infusion Of Radiolabeled Murine Monoclonal Antibody, Kelly A. King

Loma Linda University Electronic Theses, Dissertations & Projects

Several monoclonal antibody (MAb) types derived from mice have been developed specifically for the use of targeting human tumors. The specificity of these murine MAb’s for their respective tumor antigens is very high making them potentially good immunotherapeutic agents for cancer treatment and diagnosis. A limiting factor in using these murine MAb’s in patients is the development of human anti-mouse antibody (HAMA). The presence of HAMA may reduce the effectiveness of MAb for tumor targeting. If patient sensitization could be quickly detected following the initial infusion of MAb, then future infusion could be altered or terminated to prevent further sensitization. …

Hypoxanthine-Induced Differentiation Of Cultured Human Leukemia Cells, Gayle Jennette Singleton

Chemistry & Biochemistry Theses & Dissertations

Human cultured leukemia cells appear to have a decreased amount of inosine in their tRNA. When cells with inosine deficient tRNA are placed in a hypoxanthine fortified media, they incorporate hypoxanthine into their tRNA by the action of the enzyme tRNA-hypoxanthine ribosyl transferase. This generates the nucleoside inosine in the tRNA. The cultured human leukemia cell lines, CCRF-CEM, HL-60, and HGPRT(-) HL- 60, incorporate hypoxanthine into their tRNA, as determined by tRNA isolation, hydrolysis, and HPLC analysis. Hypoxanthine treatment dramatically inhibited cell growth in conjunction with partial induction of differentiation in the CCRF-CEM, HL-60, and HGPRT ( - ) HL-60 …

Oncolog, Volume 34, Number 04, October-December 1989, Gabriel N. Hortobagyi Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• For Cancer Patients, Home May Be Their Hospital
• Neoadiuvant Chemotherapy for Patients with Stage III Breast Cancer
• Newer Methods of Delivery To Enhance GI Cancer Treatment

Oncolog, Volume 34, Number 03, July-September 1989, Stephen L. Huber Ms, Nicky Dozier Pharmd, Naguib A. Samaan Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Understanding Dose Intensity is Essential for Optimizing Chemotherapeutic Regimens
• Dysplastic Nevus Syndrome Identifies Patients at High Risk for Melanoma
• Multiple Endocrine Neoplasia Syndromes

Oncolog, Volume 34, Number 02, April-June 1989, Vicki Huff Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Bone Marrow Transplantation Supports Patients through High-Dose Chemotherapy
• Genetic Linkage Analysis of Familial Wilms' Tumor
• Osteosarcoma: Expandable Prostheses and Allografts Reduce the Need for Amputation

Oncolog, Volume 34, Number 01, January-March 1989, Mark S. Roh Md, Lillian M. Fuller Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Treatment Options for Colorectal Liver Metastases
• Improved Treatments for Non-Hodgkin's Lymphoma
• Early Discharge for Mastectomy Patients Does Not Increase Morbidity

Efficacy Of A Home Made Quality Control Serum, Rukbsana Lalani, Ayesha Molla, Mohammad Khurshid

Section of Haematology/Oncology

With increasing automation in Clinical Laboratories, the requirements for quality control material have greatly increased in order to monitor performance. The constant use of commercial control material is not economically feasible for many countries because of non-availability or the high cost of these materials. Here we describe a simple technique to prepare Home Made Quality Control serum using blood from polycythaemic patients. This preparation is stable for about six months without any alterations in the concentration of any of the chemical constituents. Extensive use of Home Made Quality Control sera in our laboratories have saved about 69% of the amount …

Quinidine-Induced Immune Thrombocytopenia, Mansoor Saleh, Nadhav Dhodaphar, Karren Allen, Albert Lobuglio

Haematology and Oncology, East Africa

D rugs may cause thrombocytopenia by three principal mechanisms: suppression of platelet production, direct platelet toxicity, or antibody-mediated platelet destmction (1). With the advent of assays specifically capable of detecting and quantifying IgG on the platelet surface (2), it has become increasingly possible to recognize cases of drug-induced immune thrombocytopenia based on the detection of elevated levels of platelet surface bound IgG in association with ingestion of causative dmgs. Consequendy, dmg-induced immune thrombocytopenia is no longer a disease diagnosed primarily by exclusion. The occurrence of quinidine-induced thrombocytopenia, though uncommon, was documented as early as 1965 (3) and has been thought …

Effect Of Intravenous Gammaglobulin On Circulating And Platelet-Bound Antibody In Immune Thrombocytopenia, G Garbano, Mansoor Saleh, P G. Mori, A F. Lobuglio, D Shaw

Haematology and Oncology, East Africa

Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects …

Dietary And Hormonal Evaluation Of Men At Risk For Prostate Cancer, Donald J. Pusateri

Loma Linda University Electronic Theses, Dissertations & Projects

Relationships between dietary nutrients and plasma and fecal estrone, estradiol-17β, testosterone, and plasma prolactin levels were studied in young Seventh-day Adventist men: 18 nonvegetarians (NV), 20 lacto-ovovegetarians (LOV), and 15 vegans (V). Blood samples and 3 d dietary records were obtained. Contemporaneously collected diet composites and stool samples were analyzed for fiber. The vegetarians consumed significantly more fiber than the omnivores, while NVs and LOVs consumed more saturated fat than the Vs. Although plasma steroid hormone status did not differ, the Vs had significantly higher fecal estrogen levels than the NVs or LOVs. Plasma prolactin levels were significantly higher in …

Population Amalgamation And Genetic Variation: Observations On Artificially Agglomerated Tribal Populations Of Central And South America, R Chakraborty, P E Smouse, J V Neel

Faculty, Staff and Student Publications

The interpretation of data on genetic variation with regard to the relative roles of different evolutionary factors that produce and maintain genetic variation depends critically on our assumptions concerning effective population size and the level of migration between neighboring populations. In humans, recent population growth and movements of specific ethnic groups across wide geographic areas mean that any theory based on assumptions of constant population size and absence of substructure is generally untenable. We examine the effects of population subdivision on the pattern of protein genetic variation in a total sample drawn from an artificial agglomerate of 12 tribal populations …

Oncolog, Volume 33, Number 03, July-September 1988, C. Stratton Hill, Jr. Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Narcotics and Cancer Pain Control
• For Non-small Cell Lung Cancer, Combinations of Surgery, Chemotherapy, and Radiotherapy
• Shared Research Resources Provide Expertise and Cost Savings

Oncolog, Volume 33, Number 01, January-March 1988, Michael J. Wargovich Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Portable Pumps and Controlled Drug Toxicity Keep More Patients Ambulatory and at Home
• Clarifications of Tumor Cell Diversification Bring New Ideas for Stopping the Process
• Chemoprevention of Colorectal Cancer

Oncolog, Volume 33, Number 04, October-December 1988, Oncolog Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Neodymium: YAG Laser Therapy for Palliative Treatment of Penile Kaposi's Sarcoma
• Knowing How Normal Cells Differentiate Will Add Rationality to Stopping Cancer Cells
• New Range of Fungal Infections Seen in Cancer Patients

Oncolog, Volume 33, Number 02, April-June 1988, David M. Gershenson Md, Saroj Vadhan-Raj Md, Kathryn F. Kennedy, Wayne L. Dorris Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Epithelial Ovarian Cancer: Treatment Has Improved, But Not Enough
• The Psychosocial Impact of Cancer and the Role of Social Work
• Hematopoiesis in Myelodysplastic Syndromes Improves with Granulocyte-Macrophage Colony-Stimulating Factor

Anaemia In Pregnancy: Occurrence In Two Economically Different Clinic Populations Of Karachi, Saadiya Aziz Karim, Mohammad Khurshid, Javed H. Rizvi

Section of Haematology/Oncology

According to previous WHO standards, anaemia in pregnancy denoted a haemoglobin level of 11.0 gms/dl or less, but this is now considered to be variable¹ as it differs from country to country depending on local reference ranges and socio-economic conditions. Each country should “lay down minimal acceptable standards” below which an individual is considered to be anaemic, taking into account the available fmancial and manpower resources and other health needs of the country². There is a wide divergence in the quoted prevalence of anaemia in Pakistan and neigh­bouring countries.^3-6 This study was undertaken to determine a …

Oral Assessment Guide, June Eilers, Ann Berger

Guides and Handouts: College of Nursing

The Oral Assessment Guide (OAG) can be used by the clinician to evaluate changes in the oral cavity. The OAG is comprised of eight categories of mucositis assessment of the mouth on a scale of 1 to 3, with “1” indicating normal and “3” indicating breakdown or loss of function. The OAG has been validated and is reliable in the current published format. Permission is granted for use in the current format. Any modifications will require new testing for validity and reliability. The OAG has been widely used in cancer and other populations and published in professional journals and books.

Clinical Use Of A Standard Kit-Preparation Of Radiolabeled Monoclonal Antibody 96.5 In The Diagnostic Imaging Of Metastatic Melanoma., Mansoor Saleh, D M. Miller, L Peterson, C D. Russell, M W. Unger

Haematology and Oncology, East Africa

We studied the efficiency of a standard-kit preparation using 1 mg 111In-labeled 96.5 monoclonal antibody in combination with 19 mg of unlabeled antibody in the diagnostic imaging of 27 patients with documented metastatic melanoma. Twenty-three of 26 patients (88%) demonstrated immunoscintigraphic localization of tumor. Of 104 metastatic sites previously documented by conventional studies, 62 (60%) were identified by immunoscintigraphy. A total of 77 sites demonstrated localization of radiolabeled antibody. Fifty-four (70%) corresponded to known sites of disease; eight sites (10%) were "discovered" by immunoscintigraphy and subsequently confirmed by conventional studies; 15 imaged sites (20%) could not be confirmed by conventional …

Oncolog, Volume 32, Number 02, April-June 1987, Lillian M. Fuller Md, Gabriel Lopez-Berestein

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Limited Chemotherapy and Radiotherapy Effective in Stage I and II Hodgkin's Disease in Adults
• Gene Rearrangement May Affect Prognosis of Some Chronic Myelogenous Leukemia Patients
• Liposomal Antibiotic Better, Less Toxic Than Free Drug for Treating Fungal Infections

Oncolog, Volume 32, Number 04, October-December 1987, Cheryl Mokrzecky

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Patients with Highly Invasive Cutaneous Melanoma Need Selective, Focused Evaluations Before Surgery\
• Diagnostic Radiologists Use Expandable Metallic Stents for Symptom Relief in Selected Patients
• Nutritional and Psychological Aspects of Feeding Children Who Have Cancer
• Adjuvant Chemotherapy Improves Survival of Patients with Stage II and III Breast Cancer

Oncolog, Volume 32, Number 03, October - December 1987, Douglas E. Johnson Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Improved Survival Results from Early Detection and Diagnosis of Testicular Cancer
• Current Laboratory Research Modernizes Traditional Chinese Herbal Medicine
• Gastrointestinal Radiotherapy Team Creates Atmosphere of Comfort and Confidence for Patients

Oncolog, Volume 32, Number 01, January-March 1987, Lovell A. Jones Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Anderson Physicians Staff AIDS Hospital to Advance Treatment and Halt Disease Spread
• Counseling Patients with AIDS and ARC Begins with Unconditional Acceptance
• The Realities of Cancer in Minority Communities

Sprague-Dawley Rats Fed Milk Or Beef Protein : Differences In Response To 1,2-Dimethylhydrazine Carcinogenesis, Stanley W. L. Ng

Loma Linda University Electronic Theses, Dissertations & Projects

Colon cancer is responsible for a high percentage of cancer deaths in developing countries, and there is convincing epidemiological evidence that meat protein and fat in the diet increase the incidence of this form of cancer. An animal tumor model which has been used by many investigators interested in colon cancer is the 1,2-dimethylhydrazine (DMH)-rat or DMH-mouse tumor model. In previous work done in this laboratory the DMH-BALB/c mouse tumor model was used to compare the production of colon tumors in mice fed a diet using non-fat powdered milk as a source of protein with those in mice fed beef …

Low Toxicity Radiation Sensitizer, Barton L. Bergquist, James C. Chang

Patents (University of Northern Iowa)

This invention relates to cisplatin type fluorescently labeled compounds. In particular, the compounds are bis (5-aminofluorescein)-dichloroplatinum (II) or certain substituted analogues thereof. The compounds are useful as radiation sensitivity enhancers and as fluorescent biological tracers. The invention also relates to a unique, single step synthesis for preparing said compounds.

Oncolog, Volume 31, Number 02, April-June 1986, Ralph S. Freedman Md, Phd, Elton Stubblefield Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Conference Report: Gynecologic Cancer Outcome Improves Because of New Treatment Applications
• A Geneticist's View of Cancer: New Insight from Developmental Mechanisms
• Counseling, Practical Advice Help Women with Cervical Cancer Resume Sexual Activity

Oncolog, Volume 31, Number 03, July-September 1986, Staff

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Learning How and Why Drugs Kill Cells Is Chemotherapy Researchers' Prime Goal
• Cancer Prevention Begins at Home: With MDA Screening and Detection Clinic
• Grant Taylor Organized First Collaborative Drug Research Group in This Part of the Country

Oncolog, Volume 31, Number 01, January-March 1986, Lester J. Peters Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• From Ability to Measure Cell Survival Come New Radiotherapeutic Strategies
• Diagnosing the Rare Lesion: Ovarian and Omental Ependymomas
• Radiotherapy Tailored to Patient's Disease