Medical Specialties Commons^™

Global Burden Of Atherosclerotic Cardiovascular Disease In People With Hepatitis C Virus Infection: A Systematic Review, Meta-Analysis, And Modelling Study, Kuan Ken Lee, Dominik Stelzle, Rong Bing, Mohamed Anwar, Fiona Strachan, Sophia Bashir, David E. Newby, Jasmit Shah, Michael Chung, Gerald S. Bloomfield

Internal Medicine, East Africa

Background: More than 70 million people worldwide are estimated to have hepatitis C virus (HCV) infection. Emerging evidence indicates an association between HCV and atherosclerotic cardiovascular disease. We aimed to determine the association between HCV and cardiovascular disease, and estimate the national, regional, and global burden of cardiovascular disease attributable to HCV.

Methods: For this systematic review and meta-analysis, we searched MEDLINE, Embase, Ovid Global Health, and Web of Science databases from inception to May 9, 2018, without language restrictions, for longitudinal studies that evaluated the risk ratio (RR) of cardiovascular disease in people with HCV compared with those without …

Oral Delivery Of Xenon For Cardiovascular Protection, Xing Yin, Melanie R Moody, Valeria Hebert, Melvin E Klegerman, Yong-Jian Geng, Tammy R Dugas, David D Mcpherson, Hyunggun Kim, Shao-Ling Huang

Faculty, Staff and Student Publications

Cardiac hypertrophy often causes impairment of cardiac function. Xenon (Xe), a naturally occurring noble gas, is known to provide neurological and myocardial protection without side effects. The conventional method of Xe delivery by inhalation is not feasible on a chronic basis. We have developed an orally deliverable, effective Xe formulation for long-term administration. We employed 2-hydroxypropyl)-β-cyclodextrin (HPCD), which was dissolved in water to increase the Xe concentration in solution. The beneficial effects of long-term oral administration of Xe-enriched solutions on cardiovascular function were evaluated in vivo. HPCD increased Xe solubility from 0.22 mM to 0.67 mM (3.8-fold). Aged ApoE knockout …

Abdominal Tb, More To Abdominal Masses And Symptoms Than Meets The Eye, Johnathon Dallarosa Md, Breanna S. Goldner Do

Department of Medicine

No abstract provided.

A Rare Case Of Biliary Pancreatitis Caused By Ampullary Somatostatinoma In A 46-Year-Old Female, Michal Kloska Md, Phd, Reema M. Vaze Md, Ricky Buckshaw Do, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Endoscopic Ultrasound-Guided Drainage Of Pancreatic Fluid Collections Using Axios™ Electrocautery Enhanced Delivery System: A Retrospective Experience At A Large Quaternary Care Center, Michal Kloska Md, Phd, Valery Hrad Md, Soorya N. Aggarwal Do, Shashin Shah Md, Zachary Zator Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Management Of Large Aspergilloma With Massive Hemoptysis Complicated By Adhesions From A Previous Partial Lobectomy, Johnathon Dallarosa Md, Nathan Brewster Do, Brian J. Holahan Do, Kareem Godil Md, Jaimin Patel Do, Jessica Boehmler Md

Department of Medicine

No abstract provided.

69-Year-Old Male After Gastric Bypass With Choledocholithiasis Treated With Edge Procedure Complicated By Lams Dislocation, Michal Kloska Md, Phd, Reema M. Vaze Md, Ricky Buckshaw Do, Hiral N. Shah Md

Department of Medicine

No abstract provided.

Umbilical Hernia Rupture Complicated By Enterocutaneous Fistula In 63-Years-Old Female With Decompensated Nash Cirrhosis, Michal Kloska Md, Phd, Matthew J. Sullivan Do, Adam Peyton Do, Waqas Adeel

Department of Medicine

No abstract provided.

Bile Reflux Gastritis Patient Profile In Dr. Saiful Anwar Malang Hospital, Fadhila Nurisa, Supriono Supriono

Jurnal Penyakit Dalam Indonesia

Introduction. Bile reflux gastritis is bile reflux to gaster with fullness sensation, uncomfort, nausea, and vomiting. Bile reflux gastritis usually happens after surgery, as partial gastrectomy, truncal vagotomy, pyloroplasty, cholecystectomy, or sphinchteroplasty. This study aimed to determine the description of endoscopic of patients with bile reflux gastritis and the location of abnormalities found in endoscopy patient at Saiful Anwar Hospital Malang. Methods. Data were taken from the medical record of endoscopy patient in Saiful Anwar Hospital Malang from 2012 January the 1st until 2016 December the 31st that fulfill bile reflux gastritis inclusion criteria. Abnormality location divided near and far …

Neutrophil Lymphocyte Ratio As A Predictor Of The First Onset Acute Neutropenia After R-Chop Chemotherapy In Diffuse Large B-Cell Lymphoma Patients, Griskalia Christine, Lugyanti Sukrisman, Noorwati Sutandyo, Cleopas Martin Rumende

Jurnal Penyakit Dalam Indonesia

Background. Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoma in Indonesia. R-CHOP chemotherapy has a moderate risk for neutropenia / febrile neutropenia. Lymphocytes can describe host immunity, while neutrophils and monocytes can describe the inflammatory response. No study has assessed differential count of leukocytes as a predictor of the first onset acute neutropenia after R-CHOP chemotherapy in DLBCL patients. This study aimed to determine the relationship between differential count of leukocytes before chemotherapy as a predictor of the first onset acute neutropenia after R-CHOP chemotherapy in DLBCL patients. Methods. A retrospective cohort study was conducted among 18–60 years …

The Additive Effect Of Rosmarinic Acid For The Reduction Of Glomerular Nf-Kb Expression In Diabetes Rat That Was Given Telmisartan, Mochamad Fachrureza, Nur Samsu, Achmad Rudijanto

Jurnal Penyakit Dalam Indonesia

Introduction. Diabetic nephropathy is one of the common complications of diabetes, which one of its causes is the increase of free radicals through the activation of NF-kβ and Angiotensin II. Rosmarinic acid has the activity as the anti-oxidant and anti-inflammatory, and the telmisartan is the partial PPAR-γ agonist that has the anti-fibrotic effect. This study aimed to identify the effect of rosmarinic acid and telmisartan in the reduction of subunit p65 NF-kB expression on the glomerular diabetes rat. Methods. An experimental study with a post-test only controlled group was conducted in a group of rats (Rattus norvegicus). Rats were randomly …

Factors Affecting Rapid Decline In Glomerular Filtration Rate In Hiv/Aids Patients Using Tenofovir Disoproxil Fumarate, Prima Yuriandro, Evy Yunihastuti, Maruhum Bonar H Marbun, Pringgodidgo Nugroho

Jurnal Penyakit Dalam Indonesia

Introduction. Tenofovir disoproxil fumarate (TDF) treatment in HIV/AIDS patient has particular effect to the kidney, which is rapid decline in glomerular filtration rate (GFR) (> 5 cc/min/1.72 m2 one year after using the drug). The incidence rate for rapid decline in GFR and factors affecting it are still contradictive and not assessed completely. This study was done to identify cumulative incidence and factors affecting TDF related nephrotoxicity. Methods. A retrospective cohort study was conducted in HIV/AIDS outpatient clinic Cipto Mangunkusumo Hospital Jakarta. We included patients who start taking TDF as their medication from January 2010 until January 2015 with consecutive …

Arterial And Venous Thrombosis In Patients With Myeloproliferative Neoplasms, Lugyanti Sukrisman

Jurnal Penyakit Dalam Indonesia

Introduction. Myeloproliferative neoplasm (MPN) is a hematologic disorder that consists of polycythemia vera (PV), essential thrombocythemia (ET and primary myelofibrosis (PMF) and complication of thrombosis is frequently found in patients with MPN. This study was conducted to observe complication of thrombosis in patients with MPN. Methods. A descriptive study was conducted among patients with MPN at MMC Hospital. Clinical data was obtained from medical records of patients with MPN who sought treatment with investigator between 2010 and 2018 and the data was collected consecutively. Evaluation on JAK2 mutation was performed at either the Research and Development Laboratory of Dharmais Cancer …

Meningoensefalitis Manifestation In Wegener’S Granulomatosis With Anca Negative: Case Report, Triyanti Kurniasari Ananta Putri Sudibyo, Deshinta Putri Mulya, Eko Budiono, Sekar Satiti, Levina Prima Rosalia

Jurnal Penyakit Dalam Indonesia

Wegener’s granulomatosis is a vasculitis that affects small to medium blood vessels, generally occurring at the age of 64- 75 years with an incidence of 8-10 / 1,000,000 people. Meningoencephalitis manifestations are rarely found in Wegener’s granulomatosis with the incidence only in the range of 0-7%. Anti-neutrophil cytoplasmic antibody (ANCA) is often used in diagnosing Wegener’s granulomatosis, but negative ANCA can be found in 10-20% of cases. A 30-year-old man came with a decrease in consciousness. His anamnesis and physical examination showed signs that led to Wegener’s granulomatosis, despite negative ANCA examination results. After getting therapy according to the management …

Tenofovir Dan Gangguan Fungsi Ginjal Pada Hiv, Ni Made Hustrini

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Polycythemia: A Clinical Approach, Rahmat Cahyanur, Ikhwan Rinaldi

Jurnal Penyakit Dalam Indonesia

Polycythemia or erythrocytosis is an increase in the number of red blood cells in circulation marked by the increase in hematocrit. Polycythemia is a case that still raises questions and dilemma for doctors. In this paper, it will be discussed about the diagnostic approach and management of polycythemia. The initial complaints of polycythemia are generally nonspecific, such as weakness and dizziness due to blood hyperviscosity. It is also essential to know accompanying diseases, routine medications, habits, and family histories of the patients. Patients with polycythemia commonly exhibit plethora. In vital sign examination, hypertension can be found in polycythemia vera. In …

Use Of Clinical Parameters And Strain Echocardiography To Predict Stenosis Severity Based On Gensini’S Score In Stable Coronary Artery Disease, Arif Sejati, Idrus Alwi, Muhadi Muhadi, Hamzah Shatri

Jurnal Penyakit Dalam Indonesia

Introduction. In patient with stable coronary artery disease (CAD), severity of stenosis is closely related to prognosis. It is known that several clinical parameters and recently-developed strain echocardiography can predict severity of stenosis. Assessment of clinical parameters, altogether with strain echocardiography is expected to make better prediction. This study aim to determine whether clinical factors, i.e. age, sex, diabetes, typical angina, and history of myocardial infarction, and strain echocardiography parameter, i.e. global longitudinal strain (GLS), can predict severity of coronary artery stenosis measured with Gensini score,and to further develop a prediction model based on significant parameters. Methods. This is a …

A Coronary Masquerade: Spontaneous Coronary Dissection Presenting As Acute Coronary Syndrome, Kara Stout Do, Stephanie Cochran Do, Abdullah Rathur Do, Joe Carragher Do, Iftekhar Baig Do, Merrill Krolick Do

Cardiology

No abstract provided.

Unexpected Diagnosis, Gauravpal S Gill, Rukma R Govindu, Ragai Fouda, Hussam M Ammar

Faculty, Staff and Student Publications

A 74-year-old man presented to the ER with an eight-month history of shortness of breath, cough, anorexia, and weight loss. He had emigrated from sub-Saharan African to the USA, where he was diagnosed and treated for coronary artery disease, heart failure, and stroke; was hospitalized several times; and underwent hernia surgery. Despite the complex care that he received in the USA for many years, the diagnosis of AIDS was continually missed for years, and the patient was eventually diagnosed at the age of 74.

An Unusual Case Of Small Bowel Obstruction Secondary To Calcium Carbonate Use, Selsabeel Elyaman, Uma Gudur Md, Hady Khalifa, Alan Hamza, Andrew Seevaratnam Md

Gastroenterology

A Gastric Bezoar is defined as an accumulation of indigestible foreign material found in an individual’s GI tract. The incidence of gastric bezoar is 0.3% as reported by endoscopy studies. These formations usually consist of insoluble vegetable matter (phytobezoars), hair (trichobezoars), or medications (pharmacobezoar). In general, they can be asymptomatic for many years or cause nonspecific symptoms including abdominal pain, early satiety, and weight loss. However, in recent years, these have become increasingly problematic for the general population attributing to a variety of GI disturbances. We are reporting a case which revolves around a female patient with no history of …

Anxiety Induced Pulmonary Edema: A Rare Occurrence, Anum Akhlaq Md, Neda Shahoori, Alexandra Mary Kelada, Aftab Ahmad

Internal Medicine

No abstract provided.

Sensorimotor Polyneuropathy As The Initial Presentation Of Sarcoidosis: A Case Report Of A Rare Manifestation, Melanie Rojas, Lakshpaul Chauhan Md, Arshad M. Iqbal Md, Sadia Tufail, Nikolay Mitzov

Internal Medicine

No abstract provided.

Blue Rubber Bleb Nevus Syndrome, Danielle Kocsis, Anthony Dupuy, Stacey Wice, Aftab Ahmad, Tehmina Yaquibi

Internal Medicine

No abstract provided.

Nitrofurantoin Induced Lung Toxicity: A Rare Adverse Effect, Farrah Chilet Md, Nour Tlimat Md, Salman Muddassir Md

Internal Medicine

No abstract provided.

Nivolumab Induced Myasthenia Gravis, Elizabeth Henderson Md, Imad Ikhawn Md, Dharti R. Patel Md, Monicka Felix

Internal Medicine

No abstract provided.

Cutaneous Leishmaniasis In A Traveler: A Case Report, Sarah Al-Obaydi Md, Nemer Dabage Md, James Demaio Md

Internal Medicine

Leishmaniasis, a vector-borne infection transmitted by sandflies, is endemic throughout the Mediterranean basin and the tropics. We present a case diagnosed in Florida after overseas travel.

Don’T Be Blind To The Diagnosis: An Intriguing Case Of Monocular Blindness, Kourtney Erickson Do, Kaitlyn L. Buzard Do, Daniel Tseytlin Do, Carolyn Casey Do, Eugene Alexandrin Md

Department of Medicine

No abstract provided.

Bayesmetab: Treatment Of Missing Values In Metabolomic Studies Using A Bayesian Modeling Approach, Jasmit Shah, Guy N. Brock, Jeremy Gaskins

Internal Medicine, East Africa

Background: With the rise of metabolomics, the development of methods to address analytical challenges in the analysis of metabolomics data is of great importance. Missing values (MVs) are pervasive, yet the treatment of MVs can have a substantial impact on downstream statistical analyses. The MVs problem in metabolomics is quite challenging and can arise because the metabolite is not biologically present in the sample, or is present in the sample but at a concentration below the lower limit of detection (LOD), or is present in the sample but undetected due to technical issues related to sample pre-processing steps. The …

Geriatric Hepatology: The Hepatic Diseases Of The Elderly And Liver Transplant, Shima Ghavimi, Hamed Azimi, Neel Patel, Oleg Shulik

Internal Medicine

Introduction: With the aging US population, chronic liver diseases are becoming more commonly diagnosed in the geriatric population. Advanced age leads to changes in liver blood flow, volume, morphology and normal physiology. This predisposes elderly patients to develop certain chronic liver diseases. Also, the clinical course and management differ in an older patient when compared to a younger patient. Some causes of chronic liver disease in the geriatric population include Hepatitis A, B, C, Non-Alcoholic Fatty liver disease, prolonged alcohol use and inflammation. Many chronic liver diseases are characterized by a slow, indolent course of progression with non-specific symptoms and …

Correction To: Severity Of Depression, Anxious Distress And The Risk Of Type 2 Diabetes - A Population-Based Cohort Study In Sweden, Anna Deleskog, Rickard Ljung, Yvonne Forsell, Alicia Nevriana, Aysha Almas, Jette Möller

Section of Internal Medicine

Abstract

It was highlighted that the original article [1] contained an error in the flow chart in Fig. 1.