Medical Specialties Commons^™

A Model Of Cytomegalovirus Association With The Development Of Heart Graft Atherosclerosis, Evan Skowronski

Loma Linda University Electronic Theses, Dissertations & Projects

The development of graft atherosclerosis in heart transplant recipients has been associated with the development of post-transplant cytomegalovirus infection. The mechanism of this involvement, however, remains unclear. I undertook a study to determine the role of cytomegalovirus in the development of graft atherosclerosis. First, a rapid method of detecting cytomegalovirus based on capillary polymerase chain reaction and gel electrophoresis was employed to determine the presence of cytomegalovirus in a wide variety of clinical samples. Detection of cytomegalovirus is a lengthy procedure under normal conditions, and timely detection of cytomegalovirus in transplant recipients may allow intervention early enough to block the …

A Randomized Comparison Of Coronary-Stent Placement And Balloon Angioplasty In The Treatment Of Coronary Artery Disease. Stent Restenosis Study Investigators., David L. Fischman, Martin B. Leon, Donald S. Baim, Richard A. Schatz, Michael P. Savage, Ian Penn, Katherine Detre, Lisa Veltri, Donald Ricci, Masakiyo Nobuyoshi, Michael Cleman, Richard Heuser, David Almond, Paul S. Teirstein, R. David Fish, Antonio Colombo, Jeffrey Brinker, Jeffrey Moses, Alex Shaknovich, John Hirshfeld, Stephen Bailey, Stephen Ellis, Randal Rake, Sheldon Goldberg

Department of Medicine Faculty Papers

BACKGROUND: Coronary-stent placement is a new technique in which a balloon-expandable, stainless-steel, slotted tube is implanted at the site of a coronary stenosis. The purpose of this study was to compare the effects of stent placement and standard balloon angioplasty on angiographically detected restenosis and clinical outcomes.

METHODS: We randomly assigned 410 patients with symptomatic coronary disease to elective placement of a Palmaz-Schatz stent or to standard balloon angioplasty. Coronary angiography was performed at base line, immediately after the procedure, and six months later.

RESULTS: The patients who underwent stenting had a higher rate of procedural success than those who …

Instrumentation And Control For A Microprocessor-Based Coronary Perfusion System, Daniel L. Priester

Master's Theses (1922-2009) Access restricted to Marquette Campus

No abstract provided.

Clinical Features And Management Of Malignant Ascites, I Malik, S Abubakar, I Rizwana, F Alam, J Rizvi, A Khan

Section of Cardiology

Retrospective analysis of 45 patients (33 females, 12 males) with cytologically-proven malignant ascites is presented. Abdominal pain was the most frequent symptom (69%). Fiftythree percent cases had low serum albumin. Ascitic fluid was haemorrhagic or serosanguinous in 48% cases, in the rest it was clear or straw-coloured. Peritoneal effusion was exudative in 84% cases. Mean glucose content of ascitic fluid was 95 mg/dl and the mean white cell count of 919 cells/cmm. Vast majority (82%) of the cases had metastatic adenocarcinomas. Primary malignancy was mostly ovarian (47%) followed by non-Hodgkin's lymphoma (11%) and gall bladder carcinoma (9%). Primary site could …

The Report Of The American Heart Association Task Force On Strategies To Increase Federal Research Funding, Michael R. Rosen, Harold C. Strauss, Holly G. Atkinson, Alfred P. Fishman, Charles K. Francis, Arnold M. Katz, August M. Watanabe, Francois M. Abboud, Myron L. Weisfeldt, William F. Friedman, Bernadine P. Healy, Scott D. Ballin, Claudia Louis, Rodman D. Starke, Wallace G. Frasher

Publications and Research

No abstract provided.

In Vivo Demonstration Of Maturational Changes Of The Chronotropic Response To Α-Adrenergic Stimulation, Jorge Mccormack, Henry Gelband, Juan Villafañe, Hui Xu, Adrienne Stolfi, Arthur S. Pickoff

Medical Education Faculty Publications

In vitro studies suggest that neonates and adults may have different cardiac chronotropic responses to a-adrenergic stimulation. To investigate these differences in vivo, three groups of dogs were studied. Group I = 12 puppies, ages 3-7 days; group II = 12 puppies ages 8-15 days, and group III = seven adult dogs. Heart rate and blood pressure determinations were made in the control setting and then after combined β-adrenergic and parasympathetic blockade (propranolol 0.6 mg/kg and bilateral vagotomies). Alpha-stimulation was then achieved with phenylephrine given in doses of 0.5, 1.0, and 10.0 μg/kg/ min. A second, high dose of propranolol …

Atrioventricular Nodal Function In The Immature Canine Heart, Jorge Mccormack, Henry Gelband, Hui Xu, Juan Villafane, Adrienne Stolfi, Arthur S. Pickoff

Medical Education Faculty Publications

Previous studies have suggested that the atrioventricular nodal functional refractory period in the neonate is equal to or shorter than that of the ventricle, providing little or no protection to the ventricle against rapid atrial rates and allowing closely coupled atrial beats to fall within the ventricular vulnerable period. We evalu­ated atrioventricular node function in 21 mongrel neonatal puppies, 3-15 days old, and 15 adult dogs utilizing intracardiac His bundle recording and stimulation techniques. The mean atrioventricular nodal functional refractory period (173.1 ± 20.0 ms) exceeded both the ventricular effective refractory period (139.5 ± 14.3) and ventricular functional refractory period …

Ectopic Origin Of A Coronary Artery From The Aorta. Sudden Death In 3 Of 23 Patients., John Mahowald, L C. Blieden, J I. Coe, J E. Edwards

Articles

Ectopic origin of a coronary artery from the aorta is uncommon. In the last decade, its importance as a possible cause of sudden death has been documented. Initially, only the left coronary artery was implicated. Lately, the ectopically arising right coronary artery has also been shown to be involved in cases of sudden death. We reviewed the pathologic anatomy in 23 cases of ectopic origin of a coronary artery from the aorta. In three of these cases, death could be attributed to ectopic origin of a coronary artery. In one case the left coronary artery arose from the right aortic …

Digoxin-Quinidine Interaction In The Neonatal Dog, Arthur S. Pickoff, Adrienne Stolfi, Henry Gelband

Medical Education Faculty Publications

The effects of quinidine on steady state serum and tissue digoxin concentrations in the neonatal dog were studied. To determine the effects of quinidine on serum digoxin concentrations, two groups of neonates were evaluated: Group I (n = 11) was digitalized with 40 μg/kg body weight, intramuscularly, and placed on a 10 μg/kg per day maintenance dose; Group II (n = 7) was digitalized with 50 μg/kg per day, intraperitoneally, and placed on a 20 μg/kg per day maintenance dose. After 10 days of digoxin alone, quinidine was coadministered (30 mg/kg per day, intraperitoneally) for 7 days. Serum digoxin concentrations …

Serial Cardiovascular Adaptations During Pregnancy, Mark Vincent Hart

Dissertations and Theses

Maternal cardiovascular adaptations appear to be essential in order to supply extra circulation to both the developing fetus and maternal system during a successful pregnancy. Since inadequate cardiovascular adjustments may produce abortions or maternal morbidity, the characterization of maternal cardiovascular changes during pregnancy and the elaboration of the underlying mechanism for these changes are essential to the understanding of how the heart enlarges during pregnancy and what significance this enlargement might have. To provide needed information regarding this time course and extent of maternal cardiac enlargement and the hormonal and hemodynamic changes which may be responsible for these changes, the …

The Effect Of Cardiac Rehabilitation On Blood Lipids, Carol Lynn Bartholomew

MUSC Theses and Dissertations

The effect of cardiac rehabilitation on blood lipids was studied in a sample of seventeen male participants of the Greenville Hospital Center cardiac rehabilitation program. These subjects all suffered myocardial infarctions, but none had surgery to by-pass the obstructed coronary circulation. Paired values were obtained for triglyceride, serum cholesterol and HDL cholesterol before, and after the exercise program. The time span between the before-exercise and after-exercise values ranged from five to thirty-one weeks. The differences in the paired values were analyzed by the t-test. No significant decrease occurred in triglyceride or serum cholesterol. A significant increase occurred in HDL cholesterol.

J.T.: A Case Of Mitral Valve Prolapse, F. Matthew Mihelic

Faculty Publications

No abstract provided.

The Coronary Distribution Zone : Mathematical Modelling Of The Left Ventricular Epicardial Surface For Area Calculation, Three-Dimensional Rotaton And Display, S. Matts E. Sjölander

Loma Linda University Electronic Theses, Dissertations & Projects

A computer model of the left ventricular (LV) epicardial surface was developed from Jang’s truncated ellipsoidal model, which has a minor to major axis ratio of 6:10. The model was applied in calculating the area of a segment of the myocardium, jeopardized by an impending occlusion of its associated artery. The endangered segment of the LV muscle was also visualized in different projections by rotations in three space and graphical displays simulating the three dimensions.

The area formula for the surface of the ideal model , a truncated prolate spheroid, was derived and used in producing maps for manual calculations …

Ua35/11 Student Honors Bulletin, Vol. Iv, Wku Honors Program

WKU Administration Documents

The articles, all papers done for classes in the university honors program, are divided into three groups. The first group deals with science, especially the area of health care, one of the more practical applications of science in the modern age. The second group consists of three papers done for honor courses in which the major purpose was to expose the student to new areas of consciousness and have them respond orally and verbally to what they read, creative writing. The last group deals with the humanities, literature and religion, two of the more popular fields of the humanities today. …

The Degree And Time-Course Of Stress In The Patient Undergoing Cardiac Surgery, Hulda Esther Serra, Patricia Jo Yvonne Tygret

Loma Linda University Electronic Theses, Dissertations & Projects

An important nursing objective is to assist patients through stressful experiences. It has been assumed that cardiac surgery constitutes such a stress situation. For this reason, twenty-two patients undergoing cardiac surgery at Loma Linda University Hospital studied for the purpose of exploring the degree and time-course of were psychological stress.

The methodology consisted of administration of psychological tests before and after surgery; determination of urine catecholamines (UCA) before, during and after surgery; administration of a coping assessment tool before surgery, and a recall interview on the fifth day after surgery. The Multiple Affect Adjective Check List (MAACL)-Today form, and the …

Adherence Of Men With Myocardial Infarction To Prescribed Exercise, Marsha Schwartz

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to find out if men with myocardial infarction followed exercise prescribed by the physician. The reasons the patients did or did not follow the exercise prescription were investigated.

An interview guide was used to gather the data for this exploratory study. The questions on the interview guide were designed to obtain information to compare the former exercise pattern of the patient to exercise after infarction. Adherence to the exercise prescription was also determined by the exercise reported in the interview. Fifteen male subjects who had myocardial infarction were interviewed in the hospital and after …

Normal Development Of The Aortic Isthmus, Elizabeth Short

Yale Medicine Thesis Digital Library

The development of the aortic isthmus, that region of the arch of the aorta between the left subclavian artery and the attachment of the ligamentum arteriosum, has received little attention. While the developmental history of the ductus arteriosus and foramen ovale has been well documented, as have the cardiac malformations associated with failure to complete this developmental sequence, little work has been done to define the normal sequence of isthmus development in its transition to an adult configuration in the postnatal period. It has long been recognized that the cardiac malformation known as infantile or preductal coarctation of the aorta …

Neurological Complications Following Open Heart Surgery, Lavaun Ward Sutton

Loma Linda University Electronic Theses, Dissertations & Projects

The propose of this exploratory study was to gather data for analysis on possible predisposing or related factors in the development of neurological com plications following open heart surgery as well as to determine the scope and frequency of symptoms exhibited, indicative of cerebral damage. In addition, the researcher hoped to learn the outcome of these patients through information on the duration and resolution of symptoms, noting type and degree of residual problems as well as the incidence of mortality. A review of the literature provided background information for this study. This review indicated that although considerable attention has been …

Patients With Transistor Pacemakers : Their Problems In Adjusting To Daily Living, Miriam L. Moore

Loma Linda University Electronic Theses, Dissertations & Projects

It was the purpose of this study to gain greater insights into the problems and needs of patients with artificial pacemakers. The problem was to find out in what ways the pacemaker affected the patients' manner of living and what problems they had had in adjusting to a new way of life.

The method of the study was the descriptive survey; an interview guide was the tool. Seven patients who had been electronically paced for periods of four weeks to two and one half years were interviewed in their homes. The ages of the three men and four women ranged …

A Study Of Fever Differences Following Cardiac Surgery, Cleta Phyllis Lane

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to find out whether the temperature level following heart and great vessel surgery is greater following the use of the heart-lung machine than those following closed heart surgery or cardiac and great vessel surgery with the use of hypothermia.

The method used was the descriptive survey. Data were obtained from medical records in one selected hospital. The desired number of charts was 50 for each of the three categories. The categories were identified by groups as follows:

Group I: patients having had cardiac surgery by a closed heart technique. All of the patients in …

An Investigation Of A Possible Correlation Between Metallic Elements In Human Hair And Coronary Heart Disease, Lamar E. Bullock

Masters Theses

Introduction

In the academic year 1959-1960 the National Science Foundation supported an undergraduate research program at Western: Michigan University for the spectrographic analysis of human hair. This preliminary work concerned itself with determining the quantities of magnesium, iron, and calcium in human hair. The hair samples were taken from a supposedly normal cross section of people. This group consisted of 41 women and 52 men. The ages varied from 2 to 72. Most of the hair samples were collected from a local barber shop and beauty shop, although a small portion of the samples was collected from individuals. Information concerning …

Observations On The Formation And Dissolution Of Various Thrombi In Vivo By Direct Visualization, James D. Blanding Jr.

MUSC Theses and Dissertations

This investigation was an attempt to ascertain the effects of various physical factors on the formation and dissolution of various thrombi in the living animal. The main method consisted of crushing living veins in the mesenteries of the small intestines of frogs and rats and, with horizontally aimed microscopes: 1. Watching the formation of precipitous, sticky coatings on blood cells and blood cell masses. 2. Observing the building of intravascular material into easily detectable thrombi. 3. Studying the various phenomena occurring in the thrombi and in the adjacent blood streams. 4. Observing the eventual disintegration of most of the fresh …

Cardiac Arrhythmias Following Total Pneumonectomy, Arthur C. Miller

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

[No Advisor Signatures]

Intravenous Procaine During Thoracic Surgery, Forrest E. Leffingwell

Medical Arts and Sciences: A Scientific Journal of the College of Medical Evangelists

Surgery on the heart and paracardial structures or traction on the hilus of the lung may initiate serious arrhythmias which can result in death if not promptly controlled. Procedures involving the pericardium are particularly apt to be followed by severe derangements of rhythm. Thus anesthesiology is faced with another challenge.

It is now evident that the intravenous administration of procaine has become a valuable addition to the armamentarium of the anesthesiologist in his endeavor to preserve the integrity of the thread of life while the surgeon carries out his heroic assignment without restrictions.

A Study Of The Movements Of The Heart And Their Relationship To The Filling Of The Auricles., John H. Rompf

Electronic Theses and Dissertations

No abstract provided.