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2002

Articles 1 - 9 of 9

Full-Text Articles in Neurosciences

Executive Functions In Preschool Children Born Preterm: Application Of Cognitive Neuroscience Paradigms, K. A. Espy, M. M. Stalets, M. D. Mcdiarmid, T. E. Senn, M. F. Cwik, A. Hamby Nov 2002

Executive Functions In Preschool Children Born Preterm: Application Of Cognitive Neuroscience Paradigms, K. A. Espy, M. M. Stalets, M. D. Mcdiarmid, T. E. Senn, M. F. Cwik, A. Hamby

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Although children born preterm are at risk for neuropsychological impairments at school age and adolescence, including difficulties with visual motor integration, spatial/constructional skills, attention, arithmetic, and nonverbal executive functions, specific neuropsychological outcome has not been investigated adequately in preschoolers. Application of cognitive neuroscience tasks offers the opportunity to characterize early executive functions in young children born preterm. In a preliminary sample of 29 preschool children born preterm (M birth gestational age=32.4 weeks), executive function outcome was compared to that of fullterm controls by contrasting performance on two prototypic delayed-response-type paradigms, Delayed Alternation and Spatial Reversal. Preschoolers born preterm correctly retrieved …

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Individual Differences In The Development Of Executive Function In Children: Lessons From The Delayed Response And A-Not-B Tasks, K. A. Espy, P. M. Kaufmann Nov 2002

Individual Differences In The Development Of Executive Function In Children: Lessons From The Delayed Response And A-Not-B Tasks, K. A. Espy, P. M. Kaufmann

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

An explosion of research activity in the area of attention, memory, and executive function has been noted since the mid-1980s (Lyon & Krasnegor, 1996). The bulk of this activity, however, has focused on the examination of group differences in executive skills, with less attention devoted to the manner by which individual children differ in executive skills from their peers. This chapter explores individual differences from a developmental perspective, that is, by returning to the emergence of basic executive functions and tracing the subsequent manifestations by examining the individual patterns of change. Therefore, it first reviews the history of executive function …

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Confirmatory Factor Analysis Of The Behavior Rating Inventory Of Executive Function (Brief) In A Clinical Sample, G. G. Gioia, P. K. Isquith, P. D. Retzlaff, K. A. Espy Nov 2002

Confirmatory Factor Analysis Of The Behavior Rating Inventory Of Executive Function (Brief) In A Clinical Sample, G. G. Gioia, P. K. Isquith, P. D. Retzlaff, K. A. Espy

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

Evidence for the validity of the Behavior Rating Inventory of Executive Function (BRIEF; Gioia, Isquith, Guy, & Kenworthy, 2000) based on internal structure was examined in a sample of children with mixed clinical diagnoses via maximum likelihood confirmatory factor analysis. Four alternative factor models of children's executive function, based on current theories that posit a unidimensional versus fractionated model (Rabbitt, 1997; Shallice & Burgess, 1991), using the revised 9-scale BRIEF configuration that separates two components of the Monitor scale, were examined for model fit. A 3-factor structure best modeled the data when compared directly with 1-, 2-, and 4-factor models. …

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"Getting Into The Mouths" Of Preschoolers: A Method For Obtaining Buccal Samples For Later Genotyping, K. A. Espy, A. F. Hamby Nov 2002

"Getting Into The Mouths" Of Preschoolers: A Method For Obtaining Buccal Samples For Later Genotyping, K. A. Espy, A. F. Hamby

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

A new procedure is described by which to obtain buccal samples from preschool children for research investigations that include genotyping. Called the "Lollipop Tasting Game", the procedure involves three mason jars which were filled about halfway with water. Granulated sugar was added to each jar to make a noticeably sweet solution. Red food coloring was added to the first jar, a small bit of reconstituted lemon juice and yellow food coloring were added to the second jar, and finally, a bit of vanilla and blue food coloring were added to the last jar. The examiner dips cotton swabs in the …

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Informed Consent For Alzheimer's Disease Clinical Trials: A Survey Of Clinical Investigators, Peter J. Whitehouse Sep 2002

Informed Consent For Alzheimer's Disease Clinical Trials: A Survey Of Clinical Investigators, Peter J. Whitehouse

Faculty Scholarship

No abstract provided.

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Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths Via Rhog-Mediated Mechanisms, Victor May, Martin R. Schiller, Betty A. Eipper, Richard E. Mains Aug 2002

Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths Via Rhog-Mediated Mechanisms, Victor May, Martin R. Schiller, Betty A. Eipper, Richard E. Mains

Life Sciences Faculty Research

The large multidomain Kalirin and Trio proteins containing dual Rho GTPase guanine nucleotide exchange factor (GEF) domains have been implicated in the regulation of neuronal fiber extension and pathfinding during evelopment. In mammals, Kalirin is expressed predominantly in the nervous system, whereas Trio, broadly expressed throughout the body, is expressed at a lower level in the nervous system. To evaluate the role of Kalirin in fiber initiation and outgrowth, we microinjected cultured sympathetic neurons with vectors encoding Kalirin or with Kalirin antisense oligonucleotides, and we assessed neuronal fiber growth in a serum-free, satellite cell-free environment. Kalirin antisense oligonucleotides blocked the …

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Distinct Properties Of Crac And Mic Channels In Rbl Cells, J. Ashot Kozak, Hubert H. Kerschbaum, Michael D. Cahalan Aug 2002

Distinct Properties Of Crac And Mic Channels In Rbl Cells, J. Ashot Kozak, Hubert H. Kerschbaum, Michael D. Cahalan

Neuroscience, Cell Biology & Physiology Faculty Publications

In rat basophilic leukemia (RBL) cells and Jurkat T cells, Ca2+ release–activated Ca2+ (CRAC) channels open in response to passive Ca2+ store depletion. Inwardly rectifying CRAC channels admit monovalent cations when external divalent ions are removed. Removal of internal Mg2+ exposes an outwardly rectifying current (Mg2+-inhibited cation [MIC]) that also admits monovalent cations when external divalent ions are removed. Here we demonstrate that CRAC and MIC currents are separable by ion selectivity and rectification properties: by kinetics of activation and susceptibility to run-down and by pharmacological sensitivity to external Mg2+, spermine, and …

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Spectral And Temporal Processing In Human Auditory Cortex, Deborah A Hall, Ingrid Johnsrude, Mark P Haggard, Alan R Palmer, Michael A Akeroyd, A Quentin Summerfield Feb 2002

Spectral And Temporal Processing In Human Auditory Cortex, Deborah A Hall, Ingrid Johnsrude, Mark P Haggard, Alan R Palmer, Michael A Akeroyd, A Quentin Summerfield

Brain and Mind Institute Researchers' Publications

Hierarchical processing suggests that spectrally and temporally complex stimuli will evoke more activation than do simple stimuli, particularly in non-primary auditory fields. This hypothesis was tested using two tones, a single frequency tone and a harmonic tone, that were either static or frequency modulated to create four stimuli. We interpret the location of differences in activation by drawing comparisons between fMRI and human cytoarchitectonic data, reported in the same brain space. Harmonic tones produced more activation than single tones in right Heschl's gyrus (HG) and bilaterally in the lateral supratemporal plane (STP). Activation was also greater to frequency-modulated tones than …

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Erratum: A Comparison Between Walsh And Autoregressive Derived Parameters Of Heart Rate Variability Spectra In Normal Subjects And Diabetics Jan 2002

Erratum: A Comparison Between Walsh And Autoregressive Derived Parameters Of Heart Rate Variability Spectra In Normal Subjects And Diabetics

Neurosciences

No abstract provided.

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