Medical Specialties Commons^™

Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel

Dissertations, Theses, and Capstone Projects

Nucleosome core particles (NCP) are the building blocks that form a highly organized and compact chromatin structure. Nucleosomes package DNA in the nucleus of eukaryotic cells. The NCP consists of about 147 base pairs of DNA wrapped around the histone octamer, with 1.65 superhelical turns in a left-handed manner. The histone octamer is composed of two copies of H3, H4, H2A, and H2B. Together with histone H1 and linker DNA, they further assemble into a higher-order chromatin structure. The nucleosome complex is stabilized by electrostatic interactions between positively charged histone residues and the negatively charged DNA backbone. To effectively access …

Routine Transfusion Of Rh(D)-Positive Rbcs To Rh(D)-Negative Patients Designated As Do Not Resuscitate Conserves Rh(D)-Negative Red Blood Cell Inventory, Julie Katz Karp, Jovanna Everetts, Juliana Guarente, Angelica Vivero, Tiffany Bohr, Mary Harach

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: A minority of blood donors are Rh(D)-negative, and Rh(D)-negative red blood cell (RBC) products are often overutilized. As such, Rh(D)-negative RBCs may be difficult to maintain in blood bank inventory.

Study design and methods: We changed our blood bank laboratory policy to approve non-alloimmunized Rh(D)-negative patients to receive Rh(D)-positive RBCs for routine transfusion under defined criteria. Those criteria included Rh(D)-negative males (all ages) and females (aged >50 years) who were designated as do not resuscitate (DNR), either with or without intubation, in the electronic medical record.

Results: From August 15, 2024 through August 15, 2025, a total of 204 …

Exploring Csf Microrna Signatures As Diagnostic Biomarkers In Adult-Type Diffuse Gliomas, Maryam Pirhoushiaran, Kamilah Walker-Charles, Tsung-Hung Yao, Satwikreddy Putluri, Nehal Patel, Daniel H Wang, Isabel Wang, Srividya Arjuna, Antonio Dono, Angel Bueno, Sophia Nguyen, Ashish P Balar, Jason T Huse, Suprateek Kundu, Yoshua Esquenazi, Chirag B Patel, Sujit S Prabhu, Frederick F Lang, Leomar Y Ballester

Faculty, Staff and Student Publications

Mutations in isocitrate dehydrogenase (IDH) genes, specifically IDH1 and IDH2, are frequently observed in diffuse gliomas (DG) and define distinct molecular subtypes, namely IDH-wildtype and IDH-mutant. Abnormal expression of extracellular vesicle-derived microRNAs (EV-miRNAs) in the cerebrospinal fluid (CSF) of DG patients may serve as minimally invasive diagnostic and prognostic biomarkers. To investigate this potential, we employed miRNA-sequencing (miRNA-seq), quantitative real-time PCR (qRT-PCR), and multivariable logistic regression (MLR) to identify differentially expressed microRNAs (DE-miRNAs) in CSF samples from DG patients. qRT-PCR analysis demonstrated that EV-miR-21-5p effectively differentiated CSF from glioblastoma (GBM) patients versus controls (p = 0.012, AUC = 0.84) and …

Nlrp3 Inflammasome: A Link Between Systemic Infection And Alzheimer’S Disease, Tatiana Barichello, Felipe Dal-Pizzol

Faculty, Staff and Student Publications

No abstract provided.

Exploring Csf Microrna Signatures As Diagnostic Biomarkers In Adult-Type Diffuse Gliomas, Maryam Pirhoushiaran, Kamilah Walker-Charles, Tsung-Hung Yao, Satwikreddy Putluri, Nehal Patel, Daniel H Wang, Isabel Wang, Srividya Arjuna, Antonio Dono, Angel Bueno, Sophia Nguyen, Ashish P Balar, Jason T Huse, Suprateek Kundu, Yoshua Esquenazi, Chirag B Patel, Sujit S Prabhu, Frederick F Lang, Leomar Y Ballester

Faculty, Staff and Student Publications

Mutations in isocitrate dehydrogenase (IDH) genes, specifically IDH1 and IDH2, are frequently observed in diffuse gliomas (DG) and define distinct molecular subtypes, namely IDH-wildtype and IDH-mutant. Abnormal expression of extracellular vesicle-derived microRNAs (EV-miRNAs) in the cerebrospinal fluid (CSF) of DG patients may serve as minimally invasive diagnostic and prognostic biomarkers. To investigate this potential, we employed miRNA-sequencing (miRNA-seq), quantitative real-time PCR (qRT-PCR), and multivariable logistic regression (MLR) to identify differentially expressed microRNAs (DE-miRNAs) in CSF samples from DG patients. qRT-PCR analysis demonstrated that EV-miR-21-5p effectively differentiated CSF from glioblastoma (GBM) patients versus controls (p = 0.012, AUC = 0.84) and …

Ldm-Morph: Latent Diffusion Model Guided Deformable Image Registration, Jiong Wu, Tinsu Pan, Kuang Gong

Faculty, Staff and Student Publications

Deformable image registration plays an essential role in various medical image tasks. Existing deep learning-based deformable registration frameworks primarily utilize convolutional neural networks (CNNs) or Transformers to learn features to predict the deformations. However, the lack of semantic information in the learned features limits the registration performance. Furthermore, the similarity metric of the loss function is often evaluated only in the pixel space, which ignores the matching of high-level anatomical features and can lead to deformation folding. To address these issues, in this work, we proposed LDM-Morph, an unsupervised deformable registration algorithm for medical image registration. LDM-Morph integrated features extracted …

Transcranial Ac Modulation Of Cerebellar Nuclear Activity In Awake Animals, Nuran Kavakli

Dissertations

Entrainment of cerebellar nuclear (CN) cells via cerebellar transcranial alternating current stimulation (ctACS) has been reported in animals under ketamine/xylazine anesthesia. Our main objective was to demonstrate modulation of CN activity in unanesthetized, freely moving animals using ctACS. Multi-channel carbon-fiber electrodes were implanted into the interpositus nucleus for recording multi-unit (MU) activity, and thin-film electrodes were implanted subcutaneously over the posterior cerebellum for stimulation. A frequency-domain-based metric was developed to quantify modulation from MU signals. The results demonstrated modulation in a wide range of frequencies (4 Hz-300 Hz) as in anesthetized animals. In contrast, the amplitude of the peak in …

Fda Approval Of Tradipitant: A Novel Approach To Motion Sickness Treatment, Haley Brown, Jennifer Cao, Allie Honigford, Leah Heitkamp, Sarah Hiett, Connor Dains, Brenna Hissong, Manoranjan D'Souza

Pharmacy and Wellness Review

Motion sickness is a prevalent neurophysiological condition affecting approximately one-third of the worldwide population, resulting from sensory mismatch and the brain’s internal model of motion. It is characterized by nausea, vomiting, dizziness, and autonomic symptoms during exposure to actual or virtual motion, which may significantly impair daily functioning and quality of life. Current guidelines recommend the prevention and treatment of motion sickness through pharmacologic, herbal, and non-pharmacologic strategies. Scopolamine and first-generation antihistamines are effective pharmacologic options, while ginger has demonstrated some benefit in reducing symptoms as an herbal option. Non-pharmacologic interventions such as habituation training, behavioral techniques, and sensory strategies …

Evaluating The Market Withdrawal Of Andexanet Alfa, Jordyn Linfield, Addisyn Cooper, Alexander Defranco, Emma Gerding, Jessica Kelley, Tyler Henney, Connor Dains, Brenna Hissong, Brittany Bates

Pharmacy and Wellness Review

The coagulation cascade comprises intrinsic, extrinsic, and common pathways that converge when thrombin converts fibrinogen (factor I) into fibrin, leading to fibrin mesh formation, stabilization of the platelet plug, and ultimately thrombus formation. Inhibition of the coagulation cascade can be achieved with a variety of anticoagulant medications, including direct oral anticoagulants (DOACs). The mechanism of action of DOACs is to inhibit either factor Xa or thrombin. Reversal of anticoagulation remains an important clinical consideration when managing patients on DOACs who experience serious bleeding events. Andexanet alfa is a recombinant, modified human factor Xa protein previously indicated for patients receiving rivaroxaban …

Fda Approval Of Etripamil For The Treatment Of Paroxysmal Supraventricular Tachycardia, Kiley Devoll, Daniella Egbujor, Katy Grainger, Katherine Cook, Victoria Niese, Connor Dains, Brenna Hissong, Andrew Roecker

Pharmacy and Wellness Review

Paroxysmal supraventricular tachycardia (PSVT) is characterized by sudden, brief, intermittent episodes that result in a heart rate of 150 to 250 beats per minute (bpm). PSVT is difficult to diagnose, making proper treatment challenging. According to the 2015 American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Rhythm Society (HRS) guidelines, current pharmacologic recommendations for PSVT include adenosine, verapamil, diltiazem, or nonpharmacologic vagal maneuvers.¹ These treatments each have a variety of adverse effects, contraindications, and dosing considerations, which highlight a need for novel therapies for the acute treatment and maintenance of PSVT.¹ The NODE-301 trial assessed the safety and …

A Disorder-Aware Computational Framework To Identify Structurally Tractable Targets In Proliferative Vitreoretinopathy, Mak B. Djulbegovic, Nedym Hadzijahic, David J. Taylor Gonzalez, Michael Antonietti, Sidra Zafar, Ajay E. Kuriyan

Wills Eye Hospital Papers

OBJECTIVE: Proliferative vitreoretinopathy (PVR) remains a major cause of failure after rhegmatogenous retinal detachment repair and lacks effective pharmacologic therapies. Although epithelial-mesenchymal transition (EMT) is central to PVR pathogenesis, the structural determinants governing the tractability of EMT regulators, particularly those involving intrinsic disorder, remain poorly defined. We developed a disorder-aware, artificial intelligence-enabled computational framework to evaluate EMT-associated proteins in PVR and prioritize structurally tractable regulators for structure-based targeting.

DESIGN: A computational, hypothesis-generating study employing an in silico screening and structural modeling pipeline.

SUBJECTS: No human subjects or biological specimens were included. The dataset comprised 25 EMT-associated proteins implicated in PVR, …

Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson

Medical Student Research Symposium

Background and Purpose: Mercury is a pervasive environmental contaminant, and human epidemiologic studies have linked chronic low-level exposure to increased autoimmune disease-risk. Dysregulated lymphocyte activation and impaired signaling tolerance are central mechanisms in human autoimmunity. Protein phosphorylation governs lymphocyte differentiation and function, alterations in phosphoproteomic networks may represent a signature of immune disruption. This study evaluates how low dose mercury exposure modifies B and T cell abundance and intracellular signaling patterns in BALB/c and Diversity Outbred (DO) mice.

Methods: BALB/c and DO mice were exposed to low dose HgCl2 in their water for two weeks or provided standard water controls. …

Difference Between Postural Sway, Functional Fitness, And Behavioral Measures In Older Adult Fallers & Non-Fallers, Olivia Maus, Rebecca Brandhorst, Andrea Geisenhof, Kyle Reason

InnovateHER Meeting 2026

BACKGROUND: Falls are among the leading causes of injury, hospitalization, and loss of independence among older adults. There is not enough research to determine how body composition, fitness, and postural sway affect balance.

METHODS: Participants completed surveys measuring behaviors around fall risk, assessment of body composition, postural sway, and functional fitness.

RESULTS: There was a significant difference between OF and ONF on the FES-I (p=0.05; d=-0.41) and the ABC-6 (p=0.008; d=0.57). There was significance on condition three of the mCTSIB (p=0.007; d=-.58), and composite score (p=0.04; d=-0.43).Significance between groups was approached on condition one of the mCTSIB (p=0.06; d=-0.39).

CONCLUSIONS: …

Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez

Psychology ETDs

Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …

Urobiome Composition Varies With Vesicoureteral Reflux Grade And History Of Febrile Urinary Tract Infection, Theresa C. Barrett, Kelvin Li, Adam Fitch, Asha Patel, Bhanu Sharma, Jacqueline Holden, Kermina Abdelsayed, Nina N. Kowalewski, Sridhar Narla, Daniel Bushnell, Barbara A. Methé, Catherine S. Forster

Department of Medicine Faculty Papers

Vesicoureteral reflux (VUR) is a risk factor for urinary tract infection (UTI). However, data describing the urobiome in children with VUR are limited. Here, we characterized the urobiome in children with and without VUR to better understand its potential role in VUR pathogenesis. Catheterized urine samples were obtained from children who presented for voiding cystourethrogram (VCUG) between 12/1/2020 and 10/3/2023. Children were excluded if they had any surgical procedures of the genitourinary tract in the 30 days prior to VCUG or were on treatment antibiotics at the time of VCUG. 16S rRNA gene sequencing and taxonomical classification identified the urobiome. …

Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam

UNLV Theses, Dissertations, Professional Papers, and Capstones

This secondary analysis study evaluated the effectiveness of Cognitive Stimulation Therapy (CST) on quality of life (QoL), depressive symptoms, and cognitive function in 108 community-dwelling older adults with cognitive impairments, including dementia. Outcomes involved Quality of Life (QoL) measured by the Quality of Life in Alzheimer’s Disease (QoL-AD), symptoms of depression by the Cornell Scale for Depression in Dementia (CSDD), and cognitive function using the Saint Louis University Mental Status (SLUMS). After the CST, significant improvements were observed in QoL (p = .004), depressive symptoms (p = .002), and cognitive function (p < .001), with small effect sizes. Additionally, a significant interaction between sex and dementia diagnosis status was found in predicting cognitive changes, suggesting that the relationship between dementia diagnosis and cognitive improvement differs by sex. No between-group differences were found for QoL or depression. Findings support CST as a multidimensional, non-pharmacological intervention that improves cognitive, psychological, and social outcomes. Although effects were small, consistent improvements are clinically meaningful given the progressive nature of dementia. This study extends existing literature by demonstrating CST’s effectiveness in a community-based setting and reinforces its alignment with occupational therapy’s emphasis on participation and holistic care. Results highlight the need for early intervention and expanded access to CST programs to enhance quality of life in this population.

Turf Toe And Sesamoid Fracture Case Study, Mason Cannon

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE This case presents the evaluation and management of a 15-year-old male multi-sport high school athlete. The athlete initially sustained a turf toe injury that progressed into a sesamoid fracture. This report showcases the clinical findings, treatment progression, and outcomes within a disablement model framework.

Prevalence Of Low Energy Availability (Lea) Risk In Division Iii Female Distance Athletes, Ciara Murphy

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE The objective of this study was to explore the prevalence of LEA among division III female distance athletes.

The Effectiveness Of An Educational Program On Young Swimmers Water Consumption And Dry Land Exercises, Maria Thibodeaux, Shelby Bay, Maddie Hoyt, Elizabeth Starns, Elizabeth Nix

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/CONTEXT Although shown to improve performance, many young swimmers are reluctant to participate in dry land exercises.¹ They are also more likely to become dehydrated than their non-swimming counterparts, suggesting they are not adequately hydrating during activity and throughout their day.² Therefore, this study aimed to evaluate the impact of a four-week educational program on dry land exercises and water consumption.

From Focal Chondral Defect To Matrix-Induced Autologous Chondrocyte Implantation In An Active Adult: A Case Study, Zoey Scott

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Present a clinical case detailing the undetermined consequential factors associated with FCD progression  in athletic populations, and the subsequent challenges.

Post-Surgical Dislocations: A Latarjet Procedure, Brianagh Dean, Kimberly S. Peer

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

BACKGROUND The glenohumeral joint is the most frequently dislocated joint in the body, with an incidence rate of 40.4 per 100,000 in men and 15.5 per 100,000 women. Recurrence rates following a first-time anterior shoulder dislocation range from 33-40%, particularly among adolescent collision-sport athletes. Arthroscopic Bankart repair is performed to address anterior instability, however recurrent instability may occur in the presence of glenoid bone loss. The Latarjet surgery is indicated in cases of recurrent anterior instability with significant bony deficiency, functioning through a triple-blocking mechanism increasing glenoid surface area via coracoid transfer, creating a dynamic sling effect from the conjoined …

Oral Contraceptives Rate Of Reduction On Anterior Cruciate Ligament Injuries In Females: A Critically Appraised Topic, Paige Trent, Sara Stiltner

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO Anterior cruciate ligament (ACL) injuries occur more frequently in females than males, with estimates suggesting a 2-10 greater likelihood of females to sustain this trauma.3 FIFA issued a recent call to action encouraging further investigation into why females are still predisposed to this trauma.2 ACL incident rate is highest amongst females between 14–18-years-old with approximately 227.6 exposures per 100,000 persons per year.1 Multifactorial influences are suggested as predisposing risk factors including anatomical or hormonal components.1 Growing interest in hormonal contributions has led researchers to examine how fluctuations in estrogen, progesterone, and testosterone impact ligamentous integrity.8

Estrogen receptors are …

Case Report: Chronic Peroneal Subluxation, Natalie Weissman, Morgan Cooper Bagley, Colin Reidy

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE The case study presented explores the sign, symptoms, and unique treatment of a patient with a chronic peroneal subluxation of the right ankle. The clinical evaluation showed full range of motion with visible peroneal tendon movement over the right lateral malleolus. Surgery was not done or recommended; a four-phase rehabilitation with a return to play protocol was used. This case showed how rehabilitation through a non-surgical approach is still achievable.

The Effect Of Taper On Scapular Positioning In Division Iii Collegiate Swimmers, Maddie Hoyt, Elizabeth Starns, Andrew Busch

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Scapular asymmetry and lateral translation are prevalent in competitive swimmers due to the repetitive overhead nature of the sport.^1,2 Additionally, ambiguity exists in the reliability of non-invasive scapular assessments. First, this study aimed to compare differences in scapular positioning during the competitive swimming season to the tapered season. The tapered season is marked by a significant decrease in intensity.^3,4,5 Second, this study aimed to determine the reliability of three commonly used scapular assessments.

Anterior Cruciate Ligament Autograft Reconstruction Outcomes In Adolescents And Young Adults: A Critically Appraised Topic, Klevione D. Brown, River A. Hamilton, Elizabeth A. Starns

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO Anterior cruciate ligament (ACL) tears are one of the most common serious knee injuries seen in high school and college-aged athletes.¹ Many athletes opt for surgical reconstruction because ACL injuries often result in knee instability and impair their ability to return to play in their sport.² There are three primary types of autografts used in reconstruction: bone-patellar tendon-bone (BTB), hamstring tendon (HT), and quadriceps tendon (QT) autografts.³ It is important to determine if a graft type has better return-to-play outcomes for adolescent and young adult athletes.

Sport-Related Concussion Incidents Across Sports, Surfaces, And Injury Mechanisms: A Retrospective Analysis Of A Digital Concussion Database, Justin Belle, Jay Alberts, Jason Cruickshank, Richard Figler, Kelsey Owen, Sami Rifat

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/CONTEXT Sport-related concussion (SRC) represents a significant injury burden in youth athletics. Advances in digital injury surveillance platforms allow for large-scale clinical databases that may provide insight into injury mechanisms, sport distribution, and management patterns. The purpose of this study was to describe the distribution of concussion-related incidents across sports, playing surfaces, and mechanisms of injury using data from a prospectively maintained clinical concussion database.

Dysautonomia In Adolescent Athletes With Persistent Post‑Concussion Complaints, Jason A. Cruickshank

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/BACKGROUND Dysautonomia is dysfunction in autonomic nervous system manifesting following concussion, contributing to Persistent Post‑Concussion Complaints (PPCC).^1,5 Patients with dysautonomia may present with dizziness, tachycardia, postural intolerance, headaches, cognitive fog, and activity/exercise intolerance.^1,5 Recognition of autonomic involvement is essential to recovery and preventing prolonged symptoms^.1,5

The Effectiveness Of A Mental Health Literacy Webpage For Parents, Coaches, And Athletic Trainers, Mackenzie Warner, Kimberly Peer, Hannah Harnar, David Dees

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

INTRODUCTION Mental health illnesses continue to emerge as a major public health concern, particularly among adolescents and young adults. Secondary school student-athletes face unique pressures related to academics, athletic performance, time management, injuries, and social expectations, all of which may contribute to anxiety, depression, stress, or other mental health conditions. However, there is limited research that explores secondary school student-athletes and how mental health affects their everyday lives. This could be due to the lack of mental health literacy in the individuals who surround secondary school student-athletes, including parents, coaches, and athletic trainers. Increasing their understanding of mental health literacy …

Understanding Athletic Trainer's Knowledge And Perceptions Of Mental Health Best Practices: A Mixed-Methods Study, Chelsea Pasukinis, Yvette Ingram, Malissa Martin, Robert B. Krueger

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE Mental health disorders are increasing in our society. Research on athletic trainers' (AT) knowledge and perception of mental health disorders, and whether policies are developed and used, is limited. The purpose of this study is to investigate AT’s knowledge of mental health illness, current policies and procedures, and the perceptions ATs have of mental health.

A Case Report Of Blunt Renal Trauma In A High School Football Athlete, Mariah Reeder

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE/BACKGROUND Blunt abdominal trauma in football athletes is uncommon but carries significant risk for internal organ injury and hemorrhage. Although sport-related renal injuries are rare, a significant portion of them are high-grade (IV-V) and may require advanced medical intervention if not recognized promptly.¹ Symptoms may initially appear benign, such as “having the wind knocked out,” increasing the risk of delayed diagnosis. Athletic trainers often serve as first responders and play a critical role in early recognition, on-field management, and prompt referral for advanced medical care. This case highlights athletic trainer led clinical decision making and interdisciplinary coordination following blunt …