Medical Specialties Commons^™

Tuning The Thermodynamic, Optical, And Rheological Properties Of Thermoresponsive Polymer Solutions Via Silica Nanoparticle Shape And Concentration, Christopher A P Neal, Valeria León, Michelle C Quan, Nondumiso O Chibambo, Michelle A Calabrese

Faculty, Staff and Student Publications

HYPOTHESIS: The shape and quantity of hydrophilic silica nanoparticles (NPs) can be used to tune the microstructure, rheology, and stability of phase-separating polymer solutions. In thermoresponsive polymer systems, silica nanospheres are well-studied whereas anisotropic NPs have little literature precedent. Here, we hypothesize that NP shape and concentration lower the onset of rheological and turbidimetric transitions of aqueous poly(N-isopropyl acrylamide) (PNIPAM) solutions.

EXPERIMENTS: Differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), turbidimetry, and oscillatory rheology are utilized to examine interactions between NPs, PNIPAM, and water and to track changes in phase separation and rheological properties due to NP concentration and shape. …

Next-Generation Ctla-4 Targeting Molecules And Combination Therapy: Promising Strategies For Improving Cancer Immunotherapy, Nils-Petter Rudqvist, Manushak Avagyan, Dhan Chand

Faculty, Staff and Student Publications

Radiation therapy and anti-CTLA-4 combination therapy can induce meaningful responses in some patients. Adding CD40 may provide additional benefit. Next-generation anti-CTLA-4 antibodies, such as botensilimab, are showing promise in clinical trials. Combining botensilimab with RT and/or CD40 agonist may offer additional benefits for challenging tumor types.

Stereotactic Body Proton Therapy For Early Stage Non-Small Cell Lung Cancer – Technical Challenges And Solutions: The Md Anderson Experience, X Ronald Zhu, Yuting Li, Ming Yang, Thomas J Whitaker, Paige A Taylor, Xiaodong Zhang, Falk Poenisch, Narayan Sahoo, Zhongxing Liao, Joe Y Chang

Faculty, Staff and Student Publications

Our randomized clinical study comparing stereotactic body radiotherapy (SBRT) and stereotactic body proton therapy (SBPT) for early stage non-small cell lung cancer (NSCLC) was closed prematurely owing to poor enrollment, largely because of lack of volumetric imaging and difficulty in obtaining insurance coverage for the SBPT group. In this article, we describe technology improvements in our new proton therapy center, particularly in image guidance with cone beam CT (CBCT) and CT on rail (CTOR), as well as motion management with real-time gated proton therapy (RGPT) and optical surface imaging. In addition, we have a treatment planning system that provides better …

A Randomized Double-Blind Prospective Study Comparing The Efficacy Of Subperiosteal And Periarticular Injections Of A Local Anesthetic For Postoperative Pain Management After Total Knee Arthroplasty, Reza Minaei, Mohammad Salehpour, Emad Kouhestani, Mahshid Ghasemi

Faculty, Staff and Student Publications

OBJECTIVES: Total knee arthroplasty (TKA) serves as an effective surgical treatment method for advanced osteoarthritis (OA). Nonetheless, it is associated with postoperative pain that can influence patients' functional outcome. This study aimed to compare the analgesic effect of subperiosteal and periarticular injection methods of a special local anesthetic in patients who underwent TKA.

METHODS: This double-blind prospective clinical study was conducted on patients with advanced knee OA who underwent TKA. Patients were randomly divided into two groups, with a local anesthetic (21 ml) administered either in periarticular (P group) or subperiosteal (S group) forms prior to wound closure. The local …

Multi-Faceted Role Of Lrp1 In The Immune System, Olga Sizova, Lisa St John, Qing Ma, Jeffrey J Molldrem

Faculty, Staff and Student Publications

Graft versus host disease (GVHD) represents the major complication after allogeneic hematopoietic stem cell transplantation (Allo-SCT). GVHD-prone patients rely on GVHD prophylaxis (e.g. methotrexate) and generalized anti-GVHD medical regimen (glucocorticoids). New anti-GVHD therapy strategies are being constantly explored, however there is an urgent need to improve current treatment, since GVHD-related mortality reaches 22% within 5 years in patients with chronic GVHD. This review is an attempt to describe a very well-known receptor in lipoprotein studies - the low-density lipoprotein receptor related protein 1 (LRP1) - in a new light, as a potential therapeutic target for GVHD prevention and treatment. Our …

Colorectal Surveillance Outcomes From An Institutional Longitudinal Cohort Of Lynch Syndrome Carriers, Gabriel Del Carmen, Laura Reyes-Uribe, Daniel Goyco, Kyera Evans, Charles M Bowen, Jennifer L Kinnison, Valerie O Sepeda, Diane M Weber, Julie Moskowitz, Maureen E Mork, Selvi Thirumurthi, Patrick M Lynch, Miguel A Rodriguez-Bigas, Melissa W Taggart, Y Nancy You, Eduardo Vilar

Faculty, Staff and Student Publications

OBJECTIVE: Lynch Syndrome (LS) carriers have a significantly increased risk of developing colorectal cancer (CRC) during their lifetimes. Further stratification of this patient population may help in identifying additional risk factors that predispose to colorectal carcinogenesis. In most LS patients CRC may arise from adenomas, although an alternative non-polypoid carcinogenesis pathway has been proposed for

DESIGN: We collected demographics, genetic, colonoscopy, and pathology results from a total of 163 LS carriers who obtained regular screening care at MD Anderson Cancer Center. Data were extracted from the electronic health records into a REDCap database for analysis. Logistic regressions were performed to …

Exercise And Ischemia-Activated Pathways In Limb Muscle Angiogenesis And Vascular Regeneration, Vihang A Narkar

Faculty, Staff and Student Publications

Exercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular condition that benefits from regular exercise or rehabilitative physical therapy in terms of slowing the progression of disease and delaying amputations. Various rodent pre-clinical studies using models of PAD and exercise have shed light on molecular pathways of vascular regeneration. Here, I review key exercise-activated signaling pathways (nuclear receptors, kinases, and hypoxia inducible factors) in the skeletal muscle that drive paracrine regenerative angiogenesis. The rationale for highlighting the skeletal muscle is that it is the largest organ recruited …

Fanconi Anemia Caused By Biallelic Inactivation Of Brca2 Can Present With An Atypical Cancer Phenotype In Adulthood, Kara N Maxwell, Vishal Patel, Kevin T Nead, Shana Merrill, Dana Clark, Qinqin Jiang, Bradley Wubbenhorst, Kurt D'Andrea, Roger B Cohen, Susan M Domchek, Jennifer J D Morrissette, Roger A Greenberg, Daria V Babushok, Katherine L Nathanson

Faculty, Staff and Student Publications

Inherited biallelic pathogenic variants (PVs) in BRCA2 cause Fanconi Anemia complementation group D1 (FA-D1), a severe pediatric bone marrow failure and high-risk cancer syndrome. We identified biallelic BRCA2 PVs in a young adult with multiple basal cell carcinomas, adult-onset colorectal cancer and small cell neuroendocrine carcinoma, without bone marrow failure. No PVs were identified in any other known cancer susceptibility gene, and there was no evidence of reversion mosaicism. The proband's deceased sister had a classic FA-D1 presentation and was shown to carry the same biallelic BRCA2 PVs. A lymphoblastoid cell line derived from the proband demonstrated hypersensitivity to DNA …

Glyceryl Trinitrate Cream Versus Lateral Sphincterotomy In Management Of Chronic Anal Fissure: A Prospective Randomized Comparative Study, Naser T. Elshamy

Journal of Medicine in Scientific Research

Objective The aim is to compare complications and long-term outcome of two treatment modalities of chronic anal fissure: chemical sphincterotomy by glyceryl trinitrate (GTN) cream and lateral internal sphincterotomy. Background Treatment of chronic anal fissure is achieved by the reduction in the tone of the internal anal sphincter either chemically or surgically. Patients and methods In the period from November 2013 to October 2015, all patients who were admitted to the Department of General Surgery in Shebin Elkom Teaching Hospital complaining of chronic anal fissure were included in the study. According to inclusion and exclusion criteria, patients were selected and …

An Observational Study Of The Association Of Preoperative Mri Findings And Intraoperative Findings In Patients With Fistula In Ano, Tushar Sharmaa, Nabal K. Mishra, Shyam Lal, Tanweer Karim, Rahul Rohitaj, Gaurav Patel

Journal of Medicine in Scientific Research

Objective To assess the precision of preoperative MRI pelvis for identification of anal fistulas with regard to intraoperative findings. Patients and methods A prospective observational cohort study was done in the Department of General Surgery, over a period of 18 months (October 2019–April 2021) during which all diagnosed cases of fistula in ano admitted for elective surgery were included and operated by an experienced surgeon. MRI and clinical evaluation were done preoperatively and correlated with intraoperative findings. Patients were followed up for 12 weeks during which recurrence and complications were noted. Results The mean age of the patients was 36.98 …

Ocular Vestibular Evoked Myogenic Potentials In Patients With Single Sided Deafness, Alshymaa Ibrahim Hammad, Sanaa Mahran

Journal of Medicine in Scientific Research

Introduction: Clinically unilateral severe to profound sensorineural hearing loss known as single-sided deafness (SSD). It is defined by severe-to-profound hearing thresholds with a poor word recognition ability. SSD is not uncommonly encountered in otology, their symptoms is hearing loss and often associated with the vestibular system. In SSD otolithic dysfunction may be frequently misdiagnosed and majority of patients affected by cochlear and superior vestibular nerve then inferior vestibular nerve. Otolith damage may be present in patients with SSD because they sharing a membranous structure in addition they have similar receptor cell. The vestibule and cochlea may be impacted by the …

Assessment Of The Right Ventricular Function Before And After Coronary Artery Bypass Surgery By Conventional And Tissue Doppler Echocardiography, Emmanuel L. Aziz, Mohamed Abbas, Ashraf Abd-Elaziz, Wayel S. Bebawy

Journal of Medicine in Scientific Research

Aim of the work To study the extent of right ventricular (RV) dysfunction in ischemic patients after coronary artery bypass grafting (CABG). Patients and methods RV function was studied preoperatively and followed for 1 month postoperatively in 40 patients who were scheduled for elective coronary artery bypass surgery and in other 40 controls. We evaluated RV function by tissue Doppler study of the tricuspid annulus and the basal septum, tricuspid annular plane systolic excursion, and RV dimensions. Both LV dimensions, left atrium dimensions, and aortic root dimensions were also measured before and after surgery. Results RV function was significantly reduced …

Mortality Rate Among Preterm Infants With Respiratory Distress Syndrome On Non-Invasive Respiratory Support (Nirs): A ٌRetrospective Multicenter Study, Abeer E.S. Hamed, Alaa A. Rashad, Manar A. El Desouky, Mahmoud H. Dawabah, Mohamed M. A. Shaheen, Heba Allah M. Sherief, Mohamed A. Ibrahim, Sohaila A Abd El-Halim

Journal of Medicine in Scientific Research

Background: Neonatal acute respiratory distress is a common cause for mortality and morbidity in preterm neonates. Non-invasive ventilation is crucial for preterm neonates, nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure. Recently, heated humidified high-flow nasal cannula modes have been revealed as more efficient non-invasive ventilation mode in improving functional residual capacity however, other studies have questioned its efficacy and safety in comparison to other non-invasive ventilation. Many studies have investigated the common predictive factors that are associated with intubation and failure of spontaneous breathing. Consequently, this study aimed at investigating the common factors associated with prolonged …

Role Of High-Resolution Ultrasonography And Electromyography In The Evaluation Of Patients With Flat Foot, Mai M. Kamel, Ahmed Abdelrahman Elatreby, Amr M. Gamil, Gamal Salah Eldin Elmorsy

Journal of Medicine in Scientific Research

Objective: The present work aimed to assess the abductor hallucis (AH) muscle changes using sonographic and electrophysiologic studies in flatfoot patients. Patients and methods: This study included 60 patients with flatfoot deformity (group I) and 20 age and sex-matched healthy individuals as a control group (group II). The patients were subjected to full history taking, clinical assessment, foot x-ray examination, high-resolution ultrasound, and surface electromyography (EMG) of AH muscle. Using a plain x-ray, Meary's angle was measured, and severity grading was categorized for the patient group. Results: The AH ultrasonography revealed a significant difference between patient and control groups regarding …

Crossed Testicular Ectopia (Cte), A Rare Anomaly: Case Report And Review Of The Literature, Mohammed Rabea Balaswad, Wael Ghorab, Shrief Mebed

Journal of Medicine in Scientific Research

BACKGROUND: A relatively uncommon urogenital anomaly known as crossed testicular ectopia (CTE) can be defined by the emigration of one testis into the opposing inguinal canal, which could possibly be ectopic in the abdominal cavity, inguinal region, or even descend to the opposing hemi-scrotum. Following a review of the literature, the most common classification is to subdivide CTE into three categories based on associations: I, which tends to be associated with inguinal hernia alone; II, which is predominantly associated with persistent mullerian remnants; and III, which is most frequently associated with other anomalies without mullerian remnants. CASE PRESENTATION: We describe …

Assessment Of Outcome Of Cochlear Implant In Auditory Neuropathy Spectrum Disorder Using Speech In Noise Test, Ahmed Mostafa, Sameh Nazmi Siam, Azza Abdel Aziz Azzam, Hanaa Fadel

Journal of Medicine in Scientific Research

Introduction: Children with auditory neuropathy spectrum disorder (ANSD) generally struggle with auditory and language treatment, and cochlear implants' (CIs') outcomes can be unpredictable. environmental noise. The speech discrimination ability is the main complaint of those patients especially in background Objective: Assessment of the ability of young children diagnosed with ANSD who underwent CI in one ear to discriminate speech by using "speech in noise test" with 0 Signal to noise ratio (S/N) and comparing them with matched children with severe to profound sensori-neural hearing loss (SNHL). Methods: The study was conducted on 27 children who received "unilateral" CI of different …

Outcome Of Different Treatment Methods In Patients With Tinnitus And Temporomandibular Joint Dysfunction, Sanaa Mahran Mohamed Andeil, Anwar Moawad Elbatawy, Zienab Shalaby Farid Shalaby

Journal of Medicine in Scientific Research

Introduction: Otology symptoms can be the presenting complain among patients with temporomandibular joint (TMJ) dysfunction. The ear symptoms related to Temporomandibular joint dysfunction are hearing loss and tinnitus. Tinnitus related to TMJ dysfunction is referred to as a type of somatic tinnitus, and it is caused by a musculoskeletal problem, which should be investigated with different methods of treatment to increase the best efficiency of treatment. Objective: Evaluation of different outcomes of different treatment modalities for patients with tinnitus and TMJ dysfunction by using the advantage of Tinnitus Retraining Therapy versus night guard and medication to determine which of these …

Effect Of Empagliflozin Metformin With Clomiphene Citrate Versus Metformin With Clomiphene Citrate On Cases Of Polycystic Ovary Syndrome, Diaa Shams Eldin El Gohary, Mohammed Mohammed Ismail, Ahmed Mahmoud El Khayat, Sherin Barakat Elbohoty

Journal of Medicine in Scientific Research

Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age associated with long-term metabolic and cardiovascular consequences. Aim and objectives: In this research, we aimed to assess the impact of Empagliflozin Metformin with Clomiphene Citrate versus Metformin with Clomiphene Citrate on weight reduction and its impact on folliculometry and ovarian volume in cases of Polycyctic Ovary Syndrome. Subjects and Methods: This was a randomized clinical trial; in which 150 Patients were being randomly assigned into two equal groups; Group A: 75 cases received empagliflozin metformin 12.5/500 mg Continously once daily plus clomiphene citrate 50 mg …

Community-Acquired Pneumonia Among Hospitalized Children: Risk Factors, Characteristics, And Outcomes, Marwa Taha, Hanaa Abdel-Wahab

Journal of Medicine in Scientific Research

Background Community-acquired pneumonia (CAP) represents one of the main causes of mortality and morbidity among under-five children worldwide. More than 75% of these fatalities are caused by severe pneumonia. Objectives to identify the potential risk factors associated with severe CAP among under-five children hospitalized with CAP. Patients and Methods This prospective observational study was conducted on children, aged 1 to 59 months, who were admitted with CAP to the Department of Pediatrics, Mataria Teaching Hospital, Egypt. Based on World Health Organization (WHO) guidelines, patients were classified into two groups; CAP and severe CAP. Data including demographic, children's history, clinical assessment, …

A Rare Case Of Fahr’S Disease, Kesar Prajapati, Vishakha Vinod, Sumit Bochiwal

Journal of Medicine in Scientific Research

Fahr’s syndrome, a rare syndrome, is characterized by symmetrical and bilateral intracranial calcifications. A 23-year-old male patient presented with generalized tonic–clonic convulsion and muscle cramps for 1 month. The patient’s blood counts, blood sugar levels, serum sodium, and serum potassium were normal. Computed tomography scan of the brain revealed bilateral symmetrical hyperdensities, suggestive of calcification in globus pallidus, putamen, thalami, caudate and dentate nuclei of the cerebellum, and subcortical white matter of both cerebral hemispheres. The findings were suggestive of Fahr’s disease. His serum ionized calcium levels were low with high phosphate levels (with increased parathormone levels), suggesting the association …

Saphenous Vein Harvesting With Endoscopy Versus No-Touch Technique: Short-Term Results, Tamer El Bannaa, Mohamed M. Mohamed, Ahmed Zayed, Yasser A. Sadek

Journal of Medicine in Scientific Research

Objective ‘No-touch’ (NT) saphenous vein harvesting maintains vasa vasorum, resulting in less medial ischemic affection, which leads to improved short-term and long-term patency. However, it may also be associated with a higher rate of wound complications. Endovascular vein harvesting (EVH) has a low rate of wound complications but also a tendency toward a lower patency rate. The aim was to compare wound complications and short-term symptomatic relief, which could be an indication of functioning grafts. Patients and methods During a 2-year period (2018–2019), in a nonrandomized prospective study, we monitored patients after coronary artery bypass graft for recurrence of ischemic …

Voice Quality Assessment In Cases Of Vocal Fold Gaps After Single Growth Factor Injection, Amr Roushdyel Badrawy, Asmaa Abdel Hamid, Israa Eltaweel, Azza Abdel Aziz Azzam

Journal of Medicine in Scientific Research

In severe vocal fold (VF) lesions, deposits of disorganized, thick collagen bundles and little hyaluronic acid (HA) are deposited in the superficial layer of lamina propria (SLP). These changes lead to severe dysphonia and aspiration, which could be complicated by fatal pneumonia. Unfortunately, no specific treatment has been recognized due to unpredictable VF regeneration. Current progress in regenerative medicine has allowed the development of tissue engineering techniques using cells, scaffolds, and growth factors (GFs). Extrinsic GFs application could help in the induction of the regenerative process. The work aims to assess the voice quality after a single GF injection of …

Protein S In Coagulation And Inflammation, Martha Mega Silvia Sim

Theses and Dissertations--Molecular and Cellular Biochemistry

Protein S (PS) is a key regulator, which links inflammation and coagulation and performs multiple proposed functions in both processes. PS exists in the blood as a free soluble form (~40%), bound to complement component 4b-binding protein/ C4BP (~60%), and packaged in platelet α-granules (~2.5%). Subendothelial tissue factor (TF), upon exposure to blood, initiates coagulation, a proteolytic cascade which results in the activation of thrombin, the enzyme responsible for formation of a fibrin clot. PS is a critical anticoagulant that inhibits multiple steps of this process. Only the free fraction of PS has full anticoagulant properties, as C4BP blocks this …

The Link Between Intracellular Calcium Signaling And Exosomal Pd-L1 In Cancer Progression And Immunotherapy, Rakibul Alam, Mizanur Rahman, Zhiguo Li

Markey Cancer Center Faculty Publications

Exosomes are small membrane vesicles containing microRNA, RNA, DNA fragments, and proteins that are transferred from donor cells to recipient cells. Tumor cells release exo- somes to reprogram the factors associated with the tumor microenvironment (TME) causing tu- mor metastasis and immune escape. Emerging evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1 (PD-L1) that binds with re- ceptor program death protein 1 (PD-1) and promote tumor progression by escaping immune response. Currently, some FDA-approved monoclonal antibodies are clinically used for cancer treatment by blocking PD-1/PD-L1 interaction. Despite notable treatment outcomes, some pa- tients show …

N-Of-1 Trials: The Epitome Of Personalized Medicine?, Joyce P Samuel, Susan H Wootton, Jon E Tyson

Faculty, Staff and Student Publications

Observational studies are notoriously susceptible to bias, and parallel-group randomized trials are important to identify the best overall treatment for eligible patients. Yet, such trials can be expected to be a misleading indicator of the best treatment for some subgroups or individual patients. In selected circumstances, patients can be treated in n-of-1 trials to address the inherent heterogeneity of treatment response in clinical populations. Such trials help to accomplish the ultimate goal of all biomedical research, to optimize the care of individual patients.

Early-Phase Drive To The Precursor Pool: Chloroviruses Dive Into The Deep End Of Nucleotide Metabolism, David Dunigan, Irina Agarkova, Ahmed Esmael, Sophie Alvarez, James L. Van Etten

Nebraska Center for Virology: Faculty Publications

Viruses face many challenges on their road to successful replication, and they meet those challenges by reprogramming the intracellular environment. Two major issues challenging Paramecium bursaria chlorella virus 1 (PBCV-1, genus Chlorovirus, family Phycodnaviridae) at the level of DNA replication are (i) the host cell has a DNA G+C content of 66%, while the virus is 40%; and (ii) the initial quantity of DNA in the haploid host cell is approximately 50 fg, yet the virus will make approximately 350 fg of DNA within hours of infection to produce approximately 1000 virions per cell. Thus, the quality and quantity of …

The Persistence And Stabilization Of Auxiliary Genes In The Human Skin Virome, Ema H. Graham, Wesley A. Tom, Alison C. Neujahr, Michael Adamowicz, Jennifer Clarke, Joshua R. Herr, Samodha C. Fernando

Nebraska Center for Virology: Faculty Publications

Background The human skin contains a diverse microbiome that provides protective functions against environmental pathogens. Studies have demonstrated that bacteriophages modulate bacterial community composition and facilitate the transfer of host-specific genes, potentially influencing host cellular functions. However, little is known about the human skin virome and its role in human health. Especially, how viral-host relationships influence skin microbiome structure and function is poorly understood.

Results Population dynamics and genetic diversity of bacteriophage communities in viral metagenomic data collected from three anatomical skin locations from 60 subjects at five different time points revealed that cutaneous bacteriophage populations are mainly composed of …

Erratum

Saudi Medical Journal

No abstract provided.

How Do Glp-Ira Medications Affect Gut And Brain Hunger Signaling To Allow For Reduction In Weight And Better Glycemic Control In Adults With Obesity And Type 2 Diabetes?, David White

Graduate Research Projects

No abstract provided.

The Effect Of An Educational Handout On Knowledge, Awareness And Attitudes Of Pre-Exposure Prophylaxis (Prep) Among Participants At A Needle And Syringe Exchange Site, Mckenzie Buckel

DNP Projects

Background: In 2018, the total number of HIV cases in the United States was 1.2 million. Almost 186,500 of these cases were attributed to intravenous drug use. With the adherence to pre-exposure prophylaxis (PrEP) there is approximately a 49% decrease in the rates of HIV among people who inject drugs and the most significant barrier to PrEP among this population is a lack of awareness and knowledge.

Objective: The purpose of this study was to determine participants’ of a needle and syringe exchange site knowledge, awareness and attitudes of PrEP after reviewing an educational handout about PrEP.

Methods: A quasi …