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Articles 1 - 6 of 6
Full-Text Articles in Other Medical Sciences
Alternative Therapies To Treat Cardiovascular Disease, Brent D. Jergens
Alternative Therapies To Treat Cardiovascular Disease, Brent D. Jergens
Honors Capstones
Capstone submitted as a graduation requirement for the BSU Honors Program.
The Cell Surface Receptor Slam Controls T Cell And Macrophage Functions, Ninghai Wang, Abhay Satoskar, William Faubion, Susumu Okamoto, Stefan Feske, Charles A. Gullo Phd, Kareem Clarke, Miriam Rodriguez Sosa, Arlene H. Sharpe, Cox Terhorst
The Cell Surface Receptor Slam Controls T Cell And Macrophage Functions, Ninghai Wang, Abhay Satoskar, William Faubion, Susumu Okamoto, Stefan Feske, Charles A. Gullo Phd, Kareem Clarke, Miriam Rodriguez Sosa, Arlene H. Sharpe, Cox Terhorst
Biochemistry and Microbiology
Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus. Here we show that T cell receptor–induced interleukin (IL)-4 secretion by SLAM−/− CD4+ cells is down-regulated, whereas interferon γ production by CD4+ T cells is only slightly up-regulated. Although SLAM controls production of IL-12, tumor necrosis factor, and nitric oxide in response to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG. Thus, SLAM acts as a coreceptor …
Trials, Tribulations, And Trends In Tumor Modeling In Mice, Joann C. L. Schuh
Trials, Tribulations, And Trends In Tumor Modeling In Mice, Joann C. L. Schuh
Toxicology and Animal Models in Research Collection
Selection of mouse models of cancer is often based simply on availability of a mouse strain and a known compatible tumor. Frequently this results in use of tumor models long on history but short on homology and quality control. Other factors including genetics, sex, immunological status, method and site of tumor implantation, technical competence, biological activity of the tumor, protocol sequence and timing, and selection of endpoints interact to produce outcomes in tumor models. Common reliance on survival and tumor burden data in a single mouse model often skews expectations towards high remission and cure rates; a finding seldom duplicated …
Trials, Tribulations, And Trends In Tumor Modeling In Mice, Joann C. L. Schuh
Trials, Tribulations, And Trends In Tumor Modeling In Mice, Joann C. L. Schuh
Biomedicine and Animal Models in Research Collection
Selection of mouse models of cancer is often based simply on availability of a mouse strain and a known compatible tumor. Frequently this results in use of tumor models long on history but short on homology and quality control. Other factors including genetics, sex, immunological status, method and site of tumor implantation, technical competence, biological activity of the tumor, protocol sequence and timing, and selection of endpoints interact to produce outcomes in tumor models. Common reliance on survival and tumor burden data in a single mouse model often skews expectations towards high remission and cure rates; a finding seldom duplicated …
Renal Basolateral Transport Of Glucuronides And Other Organic Anions In Rat In Vitro Models, Sarah L. Miles
Renal Basolateral Transport Of Glucuronides And Other Organic Anions In Rat In Vitro Models, Sarah L. Miles
Theses, Dissertations and Capstones
Glucuronidation is a common Phase II biotransformation reaction that increases the hydrophilicity, and thus elimination, of toxins, xenobiotics, and endogenous compounds. Previous studies suggest that the kidney can secrete glucuronide conjugates, but the renal transport mechanisms for glucuronide secretion have not been determined. Based on the chemical nature of glucuronide metabolites, it is hypothesized that organic anion transporter (OAT) proteins along the basolateral membrane of the renal proximal tubule promote renal accumulation of glucuronide conjugates. The purpose of this study was to develop a rat renal proximal tubule model which demonstrates OAT activity and by which the contribution of OAT …
Multi-Channel Fetal Magnetocardiographic Signal Seperation For Analysis Of Heart Rate Variability, Joshua Quaid Campbell
Multi-Channel Fetal Magnetocardiographic Signal Seperation For Analysis Of Heart Rate Variability, Joshua Quaid Campbell
Theses and Dissertations
Objective: The objectives were to implement signal-processing techniques to separate the fetal magnetocardiogram (FMCG), as collected by SQUID (Superconducting QUantum Interference Device) gradiometers, from mixtures of maternal and fetal biomagnetic signals recorded during the antepartum period and to develop a database of normal FMCG values of the fetal cardiac time intervals and heart rate variability measures. Materials and Methods: The research was performed in three phases: 1) Independent component analysis (ICA), nonlinear filtering techniques, and orthogonal projection methods were optimized enabling the FMCG to be processed using traditional signal analysis techniques; 2) The cardiac time intervals and heart rate variability …