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2005

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Articles 1 - 19 of 19

Full-Text Articles in Neurosciences

The Cerebral Response During Subjective Choice With And Without Self-Reference, Sterling C. Johnson, Taylor W. Schmitz, Tisha N. Kawahara-Baccus, Howard A. Rowley, Andrew L. Alexander, Jonghoon Lee, Richard J. Davidson Dec 2005

The Cerebral Response During Subjective Choice With And Without Self-Reference, Sterling C. Johnson, Taylor W. Schmitz, Tisha N. Kawahara-Baccus, Howard A. Rowley, Andrew L. Alexander, Jonghoon Lee, Richard J. Davidson

Brain and Mind Institute Researchers' Publications

The anterior medial prefrontal (AMPFC) and retrosplenial (RSC) cortices are active during self-referential decision-making tasks such as when participants appraise traits and abilities, or current affect. Other appraisal tasks requiring an evaluative decision or mental representation, such as theory of mind and perspective-taking tasks, also involve these regions. In many instances, these types of decisions involve a subjective opinion or preference, but also a degree of ambiguity in the decision, rather than a strictly veridical response. However, this ambiguity is generally not controlled for in studies that examine self-referential decision-making. In this functional magnetic resonance imaging experiment with 17 healthy …

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Assessment Of Executive Function In Preschool-Aged Children, Peter K. Isquith, Jennifer S. Crawford, Kimberly A. Espy, Gerard G. Gioia Nov 2005

Assessment Of Executive Function In Preschool-Aged Children, Peter K. Isquith, Jennifer S. Crawford, Kimberly A. Espy, Gerard G. Gioia

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Assessment of the overarching self-regulatory mechanisms, or executive functions, in any age group is challenging, in part due to the complexity of this domain, in part due to their dynamic essence, and in part due to the inextricable links between these central processes and the associated domain-specific processes, such as language, motor function, and attention, over which they preside. While much progress has been made in clinical assessment approaches for measuring executive functions in adults and to some extent in adolescents and school-aged children, the toolkit for the preschool evaluator remains sparse. The past decade, however, has seen a substantial …

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Inhibitory Processes In Young Children And Individual Variation In Short-Term Memory, Kimberly A. Espy, Rebecca Bull Nov 2005

Inhibitory Processes In Young Children And Individual Variation In Short-Term Memory, Kimberly A. Espy, Rebecca Bull

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

A precise definition of executive control remains elusive, related in part to the variations among executive tasks in the nature of the task demands, which complicate the identification of test-specific versus construct-specific performance. In this study, tasks were chosen that varied in the nature of the stimulus (verbal, nonverbal), response (naming, somatic motor), conflict type (proactive interference, distraction), and inhibitory process (attention control, response suppression) required. Then performance differences were examined in 184 young children (age range = 3 years 6 months to 6 years 1 month), comparing those with high (5 or more digits) and low (3 or fewer …

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Charge Screening By Internal Ph And Polyvalent Cations As A Mechanism For Activation, Inhibition, And Rundown Of Trpm7/Mic Channels, J. Ashot Kozak, Masayuki Matsushita, Angus C. Nairn, Michael D. Cahalan Nov 2005

Charge Screening By Internal Ph And Polyvalent Cations As A Mechanism For Activation, Inhibition, And Rundown Of Trpm7/Mic Channels, J. Ashot Kozak, Masayuki Matsushita, Angus C. Nairn, Michael D. Cahalan

Neuroscience, Cell Biology & Physiology Faculty Publications

The Mg2+-inhibited cation (MIC) current, believed to represent activity of TRPM7 channels, is found in lymphocytes and mast cells, cardiac and smooth muscle, and several other eukaryotic cell types. MIC current is activated during whole-cell dialysis with divalent-free internal solutions. Millimolar concentrations of intracellular Mg2+ (or other divalent metal cations) inhibit the channels in a voltage-independent manner. The nature of divalent inhibition and the mechanism of channel activation in an intact cell remain unknown. We show that the polyamines (spermine, spermidine, and putrescine) inhibit the MIC current, also in a voltage-independent manner, with a potency that parallels …

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Studies On The Basis For The Properties Of Fibrin Produced From Fibrinogen-Containing Γ′ Chains, Kevin R. Siebenlist, Michael W. Mosesson, Irene Hernandez, Leslie A. Bush, Enrico Di Cera, John R. Shainoff, James P. Diorio, Laurie Stajanovic Oct 2005

Studies On The Basis For The Properties Of Fibrin Produced From Fibrinogen-Containing Γ′ Chains, Kevin R. Siebenlist, Michael W. Mosesson, Irene Hernandez, Leslie A. Bush, Enrico Di Cera, John R. Shainoff, James P. Diorio, Laurie Stajanovic

Biomedical Sciences Faculty Research and Publications

Human fibrinogen 1 is homodimeric with respect to its γ chains (`γA-γA'), whereas fibrinogen 2 molecules each contain one γA (γA1-411V) and one γ' chain, which differ by containing a unique C-terminal sequence from γ'408 to 427L that binds thrombin and factor XIII. We investigated the structural and functional features of these fibrins and made several observations. First, thrombin-treated fibrinogen 2 produced finer, more branched clot networks than did fibrin 1. These known differences in network structure were attributable to delayed release of fibrinopeptide (FP) A from fibrinogen 2 by thrombin, which in …

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Do Inhalation General Anesthetic Drugs Induce The Neuronal Release Of Endogenous Opioid Peptides?, Raymond M. Quock, Linda K. Vaughn Oct 2005

Do Inhalation General Anesthetic Drugs Induce The Neuronal Release Of Endogenous Opioid Peptides?, Raymond M. Quock, Linda K. Vaughn

Biomedical Sciences Faculty Research and Publications

The antagonism of some effects of inhalation general anesthetic agents by naloxone suggests that there may be an opioid component to anesthetic action. There is evidence that this opioid action component is due to neuronal release of endogenous opioid peptides. The strongest evidence is provided by studies that monitor changes in the concentration of opioid peptides in the perfused brain following inhalation of the anesthetic. Indirect or circumstantial evidence also comes from studies of anesthetic effects on regional brain levels of opioid peptides, antagonism of selected anesthetic effects by antisera to opioid peptides and anesthetic-induced changes radioligand binding to opioid …

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Resting Potential–Dependent Regulation Of The Voltage Sensitivity Of Sodium Channel Gating In Rat Skeletal Muscle In Vivo, Gregory N. Filatov, Martin J. Pinter, Mark M. Rich Aug 2005

Resting Potential–Dependent Regulation Of The Voltage Sensitivity Of Sodium Channel Gating In Rat Skeletal Muscle In Vivo, Gregory N. Filatov, Martin J. Pinter, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

Normal muscle has a resting potential of −85 mV, but in a number of situations there is depolarization of the resting potential that alters excitability. To better understand the effect of resting potential on muscle excitability we attempted to accurately simulate excitability at both normal and depolarized resting potentials. To accurately simulate excitability we found that it was necessary to include a resting potential–dependent shift in the voltage dependence of sodium channel activation and fast inactivation. We recorded sodium currents from muscle fibers in vivo and found that prolonged changes in holding potential cause shifts in the voltage dependence of …

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The Neural Mechanisms Of Speech Comprehension: Fmri Studies Of Semantic Ambiguity, Jennifer M Rodd, Matthew H Davis, Ingrid Johnsrude Aug 2005

The Neural Mechanisms Of Speech Comprehension: Fmri Studies Of Semantic Ambiguity, Jennifer M Rodd, Matthew H Davis, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

A number of regions of the temporal and frontal lobes are known to be important for spoken language comprehension, yet we do not have a clear understanding of their functional role(s). In particular, there is considerable disagreement about which brain regions are involved in the semantic aspects of comprehension. Two functional magnetic resonance studies use the phenomenon of semantic ambiguity to identify regions within the fronto-temporal language network that subserve the semantic aspects of spoken language comprehension. Volunteers heard sentences containing ambiguous words (e.g. 'the shell was fired towards the tank') and well-matched low-ambiguity sentences (e.g. 'her secrets were written …

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Anticuerpos Contra El Virus De La Estomatitis Vesicularen Sajinos (Tayassu Tajacu) De Zoocriaderos De Iquitos Y Pucallpa, Aldo D. Wilson, Mariluz Araínga, Hugo Galvez C., Alberto Manchego S., Hermelinda G. Rivera Jul 2005

Anticuerpos Contra El Virus De La Estomatitis Vesicularen Sajinos (Tayassu Tajacu) De Zoocriaderos De Iquitos Y Pucallpa, Aldo D. Wilson, Mariluz Araínga, Hugo Galvez C., Alberto Manchego S., Hermelinda G. Rivera

Journal Articles: Pharmacology & Experimental Neuroscience

The objetive of this study was to detect antibodies against vesicular stomatitis virus (VSV) collared peccaries in (Tayassu tajacu) from farms of Iquitos and Pucallpa, Peru. Blood samples were collected in animals olders than 6 months of age (pregnant females were not included) from a farm in Iquitos (n = 21) and from four farms in Pucallpa (n = 47), for detection of antibodies against Indiana 1 and New Jersey serotype of VSV by viral neutralization test. No specific antibodies against both serotypes of VSV were detected, indicating that the peccaries were not exposed to VSV, and suggesting absence of …

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A Critical Role For Kalirin In Ngf Signaling Through Trka, Kausik Chakrabarti, Rong Lin, Noraisha I. Schiller, Yanping Wang, David Koubi, Ying-Xin Fan, Brian B. Rudkin, Gibbes R. Johnson, Martin R. Schiller Jun 2005

A Critical Role For Kalirin In Ngf Signaling Through Trka, Kausik Chakrabarti, Rong Lin, Noraisha I. Schiller, Yanping Wang, David Koubi, Ying-Xin Fan, Brian B. Rudkin, Gibbes R. Johnson, Martin R. Schiller

Life Sciences Faculty Research

Kalirin is a multidomain guanine nucleotide exchange factor (GEF) that activates Rho proteins, inducing cytoskeletal rearrangement in neurons. Although much is known about the effects of Kalirin on Rho GTPases and neuronal morphology, little is known about the association of Kalirin with the receptor/signaling systems that affect neuronal morphology. Our experiments demonstrate that Kalirin binds to and colocalizes with the TrkA neurotrophin receptor in neurons. In PC12 cells, inhibition of Kalirin expression using antisense RNA decreased nerve growth factor (NGF)-induced TrkA autophosphorylation and process extension. Kalirin overexpression potentiated neurotrophin-stimulated TrkA autophosphorylation and neurite outgrowth in PC12 cells at a low …

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A New Interpretation Of The Drug Levodopa In The Treatment Of Parkinson's Disease, Joanne T. Vannah Jun 2005

A New Interpretation Of The Drug Levodopa In The Treatment Of Parkinson's Disease, Joanne T. Vannah

Graduate Masters Theses

An argument for levodopa induced dyskinesias (LID) as an expression of long term potentiation (LTP) in the striatum is presented. Normally, with an intact nigrostriatal dopamine (DA) input, long term depression (LTD) is expressed in the striatum, however, striatal LTD is lost following DA denervation and chronic levodopa treatment. It is possible that these changes in synaptic efficacy are due to two other chemical modulators, achetylcholine (ACh) and glutamate, which in turn leads to the induction of striatal LTP. ACh and glutamate may produce these changes in motor behavior by affecting the striosomal pathway in addition to their effect on …

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Stim1, An Essential And Conserved Component Of Store-Operated Ca2+ Channel Function, Jack Roos, Paul J. Digregorio, Andriy V. Yeromin, Kari Ohlsen, Maria I. Lioudyno, Shenyuan L. Zhang, Olga Safrina, J. Ashot Kozak, Steven L. Wagner, Michael D. Cahalan, Gönül Veliçelebi, Kenneth A. Stauderman May 2005

Stim1, An Essential And Conserved Component Of Store-Operated Ca2+ Channel Function, Jack Roos, Paul J. Digregorio, Andriy V. Yeromin, Kari Ohlsen, Maria I. Lioudyno, Shenyuan L. Zhang, Olga Safrina, J. Ashot Kozak, Steven L. Wagner, Michael D. Cahalan, Gönül Veliçelebi, Kenneth A. Stauderman

Neuroscience, Cell Biology & Physiology Faculty Publications

Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interference (RNAi)-based screen to identify genes that alter thapsigargin (TG)-dependent Ca2+ entry, we discovered a required and conserved role of Stim in SOC influx. RNAi-mediated knockdown of Stim in Drosophila S2 cells significantly reduced TG-dependent Ca2+ entry. Patch-clamp recording revealed nearly complete suppression of the Drosophila Ca2+ release-activated Ca2+(CRAC) current that has biophysical characteristics similar to CRAC current in human T cells. Similarly, knockdown of the human homologue STIM1 significantly reduced CRAC channel activity …

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A Developmental Switch In The Response Of Drg Neurons To Ets Transcription Factor Signaling, Simon Hippenmeyer, Eline Vrieseling, Markus Sigrist, Thomas Portmann, Celia Laengle, David R. Ladle, Silvia Arber May 2005

A Developmental Switch In The Response Of Drg Neurons To Ets Transcription Factor Signaling, Simon Hippenmeyer, Eline Vrieseling, Markus Sigrist, Thomas Portmann, Celia Laengle, David R. Ladle, Silvia Arber

Neuroscience, Cell Biology & Physiology Faculty Publications

Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal …

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Glutamate Receptors In Perirhinal Cortex Mediate Encoding, Retrieval, And Consolidation Of Object Recognition Memory., Boyer D Winters, Timothy J Bussey Apr 2005

Glutamate Receptors In Perirhinal Cortex Mediate Encoding, Retrieval, And Consolidation Of Object Recognition Memory., Boyer D Winters, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

Object recognition is consistently impaired in human amnesia and animal models thereof. Results from subjects with permanent brain damage have revealed the importance of the perirhinal cortex to object recognition memory. Here, we report evidence from rats for interdependent but distinct stages in object recognition memory (encoding, retrieval, and consolidation), which require glutamate receptor activity within perirhinal cortex. Transient blockade of AMPA receptor-mediated synaptic transmission within perirhinal cortex disrupted encoding for short- and long-term memory as well as retrieval and consolidation. In contrast, transient NMDA receptor blockade during encoding affected only long-term object recognition memory; NMDA receptor activity was also …

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Learning To Like: A Role For Human Orbitofrontal Cortex In Conditioned Reward, Sylvia M L Cox, Alexandre Andrade, Ingrid Johnsrude Mar 2005

Learning To Like: A Role For Human Orbitofrontal Cortex In Conditioned Reward, Sylvia M L Cox, Alexandre Andrade, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

A great deal of human behavior and motivation is based on the intrinsic emotional significance of rewarding or aversive events, as well as on the associations formed between such emotional events and concurrent environmental stimuli. Recent functional neuroimaging studies have implicated the ventral striatum, orbitofrontal cortex (OFC), and amygdala in the representation of reward values and/or in the anticipation of rewarding events. Here, we use functional magnetic resonance imaging to compare brain activation during the presentation of reward with that during presentation of (conditioned) stimuli that have been paired previously with reward. Specifically, we aimed to investigate conditioned reward in …

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A Contralateral Preference In The Lateral Occipital Area: Sensory And Attentional Mechanisms., Matthias Niemeier, Herbert C Goltz, Anil Kuchinad, Douglas B Tweed, Tutis Vilis Mar 2005

A Contralateral Preference In The Lateral Occipital Area: Sensory And Attentional Mechanisms., Matthias Niemeier, Herbert C Goltz, Anil Kuchinad, Douglas B Tweed, Tutis Vilis

Brain and Mind Institute Researchers' Publications

Here we examined the level of the lateral occipital (LO) area within the processing stream of the ventral visual cortex. An important determinant of an area's level of processing is whether it codes visual elements on both sides of the visual field, as do higher visual areas, or prefers those in the contralateral visual field, as do early visual areas. The former would suggest that LO, on one side, combines bilateral visual elements into a whole, while the latter suggests that it codes only the parts of forms. We showed that LO has a relative preference for visual objects in …

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Transient Inactivation Of Perirhinal Cortex Disrupts Encoding, Retrieval, And Consolidation Of Object Recognition Memory., Boyer D Winters, Timothy J Bussey Jan 2005

Transient Inactivation Of Perirhinal Cortex Disrupts Encoding, Retrieval, And Consolidation Of Object Recognition Memory., Boyer D Winters, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

Damage to perirhinal cortex (PRh) impairs object recognition memory in humans, monkeys, and rats when tested in tasks such as delayed nonmatching to sample, visual paired comparison, and its rodent analog, the spontaneous object recognition task. In the present study, we have capitalized on the discrete one-trial nature of the spontaneous object recognition task to investigate the role of PRh in several distinct stages of object recognition memory. In a series of experiments, transient inactivation of PRh was accomplished with bilateral infusions of lidocaine directly into PRh immediately before the sample phase (encoding), immediately before the choice phase (retrieval), or …

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Measuring Shared Information And Coordinated Activity In Neuronal Networks, K L. Klinkner, C R. Shalizi, Marcelo Camperi Jan 2005

Measuring Shared Information And Coordinated Activity In Neuronal Networks, K L. Klinkner, C R. Shalizi, Marcelo Camperi

Physics and Astronomy

Most nervous systems encode information about stimuli in the respond- ing activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials. Since multiple electrode recordings are now a standard tool in neuroscience research, it is important to have a measure of such network-wide behav- ioral coordination and information sharing, applicable to multiple neural spike train data. We propose a new statistic, informational coherence , which measures how much better one unit can be predicted by knowing the dynamical state of another. We argue informational coherence is a measure of association and shared information …

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Dinámica De Seroconversión En Hembras Bovinas Post Eliminación De Animales Portadores Del Virus De La Diarrea Viral Bovina., Jayashi Cesar F., Gavidia Cesar C., Mariluz Araínga, Alberto Manchego, Hermelinda G. Rivera Jan 2005

Dinámica De Seroconversión En Hembras Bovinas Post Eliminación De Animales Portadores Del Virus De La Diarrea Viral Bovina., Jayashi Cesar F., Gavidia Cesar C., Mariluz Araínga, Alberto Manchego, Hermelinda G. Rivera

Journal Articles: Pharmacology & Experimental Neuroscience

A study was conducted to determine the effect of culling BVDV carrier animals on the seroconversion against BVDV in the new generation of heifers from a dairy herd located in Arequipa, Peru. Blood samples were collected from 6-12 month old females in four sampling periods: January (n = 73), June (n = 48), October 2003 (n = 48), and January 2004 (n = 35) to evaluate their serological against BVDV status and to screen for carrier animals using the virus neutralization and antigen-capture ELISA tests, respectively. The prevalence of BVDV was 80.8 ± 9.0, 56.3 ± 14.0, 50.0 ± 14.2 …

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