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Articles 13351 - 13380 of 14898

Full-Text Articles in Medical Specialties

Editorials Mar 1983

Editorials

Henry Ford Hospital Medical Journal

No abstract provided.

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The Role Of Major Hepatic Resections For Liver Metastases From Colorectal Cancer, Angelos A. Kambouris Mar 1983

The Role Of Major Hepatic Resections For Liver Metastases From Colorectal Cancer, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

Of the more than 120,000 new patients with colorectal cancer in 1982, at least 20% will develop liver metastases either at initial presentation or after treatment of the primary lesion. The median survival in such patients has been variously estimated at between five and nine months, and in spite of treatment by chemotherapeutic agents, only rarely do such patients survive five years. By contrast, patients who survive the longest after treatment of liver metastases from colorectal cancer have had major hepatic resections alone or combined with chemotherapy as part of their management. The present report describes five patients who were …

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Clinical Note: Excision Of A Large Ovarian Leiomyoma In A Centenarian, James A. Sapala, M. Andrew Sapala Mar 1983

Clinical Note: Excision Of A Large Ovarian Leiomyoma In A Centenarian, James A. Sapala, M. Andrew Sapala

Henry Ford Hospital Medical Journal

Leiomyoma of the ovary is a rare neoplasm; only 28 cases in the literature are known to us. In 1979, we encountered a tumor of this type and are reporting it here because of its great size and its occurrence in a 103-year-old woman. The patient has been well for two years since the tumor was removed.

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The Role Of Splenectomy In Endocarditis, Donald J. Magilligan Jr., Edward L. Quinn Mar 1983

The Role Of Splenectomy In Endocarditis, Donald J. Magilligan Jr., Edward L. Quinn

Henry Ford Hospital Medical Journal

Five patients with endocarditis, persistent sepsis, and positive liver-spleen scans underwent splenectomy. Three had splenectomy performed concomitantly with cardiac valve replacement, one after valve replacement and one as an isolated procedure. Four of five spleens contained abscesses, and bacterial cultures of two were positive. Histologic study of one spleen revealed splenitis. All patients improved after splenectomy, and all are well two to twenty months postoperatively. An aggressive approach to splenic abscess in endocarditis may lead to reduced mortality from bacterial endocarditis and infected prosthetic valves.

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Front Matter Mar 1983

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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The Regional Acceleratory Phenomenon: A Review, Harold M. Frost Mar 1983

The Regional Acceleratory Phenomenon: A Review, Harold M. Frost

Henry Ford Hospital Medical Journal

The regional acceleratory phenomenon (RAP) is a complex reaction of mammalian tissues to diverse noxious stimuli. The phenomenon occurs regionally in the anatomical sense, involves both soft and hard tissues, and is characterized by an acceleration and domination of most ongoing normal vital tissue processes. It may represent an "SOS" mechanism which evolved to potentiate tissue healing and local tissue defensive reactions. When a RAP is obtunded, retarded healing and lowered resistance to infection and mechanical abuse may ensue. When ignored in experimental design, the phenomenon can seriously perturb studies of metabolic bone disease and of the effects of mechanical, …

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The Acquired Double Pylorus, Klaus Anselm, Arthur H. Halprin Mar 1983

The Acquired Double Pylorus, Klaus Anselm, Arthur H. Halprin

Henry Ford Hospital Medical Journal

Four patients with the double pylorus are reported. In view of an earlier history of peptic ulcer disease, the double pylorus is considered to have been acquired in all four. The literature involving 54 reported cases is reviewed, and the natural history of the double pylorus is discussed.

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Endoscopic Sclerotherapy In The Treatment Of Recurrent Bleeding From Esophageal Varices, Martin C. Zonca, Dominic K. H. Wong, Surinder K. Batra, Bernard M. Schuman Mar 1983

Endoscopic Sclerotherapy In The Treatment Of Recurrent Bleeding From Esophageal Varices, Martin C. Zonca, Dominic K. H. Wong, Surinder K. Batra, Bernard M. Schuman

Henry Ford Hospital Medical Journal

Endoscopic sclerotherapy as a method to treat bleeding esophageal varices was first performed by Crafoord and Erenckner in 1939 but was not widely accepted. Surgical therapy, using the portocaval shunt, became the preferred method of preventing hemorrhage from bleeding varices. Over the years, enthusiasm for the surgical approach has waned because the mortality rate with certain patients is prohibitively high. Conversely, interest in endoscopic sclerotherapy is growing as a result of several favorable reports. We present our initial experience with this procedure in the management of patients with bleeding esophageal varices.

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Management Of Colonic Trauma: Six-Year Experience At Henry Ford Hospital, Farouck N. Obeid, Victor Sorensen, Gilford Vincent, Deepak Vij, H. Mathilda Horst, D. Paul Horan Mar 1983

Management Of Colonic Trauma: Six-Year Experience At Henry Ford Hospital, Farouck N. Obeid, Victor Sorensen, Gilford Vincent, Deepak Vij, H. Mathilda Horst, D. Paul Horan

Henry Ford Hospital Medical Journal

Surgical management of 114 patients with colonic injuries related to trauma who were treated over a six-year period is reviewed. Eighty-three (73%) injuries were secondary to gunshot wounds. Twenty-six patients (24%) had isolated colonic injuries. The majority of patients (60%)) were treated with colostomies: exteriorization of the injury, repair with proximal colostomy, or resection with colostomy and mucous fistula. Exteriorization of repaired colon, primary repair, and resection with primary anastomosis were performed in 40% of the patients. Six patients (5.3%) in our series died, and 24% had complications directly related to the colon injury. Based on this study, no standard …

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The Other Breast: Indications For Biopsy And/Or Mastectomy, Charles S. Rogers Mar 1983

The Other Breast: Indications For Biopsy And/Or Mastectomy, Charles S. Rogers

Henry Ford Hospital Medical Journal

A search for malignant and premalignant lesions in 162 contralateral biopsy and/or mastectomy specimens yielded 45 (27.8%,) malignancies and 54 (33%) premalignant lesions (atypical epithelial hyperplasia, Wellings grades III and IV). In those with no palpable or mammographic suspicion of malignancy, the cancer incidence was 73.8%. Eight malignancies occurred one month to three years after antecedent biopsies which revealed premalignant lesions. No cancer has been detected after biopsies which revealed hyperplasia of grade II or less. Cancer size at time of discovery varied significantly with the method of detection: average 2.7 cm by palpation; 1.6 cm by mammography; 0.5 cm …

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Current Concepts In Otitis Media, Michael M. Paparella Mar 1983

Current Concepts In Otitis Media, Michael M. Paparella

Henry Ford Hospital Medical Journal

Otitis media continues to be a common and disabling problem which has become, in recent years, a fertile area for research. Based on studies in animals and humans, otitis media is classified into four groups: acute purulent otitis media (POM), serous otitis media (SOM), and mucoid or secretory otitis media (MOM). Together, these are referred to as otitis media with effusion (OME). The types can overlap and evolve into another type to become chronic otitis media and mastoiditis, characterized by the presence of granulation tissue or cholesteatoma. The biochemistry, microbiology, and pathology as well as clinical features of the disease …

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How Useful Is Peritoneal Lavage Amylase?, Eugene Meyer, James C. Gruenberg Mar 1983

How Useful Is Peritoneal Lavage Amylase?, Eugene Meyer, James C. Gruenberg

Henry Ford Hospital Medical Journal

Prospectively for 23 months, 289 patients with penetrating and 317 patients with blunt trauma to the lower chest and/or abdomen had amylase determinations in the peritoneal lavage as part of their initial evaluation. In nine (1.5%) of the 606 patients, the amylase in the lavage was higher than normal serum values and, when elevated, it identified intra-abdominal injury. Intra-abdominal injuries usually involved a hollow viscus injury—either isolated or combined with solid organ injuries—rather than pancreatic injury. Although elevation of the lavage amylase was a reliable indication of intra-abdominal injury in this series, we feel that routine use of this test …

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Therapeutic Hemapheresis, Sheikh M. Saeed, B. K. S. Raman Mar 1983

Therapeutic Hemapheresis, Sheikh M. Saeed, B. K. S. Raman

Henry Ford Hospital Medical Journal

No abstract provided.

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Back Matter Mar 1983

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Protein Contributions Of The Male Accessory Organs To The Composition Of Human Seminal Plasma As Determined By High Resolution Two-Dimensional Electrophoresis, Edward E. Gaunt Jan 1983

Protein Contributions Of The Male Accessory Organs To The Composition Of Human Seminal Plasma As Determined By High Resolution Two-Dimensional Electrophoresis, Edward E. Gaunt

Theses and Dissertations in Biomedical Sciences

Human Seminal Plasma was evaluated using a High Resolution Two-Dimensional Electrophoresis technique adapted by this laboratory. Seminal plasma from healthy volunteers with recently proven fertility were characterized using this technique to establish "normal" protein distribution patterns in the two-dimensional polyacrylamide gel slab. In addition, time studies were performed on selected specimens to determine the effects of liquefaction on seminal plasma protein composition within the first several hours after collection. Split ejaculates were collected for identification and elaboration of accessory organ components in the whole seminal plasma specimen. A more direct approach to accessory organ component analysis involved electrophoresis of semen …

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Serial Cardiovascular Adaptations During Pregnancy, Mark Vincent Hart Jan 1983

Serial Cardiovascular Adaptations During Pregnancy, Mark Vincent Hart

Dissertations and Theses

Maternal cardiovascular adaptations appear to be essential in order to supply extra circulation to both the developing fetus and maternal system during a successful pregnancy. Since inadequate cardiovascular adjustments may produce abortions or maternal morbidity, the characterization of maternal cardiovascular changes during pregnancy and the elaboration of the underlying mechanism for these changes are essential to the understanding of how the heart enlarges during pregnancy and what significance this enlargement might have. To provide needed information regarding this time course and extent of maternal cardiac enlargement and the hormonal and hemodynamic changes which may be responsible for these changes, the …

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Front Matter Dec 1982

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Hyperviscosity Syndrome Complicating Rheumatoid Arthritis: Report Of Two Additional Cases And Review Of The Literature, Michael R. Lovy, Mark C. Kranc, Gilbert B. Bluhm, Jeanne M. Riddle, Paul D. Stein Dec 1982

Hyperviscosity Syndrome Complicating Rheumatoid Arthritis: Report Of Two Additional Cases And Review Of The Literature, Michael R. Lovy, Mark C. Kranc, Gilbert B. Bluhm, Jeanne M. Riddle, Paul D. Stein

Henry Ford Hospital Medical Journal

A hyperviscosity syndrome developed in two patients with rheumatoid arthritis. Analytic ultracentrifugation of the sera from one patient demonstrated 22S complexes. Intermediate, 22S, and 31S complexes were found in the second case. Platelet aggregometry and electron microscopy surveys of the platelet reactivity in one patient demonstrated inhibition of platelet reactivity caused by the presence of the high molecular weight complexes. These abnormalities, as well as the clinical bleeding, whole blood, and plasma viscosity, became normal after treatment. In vivo leukocytic function was studied with the Rebuck skin window technique, and phagosomal inclusions were observed in both the polymorphonuclear neutrophils and …

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Re: Abbs, Conrad R. Lam Dec 1982

Re: Abbs, Conrad R. Lam

Henry Ford Hospital Medical Journal

No abstract provided.

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The Measurement Of Human Chorionic Gonadotropin For Pregnancy Testing, Carolyn S. Feldkamp, William H. Pfeffer Dec 1982

The Measurement Of Human Chorionic Gonadotropin For Pregnancy Testing, Carolyn S. Feldkamp, William H. Pfeffer

Henry Ford Hospital Medical Journal

/Among many measurable hormones, human chorionic gonadotropin (FICG) is commonly used for pregnancy testing because it is very sensitive and relatively specific. Pregnancy can be identified shortly after implantation. Because some reagents cross-react with luteinizing hormone (LH), the sensitivity of urine tests has been adjusted to maintain specificity. Radioreceptor assay s on serum are more sensitive than urine tests but similarly lack specificity. The problems of LH cross-reactivity are eliminated by antisera specific for the beta subunit. Quantitation of HCG provides additional information useful in diagnosing ectopic pregnancy, providing a prognosis in threatened abortion, and following neoplasms. Considerations of cost, …

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Primary Hyperparathyroidism: The Continuing Saga Of Surgical Problems, Melvin A. Block Dec 1982

Primary Hyperparathyroidism: The Continuing Saga Of Surgical Problems, Melvin A. Block

Henry Ford Hospital Medical Journal

Continuing problems in the management and surgical treatment of primary hyperparathyroidism include the localization of the elusive single tumor, the recognition and management of multiple gland involvement, prompt confirmation and operative treatment for hypercalcemic crisis, delineation of a liberal but selective policy relative to surgery for apparent uncomplicated hyperparathyroidism in the elderly, and recognition of the surgeon's responsibility to determine the extent of the operation on the basis of operative findings, realizing that histologic study may not confirm apparent gross abnormalities despite subsequent clinical recovery. When all four glands are involved in primary hyperparathyroidism, subtotal parathyroidectomy is recommended except for …

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Echocardiographic Identification Of Left Ventricular Cavity Obliteration, Vidyadhar R. Gandra, Mohsin Alam, Fareed Khaja, Sidney Goldstein, Jeffrey B. Lakier Dec 1982

Echocardiographic Identification Of Left Ventricular Cavity Obliteration, Vidyadhar R. Gandra, Mohsin Alam, Fareed Khaja, Sidney Goldstein, Jeffrey B. Lakier

Henry Ford Hospital Medical Journal

We identified 22 patients with angiographic left ventricular cavity obliteration (LVCO), of whom 15 were available for M-mode and two-dimensional echocardiographic evaluation. All 15 patients had chest pain, and 13 had long-standing hypertension. Electrocardiographic evidence of left ventricular hypertrophy was present in ten patients. The echocardiographic criterion for LVCO was apposition of the left ventricular septum with the left ventricular posterior endocardium during systole as demonstrated by either M-mode or two-dimensional systems. LVCO was demonstrated during systole by M-mode echocardiography in seven of 15 patients and by two-dimensional echocardiography in 14 patients. LVCO could not be demonstrated in ten randomly …

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Back Matter Dec 1982

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Assessment Of The Orifice Area Of Bioprosthetic Valves By Orifice-View Roentgenography, Paul D. Stein, James F. Brymer, Daniel T. Anbe, Hani N. Sabbah, Gordon M. Folger Jr. Sep 1982

Assessment Of The Orifice Area Of Bioprosthetic Valves By Orifice-View Roentgenography, Paul D. Stein, James F. Brymer, Daniel T. Anbe, Hani N. Sabbah, Gordon M. Folger Jr.

Henry Ford Hospital Medical Journal

Orifice-view angiography permits us to visualize en face the orifice of the aortic or mitral valve. The radiopaque annulus of bioprosthetic valves assists in permitting the angiographer to position the patient exactly, so that the valve can be seen as if looking directly into the orifice. Orifice-view angiography of porcine bioprosthetic valves has been useful in assessing the size and configuration of the valve orifice. It can reveal a failure of leaflet opening that would indicate degeneration, even when hemodynamic measurements remain equivocal.

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Natural History Of The Porcine Bioprosthetic Heart Valve, Donald J. Magilligan Jr., Joseph W. Lewis Jr., J. Lancelot Lester Iii, Paul D. Stein, Mohsin Alam, Jeffrey B. Lakier, Julio C. Davilia, David W. Smith Sep 1982

Natural History Of The Porcine Bioprosthetic Heart Valve, Donald J. Magilligan Jr., Joseph W. Lewis Jr., J. Lancelot Lester Iii, Paul D. Stein, Mohsin Alam, Jeffrey B. Lakier, Julio C. Davilia, David W. Smith

Henry Ford Hospital Medical Journal

The porcine bioprosthesis has been the prosthetic valve of choice at Henry Ford Hospital since October 1971. By 1979, 23 cases of degeneration had been seen, and the rate seven years after implantation was 16%. Now, with a ten-year follow-up, there are 41 degenerated valves. After seven years, the percent free of degeneration is 88%, (SE of 2% [standard error]); at eight years, 82% (SE of 2.9%,); at nine years, 80% (SE of 3.4%); and at ten years, the percent free of degeneration is 69% (SE of 6.5%,). There was no difference in degeneration between men and women, between aortic …

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Front Matter Sep 1982

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

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Studies On Porcine Bioprosthetic Heart Valves At Henry Ford Hospital: An Overview, Paul D. Stein Sep 1982

Studies On Porcine Bioprosthetic Heart Valves At Henry Ford Hospital: An Overview, Paul D. Stein

Henry Ford Hospital Medical Journal

No abstract provided.

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Frequency Content Of Heart Sounds And Systolic Murmurs In Patients With Porcine Bioprosthetic Valves: Diagnostic Value For The Early Detection Of Valvular Degeneration, Paul D. Stein, Hani N. Sabbah, Jeffrey B. Lakier, Stephen R. Kemp, Donald J. Magilligan Jr. Sep 1982

Frequency Content Of Heart Sounds And Systolic Murmurs In Patients With Porcine Bioprosthetic Valves: Diagnostic Value For The Early Detection Of Valvular Degeneration, Paul D. Stein, Hani N. Sabbah, Jeffrey B. Lakier, Stephen R. Kemp, Donald J. Magilligan Jr.

Henry Ford Hospital Medical Journal

The frequency content of heart sounds and murmurs in patients with implanted bioprosthetic valves may reveal evidence of degenerative changes before such changes are clinically apparent. An increased dominant frequency of the heart sound caused by a bioprosthetic valve in either the aortic or mitral positions suggests stiffening of the leaflets. While a musical systolic murmur of a bioprosthetic valve in the mitral position suggests flutter from a torn, insufficient leaflet, limited observations of musical systolic murmurs in the aortic position do not seem to indicate a degenerated valve.

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Fluid Dynamic Stresses In The Region Of A Porcine Bioprosthetic Valve, Hani N. Sabbah, Paul D. Stein Sep 1982

Fluid Dynamic Stresses In The Region Of A Porcine Bioprosthetic Valve, Hani N. Sabbah, Paul D. Stein

Henry Ford Hospital Medical Journal

Mechanical forces caused by the dynamics of blood flow in the region of porcine bioprosthetic valves may directly injure the valve as well as formed elements of the blood. Previous in vitro studies in our laboratory evaluated quantitatively the fluid dynamic stresses in the region of such valves. In this paper we discuss our results in relation to fluid dynamic stresses found in patients with normal and diseased natural aortic valves. The levels of fluid dynamic stresses that may produce mechanical injury to erythrocytes and platelets are reviewed. These may indicate the extent to which fluid dynamic stresses may activate …

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Immunological Involvement In Porcine Bioprosthetic Valve Degeneration: Preliminary Studies, Rollin H. Heinzerling, Paul D. Stein, Jeanne M. Riddle, Donald J. Magilligan Jr., John J. Jennings Sep 1982

Immunological Involvement In Porcine Bioprosthetic Valve Degeneration: Preliminary Studies, Rollin H. Heinzerling, Paul D. Stein, Jeanne M. Riddle, Donald J. Magilligan Jr., John J. Jennings

Henry Ford Hospital Medical Journal

Preliminary animal model studies have indicated that porcine bioprosthetic valves can be recognized by the immune system. This report presents the results of a preliminary investigation on the implanted valves of 27 patients. While none of the 27 demonstrated an immune response to porcine serum proteins, five patients developed antibodies against the implanted valve leaflets. Cells were enzymatically eluted from a degenerated bioprosthetic valve and were classified by means of monoclonal antibodies. Although these cells were not found to be of T-lymphocyte lineage, they did express la determinants and had the morphologic appearance of plasma cells. We therefore conclude that …

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