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Reproductive and Urinary Physiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Chemicals and Drugs (2)
- Bioethics and Medical Ethics (1)
- Clinical Epidemiology (1)
- Community Health and Preventive Medicine (1)
- Environmental Public Health (1)
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- Epidemiology (1)
- Health Services Administration (1)
- Health Services Research (1)
- Hormones, Hormone Substitutes, and Hormone Antagonists (1)
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- Maternal and Child Health (1)
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- ATP-sensitive potassium channel (1)
- Bioethics (1)
- Body mass index (1)
- Cohort (1)
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- Embryo (1)
- Endogenous cannabinoid anandamide (1)
- Genetic engineering (1)
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- Kidney neoplasms (1)
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- Stem cells - research - moral and ethical aspects (1)
- Xenopus oocytes (1)
- Publication
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Articles 1 - 3 of 3
Full-Text Articles in Reproductive and Urinary Physiology
A Cohort Study Of Reproductive And Hormonal Factors And Renal Cell Cancer Risk In Women, Gc Kabat, Stephanie A. Navarro Silvera, Ab Miller, Te Rohan
A Cohort Study Of Reproductive And Hormonal Factors And Renal Cell Cancer Risk In Women, Gc Kabat, Stephanie A. Navarro Silvera, Ab Miller, Te Rohan
Department of Public Health Scholarship and Creative Works
We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had X5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR 1⁄4 2.41, 95% CI 1⁄4 1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were …
Update - January 2007, Loma Linda University Center For Christian Bioethics
Update - January 2007, Loma Linda University Center For Christian Bioethics
Update
In this issue:
-- Stem Cells, Embryos, and Ethics: Is There a Way Forward?
-- Editorial
-- 2006 Contributor's Convocation "Present Day Health Care: Collaborate or Close the Door"
The Endogenous Cannabinoid Anandamide Inhibits Cromakalim-Activated K+ Currents In Follicle-Enclosed Xenopus Oocytes, Murat Oz, Keun-Hang Susan Yang, Meral Dinc, Toni S. Shippenberg
The Endogenous Cannabinoid Anandamide Inhibits Cromakalim-Activated K+ Currents In Follicle-Enclosed Xenopus Oocytes, Murat Oz, Keun-Hang Susan Yang, Meral Dinc, Toni S. Shippenberg
Mathematics, Physics, and Computer Science Faculty Articles and Research
The effect of the endogenous cannabinoid anandamide on K+ currents activated by the ATP-sensitive potassium (KATP) channel opener cromakalim was investigated in follicle-enclosed Xenopus oocytes using the two-electrode voltage-clamp technique. Anandamide (1–90 μM) reversibly inhibited cromakalim-induced K+ currents, with an IC50 value of 8.1 ± 2 μM. Inhibition was noncompetitive and independent of membrane potential. Coapplication of anandamide with the cannabinoid type 1 (CB1) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboximide hydrochloride (SR 141716A) (1 μM), the CB2 receptor antagonist N-[(1S)endo-1,3,3-trimethyl bicyclo heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528) (1 μM), or pertussis toxin (5 μg/ml) did not alter the inhibitory effect of anandamide, suggesting that known cannabinoid receptors …