Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (15907)
- General Organization of Teaching Hospitals and Institutes (GOTHI) (510)
- Thomas Jefferson University (509)
- University of Kentucky (457)
- University of Nebraska - Lincoln (346)
-
- Lehigh Valley Health Network (263)
- LSU Health New Orleans (240)
- Roseman University of Health Sciences (186)
- Dartmouth College (179)
- University of Nebraska Medical Center (170)
- Children's Mercy Kansas City (148)
- Marshall University (145)
- JSS Academy of Higher Education and Research (139)
- Chapman University (131)
- Saudi Medical Journal (105)
- Himmelfarb Health Sciences Library, The George Washington University (98)
- Old Dominion University (80)
- Wayne State University (80)
- Valparaiso University (68)
- Aga Khan University (66)
- Zucker School of Medicine at Hofstra/Northwell (66)
- University of South Carolina (64)
- University of Texas Rio Grande Valley (59)
- Rowan University (58)
- City University of New York (CUNY) (55)
- Virginia Commonwealth University (51)
- HCA Healthcare (47)
- Providence (45)
- Ohio Northern University (44)
- University of Louisville (41)
- Keyword
-
- Humans (9996)
- Female (4020)
- Male (3422)
- Animals (3340)
- Mice (2390)
-
- Adult (1856)
- Middle Aged (1788)
- Aged (1535)
- Child (1190)
- Retrospective Studies (945)
- Neoplasms (844)
- Tumor (841)
- Adolescent (788)
- Mutation (708)
- Cell Line (655)
- Biomarkers (649)
- Carcinoma (646)
- Treatment Outcome (633)
- Cell Line, Tumor (608)
- United States (577)
- COVID-19 (576)
- Young Adult (540)
- Immunotherapy (536)
- Infant (531)
- Risk Factors (531)
- Receptors (519)
- Animal (489)
- Inbred C57BL (485)
- Child, Preschool (482)
- Mice, Inbred C57BL (478)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (8060)
- Faculty, Staff and Students Publications (6925)
- Journal of Medicine in Scientific Research (510)
- Children’s Nutrition Research Center Staff Publications (414)
- Nebraska Center for Virology: Faculty Publications (263)
-
- Duncan NRI Faculty and Staff Publications (259)
- Department of Medicine (232)
- Annual Research Symposium (185)
- School of Medicine Faculty Publications (178)
- Dartmouth Scholarship (177)
- Digital Journal of Clinical Medicine (139)
- Journal Articles: Pathology and Microbiology (123)
- Manuscripts, Articles, Book Chapters and Other Papers (108)
- Saudi Medical Journal (105)
- Sanders-Brown Center on Aging Faculty Publications (103)
- Dissertations and Theses (Open Access) (98)
- Department of Pathology, Anatomy, and Cell Biology Faculty Papers (93)
- Saha Cardiovascular Research Center Faculty Publications (93)
- Center on Aging Staff Publications (78)
- Pharmacy Faculty Articles and Research (74)
- Journal of Mind and Medical Sciences (68)
- Journal Articles (67)
- Microbiology, Immunology, and Tropical Medicine Faculty Publications (64)
- Clinical Practice in Athletic Training (58)
- School of Graduate Studies Faculty Publications (49)
- Biochemistry and Microbiology (48)
- Center for Medical Ethics and Health Policy Staff Publications (47)
- Food for Health: Publications (47)
- Markey Cancer Center Faculty Publications (46)
- Pharmacy and Wellness Review (43)
- Publication Type
Articles 21601 - 21601 of 21601
Full-Text Articles in Medical Specialties
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry
Nebraska Center for Virology: Faculty Publications
Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …