Medical Specialties Commons^™

Genomic Profiling For Clinical Decision Making In Myeloid Neoplasms And Acute Leukemia, Eric J Duncavage, Adam Bagg, Robert P Hasserjian, Courtney D Dinardo, Lucy A Godley, Ilaria Iacobucci, Siddhartha Jaiswal, Luca Malcovati, Alessandro M Vannucchi, Keyur P Patel, Daniel A Arber, Maria E Arcila, Rafael Bejar, Nancy Berliner, Michael J Borowitz, Susan Branford, Anna L Brown, Catherine A Cargo, Hartmut Döhner, Brunangelo Falini, Guillermo Garcia-Manero, Torsten Haferlach, Eva Hellström-Lindberg, Annette S Kim, Jeffery M Klco, Rami Komrokji, Mignon Lee-Cheun Loh, Sanam Loghavi, Charles G Mullighan, Seishi Ogawa, Attilio Orazi, Elli Papaemmanuil, Andreas Reiter, David M Ross, Michael Savona, Akiko Shimamura, Radek C Skoda, Francesc Solé, Richard M Stone, Ayalew Tefferi, Matthew J Walter, David Wu, Benjamin L Ebert, Mario Cazzola

Faculty, Staff and Student Publications

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic cells driven by somatic gene mutations. Although assessment of morphology plays a crucial role in the diagnostic evaluation of patients with these malignancies, genomic characterization has become increasingly important for accurate diagnosis, risk assessment, and therapeutic decision making. Conventional cytogenetics, a comprehensive and unbiased method for assessing chromosomal abnormalities, has been the mainstay of genomic testing over the past several decades and remains relevant today. However, more recent advances in sequencing technology have increased our ability to detect somatic mutations through the use of targeted gene panels, whole-exome …

Association Of Bradycardia And Asystole Episodes With Dialytic Parameters: An Analysis Of The Monitoring In Dialysis (Mid) Study, Qandeel H Soomro, Nisha Bansal, Wolfgang C Winkelmayer, Bruce A Koplan, Alexandru I Costea, Prabir Roy-Chaudhury, James A Tumlin, Vijay Kher, Don E Williamson, Saurabh Pokhariyal, Candace K Mcclure, David M Charytan, Mid Investigators

Faculty, Staff and Students Publications

BACKGROUND: Bradycardia and asystole events are common among patients treated with maintenance hemodialysis. However, triggers of these events in patients on maintenance hemodialysis (HD), particularly during the long interdialytic period when these events cluster, are uncertain.

METHODS: The Monitoring in Dialysis Study (MiD) enrolled 66 patients on maintenance HD who were implanted with loop recorders and followed for 6 months. We analyzed associations of predialysis laboratory values with clinically significant bradyarrhythmia or asystole (CSBA) during the 12 hours before an HD session. Associations with CSBA were analyzed with mixed-effect models. Adjusted negative binomial mixed-effect regression was used to estimate incidence …

Stakeholder Engagement In Eight Comparative Effectiveness Trials In African Americans And Latinos With Asthma, Tiffany Dy, Winifred J Hamilton, C Bradley Kramer, Andrea Apter, Jerry A Krishnan, James W Stout, Stephen J Teach, Alex Federman, John Elder, Tyra Bryant-Stephens, Rebecca J Bruhl, Shawni Jackson, Kaharu Sumino

Faculty, Staff and Students Publications

BACKGROUND: The effects of stakeholder engagement, particularly in comparative effectiveness trials, have not been widely reported. In 2014, eight comparative effectiveness studies targeting African Americans and Hispanics/Latinos with uncontrolled asthma were funded by the Patient-Centered Outcomes Research Institute (PCORI) as part of its Addressing Disparities Program. Awardees were required to meaningfully involve patients and other stakeholders. Using specific examples, we describe how these stakeholders substantially changed the research protocols and in other ways participated meaningfully as full partners in the development and conduct of the eight studies.

METHODS: Using the method content analysis of cases, we identified themes regarding the …

Clinicopathological And Prognostic Significance Of Cxcr4 Expression In Osteosarcoma: A Meta-Analysis, I Gusti Ngurah Ananda Wira Kusuma, Grace Yulia Alphani Yapson, John Nolan, I Gede Eka Wiratnaya, I Gede Putu Supadmanaba

BioMedicine

Background: The C-X-C Motif Chemokine Receptor (CXCR4) is an oncogene that has been widely studied and associated with worse clinicopathological features and prognosis outcomes in many types of cancer. Besides that, significance of CXCR4 expression on clinicopathological features and prognostic factors in osteosarcoma (OS) requires further validation.

Aim: We conducted a meta-analysis to evaluate the association between positive CXCR4 expression with clinicopathological features and prognosis in OS.

Methods: Literature searches on Pubmed, Cochrane Library, and Web of Science were conducted systematically up to December 2021 to find relevant references. The effects of CXCR4 expression on clinicopathological characteristics and prognostic were …

Study Of Arterial Blood Gases In Different Stages Of Chronic Liver Diseases, Moheb W. Elfaizy, Therese S. Ghatas

Journal of Medicine in Scientific Research

Background Early detection of arterial gas abnormalities and acid–base disturbances in patients with chronic liver disease is essential to improve prognosis on the basis of pulmonary and liver diseases. The aim of the current study was to detect arterial blood gas changes, acid–base disturbances, and prevalence of hepatopulmonary syndrome (HPS) in different classes of severity of chronic hepatic disease for achieving a higher survival rate. Results Patients with hypoxemia represented 38 (33.6%) cases: three (15.7%) of 19 patients in group A, 16 (33.3%) of 48 patients in group B, 12 (34.2%) of 35 patients in group C, and seven (63.6%) …

Short-Term Results Of Off-Pump And On-Pump Aortic Arch Debranching During Type I Hybrid Arch Repair: A Single-Center Experience, Ahmed S. Emara, Hussein A. Zaher, Mahmoud F. El-Safty, Mohamed A. El-Badawy, Mohamed A. El-Hady, Mostafa M. Abdalraouf

Journal of Medicine in Scientific Research

Background Compared with off-pump surgeries, cardiopulmonary bypass (CPB) is associated with a high systemic inflammatory response and with substantial myocardial injury, especially in high-risk subgroups. Every effort should be exerted to minimize the role of CPB without affecting the safety and outcome. Classically, aortic arch surgeries were done using CPB and deep circulatory arrest together with cerebral brain protection strategies. With the development of endovascular techniques, the role of CPB decreased. Management of aortic arch pathologies carries special needs, specifically rerouting of the great vessels and preparing a landing zone. Objectives To assess the effectiveness and safety of off-pump aortic …

Mitral Valve Repair For Mitral Regurgitation In Pediatrics And Children: Initial Experience, Waleed El-Awady

Journal of Medicine in Scientific Research

Introduction Mitral valve repair in pediatrics has been slow because of the great variety in congenital mitral valve malformations and the still unknown growing effect over the mitral valve. The aim of this study is to evaluate the early and mid-term results in surgical repair of mitral valve regurgitation in pediatrics and children. Patients and methods A total of 16 patients had mitral valve repair for mitral regurgitation (MR) between November 2016 and December 2020 at the National Heart Institute. There were seven (43.75%) males and nine (56.25%) females. The mean age was 7.5 years (5 months and 14 years). …

Fontan Procedure With Extracardiac Conduit In Pediatrics And Children: Short-Term Results, Amal Younan, Hanan Hassan, Waleed El-Awady

Journal of Medicine in Scientific Research

Introduction The concept of Fontan circulation was first clinically introduced in 1971. Technical modifications have been advocated with the concept of total cavopulmonary connection, introduced in the late 80s. Recently, an extracardiac conduit to divert inferior vena cava flow to the pulmonary arteries has been advocated, and it affords excellent palliation for patients with various forms of the anatomic or functional single ventricle. Patients and methods From September 2019 to August 2021, 12 patients (five males and seven females) with a mean age of 10.7 (6–15) years underwent a Fontan procedure with extracardiac conduit at the National Heart Institute. The …

Combined Macular Detachment And Macular Massage In Large Macular Hole, Hazem A. Elnashar

Journal of Medicine in Scientific Research

Background Over the past two decades, the surgical treatment of full-thickness macular holes (MHs) has advanced significantly, with current hole closure rate increasing more than 95%. Aim To assess the visual and anatomical outcomes of combined macular detachment and macular massage techniques for large MHs. Patients and methods The current work involved 12 eyes of 12 patients with large full-thickness idiopathic or traumatic MH. All participants were subjected to full ophthalmic assessment and measurement of best-correctable Snellen visual acuity, intraocular pressure, fundus photograph, and spectral-domain ocular coherence tomography at preoperative and postoperative periods. All surgeries were done by two surgeons …

Relation Of Multimineral-Vitamin D Supplementation And The Risk Of Preeclampsia, Abear El Shabacy, Mohamed A. El-Naggar, Mohamed S. A. Emarah, Osama S. Eltaher, Saher H. Qushwa

Journal of Medicine in Scientific Research

Background The objective of this study was to determine the favorable effects of multimineral-vitamin D supplementation on pregnancy outcomes among women at risk for preeclampsia. Patients and methods This randomized double-blind controlled clinical trial was conducted among 46 women at risk for preeclampsia at 27 weeks of gestation, with positive roll-over test. Pregnant women were randomly assigned to receive either the multimineral-vitamin D supplements (n = 23) or the placebo (n = 23) for 9 weeks. Multimineral-vitamin D supplements were containing 800 mg calcium, 200 mg magnesium, 8 mg zinc, and 400 IU vitamin D3. Fasting blood samples …

Role Of Vaginal Progesterone On Uterine Artery Doppler Changes In Pregnant Women At Risk Of Preterm Labor, Ahmed A. Badr, Ibrahim M. El-Maghraby

Journal of Medicine in Scientific Research

Background Progesterone is increasingly being used in women at high risk for preterm labor and for maintenance tocolysis. Ultrasound evaluation of uterine in pregnant women in the second trimester of pregnancy can be a predictor of birth complications. Objective To study the effect of vaginal progesterone on uterine by doppler sonography among women in the second and third trimesters of pregnancy who are at risk of preterm labor. Patients and methods A prospective study was carried out on 60 patients attending Obstetrics and Gynecology Department, Menoufia Teaching Hospital, Menoufia, Egypt, during the period from March 2019 to March 2020. The …

C-Reactive Protein In View Of Prognosis In Sepsis, Ashraf A.H Mahmoud Soliman, Raghad S. Abdellatif, Wael A. E. El Hakeem

Journal of Medicine in Scientific Research

Introduction Sepsis is the host reaction to invading microbes. The septic response generally occurs when immune defenses fail to contain an invading microbe and may also be induced by microbial exotoxins. C-reactive protein (CRP) is an acute-phase protein in humans and an important component of the innate immune system. CRP activates complement's classical route, which is one of its key strategies for defending the host. Patients and methods This study was conducted on 20 patients with systemic sepsis and admitted to the critical care unit; moreover, 20 healthy participants were studied as a control group. Results Both groups were matched …

The Role Of Sildenafil In Perioperative Management Of Patients With Pulmonary Hypertension Undergoing Lower Limb Vascular Surgery, Ashraf A.H M. Soliman, Wael Abd Elateif El Hakeem

Journal of Medicine in Scientific Research

Objective To assess the role of sildenafil in perioperative management of patients with pulmonary hypertension undergoing lower limb vascular surgery. Patients and methods Twenty-four patients with pulmonary hypertension presented for lower limb vascular surgery were divided into equal groups, group 1 and group 2, each group having 12 patients. Result As regards demographic data, mean arterial pressure, and heart rate there were no statistically significant differences between both groups. As regards PaO₂ measured in arterial blood gases, pulmonary artery pressure, and ejection fraction, there was statistically significant differences between both groups. Conclusion We found that sildenafil has a unique …

Placenta Accreta Index As A Predictor Of Placental Invasion In Cases Of Placenta Previa, Ahmed A. Badr, Ibrahim M. El-Maghraby

Journal of Medicine in Scientific Research

Objective This study aims to evaluate the role of the placenta accreta index in predicting placental invasion in patients with placenta previa. Patients and methods This study was carried on 60 pregnant women with placenta previa (after 30 weeks gestation). They were recruited from the Obstetrics and Gynecology clinic of Menoufia University hospitals and Shebin El Kom Teaching Hospital in the period from January 2019 to December 2020. Results Preterm labor was found in 15 (78.95%) patients in the accreta group and six (14.36%) patients in the nonaccreta group (P = 0.000). Hysterectomy was performed in 14 (73.68%) patients …

Neonatal And Obstetric Risk Factors Are Associated With The Increased Risk Of Neonatal Intracranial Hemorrhage, Manal S. Ramadan, Mennat A. M. El-Barbary, Nada M. Fadel Elsayed

Journal of Medicine in Scientific Research

Background In newborns, intracranial hemorrhage (ICH) is an acquired lesion with a high risk of morbidity, mortality, and long-term neurodevelopmental outcomes. Despite major improvements in newborn care and greater preterm infant survival in recent decades, ICH remains a serious concern. This study aimed to determine the prevalence of ICH in newborns and the various obstetric and neonatal risk factors linked to ICH development. This case–control study was conducted throughout the period from June 2017 to December 2017. Patients and methods This case–control research involved 240 infants admitted to Cairo University's Obstetrics and Gynecology Hospital's Neonatal Intensive Care Unit (NICU). We …

A Retrospective Study Of Children With Multisystemi Nflammatory Syndrome And Intravenous Immunoglobulin Treatment, Balleda Lokeswari, Kolla Sravani, Thimmapuram Chandrasekhara Reddy

Journal of Medicine in Scientific Research

Objectives To compare the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 infection treated with intravenous immunoglobulin (IVIG) and without IVIG. Patients and methods A retrospective observational study was conducted over a period of 2 months. We enrolled all children (1–18 years, both sexes) who presented with coronavirus disease 2019-associated MIS-C (as per WHO definition). The patient classification and treatment were done as per the PGIMER Chandigarh protocol (IVIG along with corticosteroids and aspirin was given in all cases with moderate, severe disease, and Kawasaki disease phenotype). Mild cases did not receive …

Role Of Mri In Evaluation And Characterization Of Neoplastic And Nonneoplastic Cardiac Masses, Ibraheim M. Helmy, Yara M. A. Ziada

Journal of Medicine in Scientific Research

Background The overall frequency of cardiac tumors is quite low, with an estimated cumulative prevalence of 0.002–0.3% at autopsy, however, they represent an important group of cardiovascular abnormalities as the early and accurate diagnosis maybe curative and sometimes avoids unnecessary surgery. Aim and objectives The aim of this study was to evaluate the efficacy of MRI, in diagnosis, evaluation, and characterization of cardiac neoplasms, as identification and differentiation between the cardiac masses are of extreme importance to develop exquisite better therapeutic planning and positive prognostic results. Patients and methods This study is a prospective one that was conducted on 27 …

Immunohistochemical Expression Of Estrogen Receptors, Progesterone Receptors, And Human Epidermal Growth-Factor Receptor 2/Neu In Epithelial Ovarian Tumors, Hanan S. Abdel Hamid, Sherien A. Mohamed, Suzan M. Talaat, Zaineb Y. Mohieldin

Journal of Medicine in Scientific Research

Background and objectives Epithelial ovarian cancer (OC) is a clinically, morphologically, and molecularly heterogeneous disease. Estrogen receptor (ER) β is highly represented in normal ovarian epithelial cells and benign tumors, but ERα is the main form expressed in OC. ERα-positive OC had a favorable outcome. Progesterone receptor (PR) expression in ovarian tumors is a good prognostic marker associated with longer progression-free survival. Human epidermal growth-factor receptor (HER) 2 expression is associated with a worse prognosis. The aim of the study was to evaluate immunohistochemical (IHC) expression of ER, PR, and HER2/neu in ovarian epithelial tumors and to correlate their expression …

Characteristic Clinical Features Of Rheumatic Patients With Covid-19 Infection In Mataria Teaching Hospital, Wael Mahmoud Hossameldin, Wessam Eissa Hamed

Journal of Medicine in Scientific Research

Objective The patients who have rheumatic diseases and have coronavirus disease 2019 (COVID-19) infection, their clinical features have not been reported. This study aims to identify the characteristic clinical features of COVID-19 in patients with rheumatic diseases admitted either inside or outside the ICU and present data to handle these conditions in clinical practice. Patients and methods We conducted a retrospective study, including data about the sex, age, laboratory and radiographic findings, clinical symptoms and signs, ICU admission, and drug history, from 180 patients having COVID-19 infection, and includes 61 patients having in combination of rheumatic diseases, in the period …

Variability Of Clinical Manifestations In Rheumatoid Arthritis Patients With Covid-19 Infection, Soha S. Shaaban, Wessam E. Hamed

Journal of Medicine in Scientific Research

Objective The authors conducted the present retrospective study to assess the epidemiological, clinical, laboratory, and radiological characteristics in coronavirus disease-2019 (COVID-19) associated with rheumatoid arthritis (RA). As known, COVID-19 can cause fatal respiratory infection and may be accompanied with multiorgan affection, including the kidney and heart. The morbidity and mortality may be higher in patients with the immune-deficiency condition. Patients and methods The present study is a retrospective cohort study that retrieved the data of 307 patients with and/or without RA evaluated in Rheumatology Department in Mataria Teaching Hospital, who were previously infected with SARS-CoV-2. Patients' medical record IDs were …

Study Of The Hemodynamic Effect Of Inhaled Milrinone Versus Inhaled Nitroglycerin On Mechanically Ventilated Patients With Pulmonary Hypertension After Mitral Valve Replacement Surgeries, Ahmed K. Abdel Ghany Hassan, Ahmed S. F. Saeed, Paula M. El-Komos Samaan, Sherif S. A. Sultan, Wafaa El-Sayed Ismail Mostafa

Journal of Medicine in Scientific Research

Introduction Pulmonary arterial hypertension (PH) is commonly found in patients with mitral valve diseases. Most of the drugs used for PH treatment are nonselective pulmonary vasodilators that may cause a modest decrease in pulmonary arterial pressure, but they may cause a marked decrease in systemic vascular resistance as well, which leads to hypotension and a decrease in perfusion of vital organs. Inhaled drugs such as milrinone and nitroglycerine may be safer as a large dose of the drug can selectively target the pulmonary circulation, which leads to a reduction of their systemic adverse effects. Aim This double-blind, randomized study compared …

Assessment Of The Clinical Outcomes And Patient Satisfaction When Using Bilateral Radial Artery As Surgical Conduits In Coronary Artery Bypass Grafting, Ashraf Abd-Elaziz, Emmanuel Louka Aziz, Wayel S. Bebawy

Journal of Medicine in Scientific Research

Introduction The need for use of the bilateral radial artery has emerged since we faced patients in our institute with severe uncontrolled diabetes, bilateral leg elephantiasis, and left main disease that needs surgical revascularization. Patients and methods We reviewed the outcomes from our institute with retrospective analysis of prospectively collected clinical data from our local clinical database and identified 30 consecutive patients who underwent coronary artery revascularization requiring the use of bilateral radial harvest. Patient satisfaction was assessed using a quality-of-life questionnaire with the descriptors on a Likert Scale (table A). The patients were followed up both clinically and by …

The Relation Between Coronary Angiographic Findings And Lipoprotein (A) In Patients With Chronic Stable Angina With And Without Xanthelasma, Emmanuel Louka Aziz, Mohamed A. Morsy

Journal of Medicine in Scientific Research

Introduction Atherosclerosis develops in many patients in the absence of classical risk factors. The serum level of lipoprotein [Lp (a)] is of utmost importance in such cases. Many patients with elevated serum level of Lp (a) have xanthelasma with elevated total cholesterol and low-density Lp cholesterol levels. Aim To find the relation between the level of Lp (a) and the severity of coronary artery disease (CAD) in patients with chronic stable angina with and without xanthelasma. Patients and methods The study was carried out on 86 patients in the National Heart Institute. The patients were divided into two groups: group …

Effect Of Pattern-Diode Laser On Central Macular Thickness And Ganglion-Cell Complex After Application In Management Of Clinically Significant Macular Edema, Mohammed S. Ahmed, Rasha G. El-Din Abu-El-Goud

Journal of Medicine in Scientific Research

Background Blindness is the end result of diabetic macular edema (DME). A 577-nm diode laser is the most frequently used one in ophthalmology. This study aimed to assess the effect of grid-diode laser application on the central macular thickness and ganglion-cell complex in management of clinically significant macular edema. Methods This study was performed on 95 eligible eyes. Complete ophthalmologic examination was performed, including best-corrected visual acuity with the use of ETDRS charts, measuring intraocular pressure, using slit lamp for biomicroscopic examination, fluorescein angiography, and fundus examination. Follow-up examinations, with complete ophthalmologic examination, were scheduled at 1 and 3 months …

Coronavirus Disease 2019 And Diabetes Mellitus, Ashraf M. A. Eid, Ehab K. El Melegy, El-Saied A. Shahin, Khaled S. A. Elkelany, Mariam A. Fouad

Journal of Medicine in Scientific Research

Introduction In late 2019, a new virus severe acute respiratory syndrome coronavirus-2, which causes a new serious disease called coronavirus disease 2019 (COVID-19), spread quickly all over the world. Many complications of diabetes mellitus (DM) such as microvascular and macrovascular complications increase the risk for COVID-19-related severity and mortality. Objective To assess the effect of DM on outcome and severity of COVID-19. Patients and methods This work was a retrospective observation that included confirmed COVID-19-infected patients (PCR positive for COVID-19) who were admitted to Shebin El-Kom Teaching Hospital, Menoufia, Egypt, from March 2021 to March 2022. Laboratory investigations such as …

Esophageal Ulcer After Band Ligation Of Esophageal Varices, Ashraf M. A. Eid, El-Saied A. Shahin, Feisal Goda, Mariam A. Fouad

Journal of Medicine in Scientific Research

Introduction Band ligation plays an important role in the management of esophageal varices (EV), but banding ligation carries a risk of band slippage, postbanding esophageal ulcer formation, and postbanding bleeding. Aim The predisposing factors and frequency of esophageal ulcer after banding ligation of EV were assessed. Patients and methods A total of 130 cirrhotic patients with EV were subjected to therapeutic or prophylactic banding ligation, and then the patients were observed for 14 days for detection of incidence of esophageal ulcer bleeding after postbanding ligation. This was a prospective study done to compare the cirrhotic patients without endoscopic variceal ligation …

Effect Of Nesfatin-1 On The Nutritional Status Of Hemodialysis Patients, Ahmed H. M. Elthakaby, Hany Y. Esso, Huda M. Elsayed, Karima Youssef Ahmed, Nagwa Abd El-Ghaffar Mohamed, Ragaa R. Mohamed

Journal of Medicine in Scientific Research

Background Nesfatin-1 is considered an anorexigenic peptide that plays an important role in appetite regulation, weight loss, and malnutrition. Although the cause of anorexia in CKD patients is not totally understood, both anorexia and malnutrition are common presentations of chronic kidney disease (CKD) patients who are susceptible to worse outcomes. Our aim of the work To study the relation of serum nesfatin-1 and its relation to the nutritional status of end-stage renal disease (ESRD), who are maintained on regular hemodialysis. Patients and methods A total of 60 ESRD patients are maintained on regular hemodialysis, and apparently healthy thirty persons (control …

Detection Of Artificial Colors Added To Cooked Faba Beans (Ful Medames) And Microbial Examination For Samples Obtained From Street Vendors In Egypt, El-Sayed M. Hammad, Fardous Soliman, Hanaa Salah, Manal Mohammed, Mohamed Farag, Om H. Ahemad

Journal of Medicine in Scientific Research

Background Cooked dried beans are commonly consumed in many countries and are known in Egypt as Ful medames. Adding synthetic colors to keep the dishes more attractive may have toxic effects on the human body, as it may be unsafe to consume potentially microbial contaminated foods, especially when obtained from street vendors. Aim The aim of this study was to detect the types of artificial colors added to cooked faba bean (Ful medames) by street vendors in Egypt and highlight their health hazards and microbial hazards. Materials and methods A total of 100 convincing samples were collected from street vendors …

Evaluating Antioxidant And Antimicrobial Activities Of Essential Oils Extracted From Six Plants: Caraway, Mint, Onion, Parsley, Fennel, And Watercress, Amro A.E M. El Sayed, Mohamed F. Mohammady, Osama A. A. Rashwan

Journal of Medicine in Scientific Research

Background Essential oils extracted from mint, parsley, caraway, onion, fennel, and watercress contain compounds that have different effects on the growth of some microbial strains. These volatile oils can also be used to flavor some foods and preserve foods to extend their shelf life. Aim To identify the composition of extracted volatile oils and know their effect on the growth of some microbial strains. Materials and methods Commercial samples of six plants (caraway, mint, onion, parsley, fennel, and watercress) were purchased from the local market. Extractions of essential oils from the sample as well as gas chromatography/mass spectrometry analysis were …

Protective Effects Of Antioxidant Vitamins (C Plus E) Against Oxidative Damage Induced By The Insecticide Imidacloprid In Male Rats, Afaf A. Shalaby, Marwa E. Hassan, Mohamed B. Shalaby

Journal of Medicine in Scientific Research

Introduction Imidacloprid (IMC) is a synthetic neonicotinoid insecticide that is used in agriculture against harmful insects. Aim This study aimed to investigate the adverse effects of the IMC formulation on biochemical, hematological parameters, oxidative stress markers, pro-inflammatory cytokines, alpha-fetoprotein (AFP), and testosterone levels in male rats, and to determine the potential protective activity of vitamin C and E against IMC insecticides in rats. Material and methods The rats were divided into four groups. The first group was used as a control. The second, third, and fourth groups received vitamin C (200 mg/kg) plus vitamin E (200 mg/kg), IMC (45 mg/kg), …