Medical Specialties Commons^™

Erratum: Implementation Of Ventilator Bundle For Prevention Of Ventilator‑Associated Pneumonia In Pediatric Intensive Care Unit, Alsoda Mf, Al‑Shahat Mm, Reda Sm, Alsawah Ay, Abboud Ma, Elgendy A, Hamouda Eid Ali Youssef El Gazzar

Journal of Medicine in Scientific Research

In the article titled "Implementation of ventilator bundle for prevention of ventilator‑associated pneumonia in pediatric intensive care unit", published on 10 February 2020, pages 265-72, Issue 2, Volume 4 of J Med Sci Res,[1] in the publish list of Author one more new author and affiliations is added as mentioned below:
"Mohamed F. Alsodaa, Mahmoud M. Al‑Shahatb, Sherif M.K. Redac, Ahmed Y. Alsawahc, Mohammad A.M. Abboudd, Abd‑Elaleem Elgendye, Hamouda Eid Ali Youssef El Gazzar
a Department of Pediatric and Neonatology, Ahmed Maher Teaching Hospital, Departments of e Clinical Pathology, c Pediatrics, d Diagnostic Radiology, Faculty of Medicine, Al‑Azhar University, Cairo, …

Protective Effect Of Some Plants Against The Toxicity Of Kidneys Caused By Gentamicin, Amal A. Salama, Asmaa S. Abd El-Wahed, Asmaa E. Mostafa

Journal of Medicine in Scientific Research

Objective The kidneys are a major organ for the removal of waste materials from the body. Plants play an essential role in human health. This work aimed to study the protective effect of some plants vs gentamicin toxicity of the kidneys. Materials and methods Thirty adult male albino rats (Sprague Dawley Strain) of weight 100±10 g were investigated. Rats were divided into two mean groups. Group 1 (six rats) was fed on a balanced diet and was present as a negative control for 4 weeks. Group 2 (24 rats) was injected with gentamicin 100 mg/kg BW/day for 8 days to …

Comparative Study Of Ginger (Zingiber Officinale Roscoe) As Raw And Herbal Tea: Microbiological, Mycotoxin, And Phytochemical Quality, Emad A. H. Guirguis

Journal of Medicine in Scientific Research

Background Ginger, commonly available as fresh rhizomes and dry powder, is prone to be contaminated either in spice or herbal tea form. Materials and methods Microbiological profile, total aflatoxin content, and phytochemical component were assessed using standard methods. Moreover, disc diffusion method was applied to investigate the antimicrobial ginger extract activity against foodborne pathogens. Results The most abundant identified compound was zingiberene in fresh (38.59%) and in dry powder (43.93%). The antimicrobial activity of ginger extract was more effective against gram-positive bacteria when compared with the results obtained by gram-negative bacteria. The microbiological quality revealed high contamination of dry samples …

Assessment Of Urinary Type Iv Collagen, Alpha-1 Microglobulin, And Transferrin In Type 2 Diabetes Mellitus With Nephropathy, Marwa E. Hassan, Mohamed H. Mahfouz, Mohamed S. Shoman

Journal of Medicine in Scientific Research

Aim The aim of this study was to assess the levels of urinary type IV collagen, alpha-1 microglobulin, and transferrin as risk factors for early detection of nephropathy progression in diabetic patients. Patients and methods Four groups (25 patients each) participated in this study. Group I: controls, group II: type 2 diabetes mellitus (T2DM) with normoalbuminuria [albumin creatinine ratio (ACR)<30 mg/g], group III: T2DM with microalbuminuria, and group IV: T2DM with macroalbuminuria (ACR≥300 mg/g). Urinary type IV collagen, alpha-1 microglobulin, and transferrin levels were measured using enzyme-linked immunosorbent assay. The levels of glucose, glycosylated hemoglobin, lipids, urea, creatinine, and microalbumin were also measured. Results Significant elevation of glucose and glycosylated hemoglobin, total cholesterol, triglycerides as well as low-density lipoprotein cholesterol, and a significant reduction of high-density lipoprotein cholesterol were reported in diabetic nephropathy as compared with the control group and normoalbuminuric group (P …

The Role Of Routine Abdominal Ultrasound In Newborns For Detection Of Renal Abnormalities, Hala N. I. Sahwan, Hamouda Eid Ali Youssef El Gazzar, Mohamed F. Alsoda, Mohammed A. S. Zannoun, Mostafa M. M. Shakweer, Salah Ibrahim, Wael Bahbah

Journal of Medicine in Scientific Research

Introduction Congenital and acquired renal diseases, which can produce renal insufficiency during the neonatal period, may be classified according to their ultrasonographic (US) characteristics: increased parenchymal echogenicity (renal parenchymal diseases, angiotensin-converting enzyme inhibitor fetopathy, and cortical necrosis), cystic disease (glomerulocystic kidney disease, autosomal recessive polycystic renal disease, multicystic dysplastic kidney, and cystic renal dysplasia), obstructive uropathies (ureteropelvic junction obstruction and posterior urethral valves), infections (candidal infections), and renal agenesis. The high-resolution sector and linear-array transducers allow the characterization of the underlying pathologic conditions in many cases. Findings of the renal parenchymal disease will vary on Doppler US, and during the …

Some Risk Factors For Neonatal Sensorineural Hearing Loss In A Neonatal Intensive Care Unit, Hamouda Eid Ali Youssef El Gazzar, Khaled H. Taman, Magdy K. Al, Mahmoud H. Dwabah, Mohamed F. Alsoda, Omar E. El Shourbagy

Journal of Medicine in Scientific Research

Background The sensorineural hearing loss incidence (SNHL) ranges from 1 to 3 per 1000 live births in term healthy neonates, and 2–4 per 100 in high-risk infants, a 10-fold increase. Objective The aim was to estimate the incidence of SNHL among newborns in NICU at Ahmed Maher Teaching Hospital, Cairo, Egypt, and to describe the distribution of risk factors associated with SNHL and the effects of their interaction. Patients and methods The study was carried out on 710 neonates in a hospital in Cairo, Egypt. A total of 710 (401 males and 309 females) neonates were included in the study …

Role Of Clarithromycin In Ventilator-Associated Pneumonia Care Bundle In The Prevention Of Ventilator-Associated Pneumonia, Ashraf A. H. Mahmoud, Wael A. E. El Hakeem

Journal of Medicine in Scientific Research

Objective The purpose of this study was to assess the efficacy of the addition of clarithromycin to the ventilator care bundle to help in the prevention of ventilator-associated pneumonia (VAP). Patients and methods Eighty patients of more than 18 years, on a mechanical ventilator for less than 48 h, expected length of stay in the ICU for more than 48 h, with no clinical and radiographic evidence of pneumonia were enrolled in a double-blind comparative study. The patients were randomized to one of the two groups: group A (n = 40) where the patients received clarithromycin (through the Ryle …

Effect Of Obturator Nerve Block During Transurethral Resection Of Lateral Bladder Wall Tumors: A Comparison Of Monopolar And Bipolar Tur-Bt Regarding The Presence Of Detrusor Muscle In Tumor Specimens And Recurrence Of Disease, Ehab Noh, Gamal E. Abourjila

Journal of Medicine in Scientific Research

Aim Any unintentional stimulation during electroresection results in adductor contraction and resultant sudden leg movement, which may in turn lead to perforation of bladder or incomplete resection. To avoid this reaction, obturator nerve block (ONB) and bipolar resection is effective to decrease the jerk. Patients and methods A prospective randomized, single-blind study was conducted during 2014–2018. A total of 74 patients were classified into four groups. Group I included 18 patients who received monopolar transurethral resection of bladder tumor (TUR-BT) and group II included 21 patients who received bipolar TUR-BT. Group III included 16 patients who received ONB and monopolar …

Martius Graft Transposition: A Successful Procedure For The Ultimate Repair Of The Anovaginal/Rectovaginal Fistula, Hossam H. Soliman, Mohamed A. Boghdady

Journal of Medicine in Scientific Research

Background Recto/ano-vaginal fistula (RAVF) is one of the worst medical conditions that could lead a lady to suffer in her life. It represents a horrendous experience that might put the lady suffering that ailment not only on the brink of abandoning her social life, but even disrupting her marital life and breaking the integrity of her family. There are various operative methods implemented all over the past decades aiming to cure such medical condition. Of those, interposing a vascularized tissue flap is suggested as an operative solution to guarantee long term successful healing. Of which the most commonly tried is …

Characteristics And Outcomes Of Mitral Valve Repair Surgery: A Single-Center Experience, Ashraf Zahra, Mohamed A. El-Hafez Fouly

Journal of Medicine in Scientific Research

Background The authors performed this retrospective study to report the experience of mitral valve repair (MVR) repair procedures, including the commonly used operative techniques and recorded outcomes. Patients and methods A total of 100 patients (76 males) who underwent MVR were enrolled in this study. Diagnosis was mainly based on detailed history taking along with an echocardiographic assessment. Data on preoperative, intraoperative, and postoperative variables were collected retrospectively from the database and patients' records. Missing data for particular outcomes were removed from the analysis. Results The four observed pathologies of the mitral valve [ischemic (67%), myxomatous (18%), postinfective (11%), and …

Double Valve Repair For Combined Aortic And Mitral Valve Regurgitation: Short-Term Results, Waleed El-Awady

Journal of Medicine in Scientific Research

Introduction Repair of mitral and aortic valve in double valve regurgitation is an attractive alternative to replacement, because of low incidence of valve-related complications. Standardization, reproducibility, and stable results are the three key points that will make any valve repair an established form. This study was undertaken to determine the short-term results of double valve repair for double regurgitation. Patients and methods Twenty-six patients had a double valve repair for aortic and mitral valve regurgitation. The mean age was 37.75 (14–53) years. There were 11 (42.3%) men and 15 (57.7%) women. The mean aortic cross-clamp time was 112 (86–135) min …

Myocardial Longitudinal Strain Reserve As A Marker Of Severity Of Coronary Artery Disease During Dobutamine Stress Echocardiography, Ahmed A. Aziz, Magdy M. Abdelsamie, Rania D. Aboushokka

Journal of Medicine in Scientific Research

Background Timely and prompt detection of coronary artery disease (CAD) is of paramount importance for patient management in daily clinical practice. Several noninvasive stress tests are available for evaluating CAD, of which dobutamine stress echocardiogram (DSE) is widely available for localization and extent of CAD. However, wall-motion analysis during DSE is subjective, so two-dimensional speckle tracking-derived longitudinal strain has been recently presented to allow quantitative assessment of global and regional wall motions. Aim To assess longitudinal strain reserve (LSR) during DSE test in predicting severity of CAD in chronic stable patients. Patients and methods The study included 48 patients with …

Rheumatic Mitral Valve Surgery In Low Ejection Fraction Patients, Ahmed M. Omran, Ahmed Kamel, Emad El Sarawy, Mohamed Roshdy

Journal of Medicine in Scientific Research

Objective Although, in Mitral valve disease, ischemic heart disease and degenerative etiology have the upper hand in developing countries, rheumatic fever still predominates in developing countries including Egypt. Due to delay presentation some patients had very low EF which made the surgery theoretically risky. Our study aims to emphasize the benefit of surgery in this group of patients. Patients and methods 100 consecutive patients with Inclusion criteria: Rheumatic Mitral valve disease +/- Tricuspid valve disease, aging 18 to 75 with Ejection Fraction< 35% Exclusion criteria: Non rheumatic etiology, associated Ischemic Heart Disease, other valvular lesions, redo cases and age less than 18. Results Mean age 49, 57 males, with mean Ejection Fraction 25%, Aortic Cross Clamp time 26 minutes, all …

Short-Term Outcome Of Onabotulinumtoxin A Injection For The Treatment Of Refractory Idiopathic Detrusor Overactivity, Amr M. Elsofy, Ayman M. Gabr, Gamal E. A. Abourjila, Khalid F. Elewa

Journal of Medicine in Scientific Research

Introduction There are many theories behind the etiology of refractory idiopathic detrusor overactivity (IDO), but it is generally accepted that it is caused by a combination of myogenic and neurogenic alterations. It is also believed that mucosal sensory systems make a significant contribution to the disorder as well. Intravesical botulinum toxin A (BoNT/A) prevents acetylcholine release at the neuromuscular junction, resulting in temporary chemodenervation and muscle relaxation. The aim of this work was to assessment of outcome of BoNT/A injection for the treatment of refractory IDO. Patients and methods The author included 37 patients who received intravesical BoNT/A for the …

The Struggling Infectious Diseases Fellow: Remediation Challenges And Opportunities, Michael T Melia, Armando Paez, Gail Reid, Lisa M Chirch, Vera P Luther, Brian G Blackburn, Federico Perez, Emily Abdoler, Daniel R Kaul, Susan Rehm, Nada Harik, Alice Barsoumian, Anna K Person, Heather Yun, J David Beckham, Susan Boruchoff, Paloma F Cariello, James B Cutrell, Christopher J Graber, Dong Heun Lee, Eileen Maziarz, Molly L Paras, Raymund R Razonable, Roseanne Ressner, Anne Chen, Brian Chow, Gerome Escota, Erica Herc, Andrew Johnson, Ryan C Maves, Obinna Nnedu, Heather Clauss, Prathit Kulkarni, Paul S Pottinger, Jose A Serpa, Tanaya Bhowmick, Marvin Bittner, Darcy Wooten, Beata Casanas, Rachel Shnekendorf, Emily A Blumberg

Faculty, Staff and Students Publications

Remediation of struggling learners is a challenge faced by all educators. In recognition of this reality, and in light of contemporary challenges facing infectious diseases (ID) fellowship program directors, the Infectious Diseases Society of America Training Program Directors' Committee focused the 2018 National Fellowship Program Directors' Meeting at IDWeek on "Remediation of the Struggling Fellow." Small group discussions addressed 7 core topics, including feedback and evaluations, performance management and remediation, knowledge deficits, fellow well-being, efficiency and time management, teaching skills, and career development. This manuscript synthesizes those discussions around a competency-based framework to provide program directors and other educators with …

Temporal Trends And Geographic Variations In Mortality Rates From Prescription Opioids: Lessons From Florida And West Virginia, Sarah A Palumbo, Charles H Hennekens, Janet D Robishaw, Robert S Levine

Faculty, Staff and Students Publications

OBJECTIVES: To explore temporal trends and geographic variations in mortality from prescription opioids from 1999 to 2016.

METHODS: Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research Multiple Cause of Death files were used to calculate age-adjusted rates and 95% confidence intervals (CIs) and create spatial cluster maps.

RESULTS: From 1999 to 2016, counties in West Virginia experienced the highest overall mortality rates in the United States from prescription opioids. Specifically, from 1999 to 2004, the highest rate in West Virginia of 24.87/100,000 (95% CI 17.84-33.73) was the fourth highest in the United States. From 2005 to …

Probable African Tick Bite Fever In The United States, Kami Lowery, Theodore Rosen

Faculty, Staff and Students Publications

African tick bite fever (ATBF) is a tick-borne rickettsial disease most often observed in North American and European tourists returning home from the southern portion of Africa. Ticks infected with Rickettsia africae transmit this parasitic bacterium to humans, who subsequently develop an influenza-like illness, one or more inoculation eschars, and in some cases, a cutaneous rash. Because ATBF often presents with non-specific symptoms that suggest other infectious diseases, establishing the diagnosis may be difficult. Confirmatory assays, including serology and nucleic acid amplification, may take weeks to return and cannot help with acute treatment decisions. We present a case of a …

Mail-Back Envelopes For Retrieval Of Opioids After Pediatric Surgery, Adam C Adler, Ammar N Yamani, Caitlin D Sutton, Danielle M Guffey, Arvind Chandrakantan

Faculty, Staff and Students Publications

BACKGROUND: Opioid overprescription has the potential to lead to harmful medications remaining in homes and to a rise in accidental or deliberate ingestion by children and adolescents. Although methods for opioid disposal are available, many are costly or require greater than minimal effort for the patient. In this study, we used a mail-back return envelope to retrieve unused opioids after ambulatory pediatric surgery.

METHODS: This feasibility study was performed to assess the rate of opioid return by using a mail-back envelope for children ages 0 to 18 prescribed opioids after outpatient surgery. Participants were provided a return envelope as well …

The Impact Of Diabetic Foot Ulcers And Unilateral Offloading Footwear On Gait In People With Diabetes, Erica Ling, Brian Lepow, He Zhou, Ana Enriquez, Ashley Mullen, Bijan Najafi

Faculty, Staff and Students Publications

BACKGROUND: Unilateral offloading footwear prescribed to patients with diabetic foot ulcers elevates one limb relative to the other, which may lead to limp and abnormal gait. This study investigated whether the unilateral foot ulcer and offloading combination negatively impacts gait function beyond diabetic peripheral neuropathy.

METHODS: Eighty-six participants were recruited in 3 groups: 12 with diabetic peripheral neuropathy and unilateral foot ulcers wearing offloading footwear (offloading group, age = 55.6 ± 9.5 years, BMI = 30.9 ± 4.5 kg/m

FINDINGS: The offloading group exhibited deteriorated gait function compared to the non-diabetic group (p < 0.005, Cohen's effect size d = 0.90-2.61). They also had decreased gait speed (p < 0.001, d = 1.79) and stride length (p < 0.001, d = 1.76), as well as increased gait cycle time (p < 0.001, d = 1.67) and limp (p < 0.050, d = 0.72-1.49) compared to the neuropathy group. The offloading group showed increased gait unsteadiness compared to the neuropathy group, but the difference did not reach statistical significance in our samples.

INTERPRETATION: This study demonstrated that while diabetic …

Safety And Efficacy Profile Of Ozenoxacin 1% Cream In Pediatric Patients With Impetigo, Adelaide A Hebert, Theodore Rosen, Núria Albareda López, Ilonka Zsolt, Xavier Masramon

Faculty, Staff and Students Publications

BACKGROUND: Ozenoxacin is a topical antibiotic approved in the United States for treatment of impetigo in adults and children age ≥2 months. This analysis evaluated the efficacy and safety of ozenoxacin in specific pediatric age groups.

METHODS: Data for children aged 2 months to <18 years recruited from eight countries who had participated in phase 1 and 3 trials of ozenoxacin were extracted and analyzed by age range.

RESULTS: Across studies, 644 pediatric patients with impetigo received ozenoxacin 1% cream (n = 287) or vehicle (n = 247). One study included retapamulin 1% ointment as the internal validity control (n = 110). The clinical success rate at the end of treatment and bacterial eradication rates after 3 to 4 days of treatment and at …

Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function In Mouse Hepatocytes, Sungwoo Choi, Bingning Dong, Chih-Chun Janet Lin, Mi Jeong Heo, Kang Ho Kim, Zhen Sun, Martin Wagner, Nagireddy Putluri, Jae Myoung Suh, Meng C Wang, David D Moore

Faculty, Staff and Students Publications

Liver receptor homologue-1 (LRH-1; NR5A2) is a nuclear receptor that regulates metabolic homeostasis in the liver. Previous studies identified phosphatidylcholines as potential endogenous agonist ligands for LRH-1. In the liver, distinct subsets of phosphatidylcholine species are generated by two different pathways: choline addition to phosphatidic acid via the Kennedy pathway, or trimethylation of phosphatidylethanolamine via Phosphatidylethanolamine N-methyl Transferase (PEMT). Here we report that a PEMT - LRH-1 pathway specifically couples methyl metabolism and mitochondrial activities in hepatocytes. We show that the loss of Lrh-1 reduces mitochondrial number, basal respiration, beta-oxidation and ATP production in hepatocytes, and decreases expression of mitochondrial …

Orthostatic Hypotension, Cardiovascular Outcomes, And Adverse Events: Results From Sprint, Stephen P Juraschek, Addison A Taylor, Jackson T Wright, Gregory W Evans, Edgar R Miller, Timothy B Plante, William C Cushman, Tanya R Gure, William E Haley, Imran Moinuddin, John Nord, Suzanne Oparil, Carolyn Pedley, Christianne L Roumie, Jeff Whittle, Alan Wiggers, Ciarán Finucane, Rose Anne Kenny, Lawrence J Appel, Raymond R Townsend

Faculty, Staff and Students Publications

Orthostatic hypotension (OH) is frequently observed with hypertension treatment, but its contribution to adverse outcomes is unknown. The Systolic Blood Pressure Intervention Trial (SPRINT) was a randomized trial of adults, age ≥50years at high risk for cardiovascular disease (CVD) with a seated systolic BP (SBP) of 130–180 mmHg and a standing SBP ≥110 mmHg. Participants were randomized to a SBP treatment goal of either <120 mmHg or <140 mmHg. OH was defined as a drop in SBP≥20 or diastolic BP ≥10 mmHg one minute after standing from a seated position. We used Cox models to examine the association of OH with CVD or adverse study events by randomized BP goal. During the follow-up period (median 3years), there were 1,170 (5.7%) instances of OH among those assigned a standard BP goal, and 1,057 (5.0%) among those assigned the intensive BP goal. OH was not associated with higher risk of CVD events (primary outcome: HR 1.06; 95%CI: 0.78,1.44). Moreover, OH was not associated with syncope, electrolyte abnormalities, injurious falls, or acute renal failure. OH was associated with hypotension-related hospitalizations or emergency department visits (HR 1.77; 1.11,2.82) and bradycardia (HR 1.94; 1.19,3.15), but these associations did not differ by BP treatment goal. OH was not associated with a higher risk of CVD events and BP treatment goal had no effect on OH’s association with hypotension and bradycardia. Symptomless OH during hypertension treatment should not be viewed as a reason to down-titrate therapy even in the setting of a lower BP goal.

Flying After Diving: Decompressions And Barotraumas., Nihad E. Daidzic

Aviation Department Publications

FAA Safety Seminar (GL1598968) held at Modern Avionics/Air Trek North at KFCM, Eden Prairie, MN at 9:00 CST on Saturday, February 29, 2020.

Adjuvant Therapy In Adrenocortical Carcinoma: Reflections And Future Directions, Sara Bedrose, Marilyne Daher, Lina Altameemi, Mouhammed Amir Habra

Faculty, Staff and Students Publications

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with high risk of recurrence despite macroscopically complete surgical resection. The main predictors of ACC recurrence include advanced disease stage, incomplete surgical resection, cortisol production, certain genetic alterations, and high proliferation rate (Ki-67 proliferation index). Mitotane has been the mainstay adjuvant therapy of ACC. However, the use of mitotane is based on retrospective and occasionally conflicting evidence. As mitotane levels can take a few months before reaching therapeutic levels, there is an emerging practice of combining platinum-based chemotherapy with mitotane in the adjuvant setting. Retrospective data indicate that radiotherapy is an …

Atypical Spindle Cell Lipomatous Tumor Under The Sesamoids In The Foot: A Case Report, Nilin M. Rao Dpm, Hani H. Saeed Dpm, Md, Facfas, Dustin Kruse Dpm, Bryan Raymond Dpm, Paul A. Stone Dpm, Facfas

Podiatry

Atypical spindle cell lipomatous (ASCL) tumors have a distinct histological and clinical presentation, rarely presenting in the foot. With the sub-sesamoidal location of this neoplasm found in our case report being an unusual location for atypical spindle cell lipomatous tumors to present, the purpose of our case report was to present the clinical presentation, histology/pathology, method of resection and outcome of our patient on follow-up to provide a framework for other surgeons on how to approach these neoplasms in the future.

Comparison Of Microneutralization And Histo-Blood Group Antigen-Blocking Assays For Functional Norovirus Antibody Detection, Robert L Atmar, Khalil Ettayebi, B Vijayalakshmi Ayyar, Frederick H Neill, Ralph P Braun, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

BACKGROUND: The development of an in vitro cultivation system for human noroviruses allows the measurement of neutralizing antibody levels.

METHODS: Serum neutralizing antibody levels were determined using a GII.4/Sydney/2012-like virus in human intestinal enteroids in samples collected before and 4 weeks after administration of an investigational norovirus vaccine and were compared with those measured in histo-blood group antigen (HBGA)-blocking assays.

RESULTS: Neutralizing antibody seroresponses were observed in 71% of 24 vaccinated adults, and antibody levels were highly correlated (r = 0.82, P < .001) with those measured by HBGA blocking.

CONCLUSIONS: HBGA-blocking antibodies are a surrogate for neutralization in human noroviruses.

A Decerebrating Female: A Rare Presentation Of Acute Disseminated Encephalomyelitis Due To Measles, Natasha Del Rio, Yordan Orive, Andres Sobrado, Ruben Cabrera, Ilde Manuel Lee, Troy Hoang, Sherard Lacaille, Ricardo Garcia-Rivera, Robert Hernandez

Internal Medicine

No abstract provided.

Multi-Domain Cognitive Assessment Of Male Mice Shows Space Radiation Is Not Harmful To High-Level Cognition And Actually Improves Pattern Separation, Cody W. Whoolery, Sanghee Yun, Ryan P. Reynolds, Melanie J. Lucero, Ivan Soler, Fionya H. Tran, Naoki Ito, Rachel L. Redfield, Devon R. Richardson, Hung-Ying Shih, Phillip D. Rivera, Benjamin P. C. Chen, Shari G. Birnbaum, Ann M. Stowe, Amelia J. Eisch

Neurology Faculty Publications

Astronauts on interplanetary missions - such as to Mars - will be exposed to space radiation, a spectrum of highly-charged, fast-moving particles that includes ⁵⁶Fe and ²⁸Si. Earth-based preclinical studies show space radiation decreases rodent performance in low- and some high-level cognitive tasks. Given astronaut use of touchscreen platforms during training and space flight and given the ability of rodent touchscreen tasks to assess functional integrity of brain circuits and multiple cognitive domains in a non-aversive way, here we exposed 6-month-old C57BL/6J male mice to whole-body space radiation and subsequently assessed them on a touchscreen battery. Relative to …

Expression Of Tryptophan 2,3-Dioxygenase In Metastatic Uveal Melanoma, Mizue Terai, Eric R Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, Takami Sato

Kimmel Cancer Center Faculty Papers

Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy. One of the mechanisms for resistance would be the immune-suppressive tumor microenvironment. Here, we have investigated the role of tryptophan 2,3-dioxygenase (TDO) in UM. Both TDO and indoleamine 2,3-dioxygenase (IDO) catalyze tryptophan and produce kynurenine, which could cause inhibition of T cell immune responses. We first studied the expression of TDO on tumor tissue specimens obtained from UM hepatic metastasis. High expression of TDO protein was confirmed in all …

Prostate Field Cancerization And Exosomes: Association Between Cd9, Early Growth Response 1 And Fatty Acid Synthase, Farideh Amirrad, Philip A. Pytak, Neda Sadeghiani-Pelar, Julie P. T. Nguyen, Emily L. Cauble, Anna C. Jones

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Intracapsular and well‑defined adenocarcinomas of the prostate are often surrounded by tissue areas that harbor molecular aberrations, including those of genetic, epigenetic and biochemical nature. This is known as field cancerization, or a field effect and denotes a state of pre‑malignancy. Such alterations in histologically normal tumor‑adjacent prostatic tissues have been recognized as clinically important and are potentially exploitable as biomarkers of disease and/or targets for preventative/therapeutic intervention. The authors have previously identified and validated two protein markers of field cancerization: The expressional upregulation of the transcription factor early growth response 1 (EGR‑1) and the lipogenic enzyme fatty acid synthase …