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Progressive Cross-Linking Of Fibrin Gamma Chains Increases Resistance To Fibrinolysis, Kevin R. Siebenlist, Michael W. Mosesson

Biomedical Sciences Faculty Research and Publications

In the presence of plasma transglutaminase (factor XIIIa) fibrin first undergoes intermolecular covalent cross-linking between its gamma chains to create gamma dimers followed by slower cross-linking among its alpha chains to form alpha polymers. Progressive cross-linking of gamma chain dimers occurs at the slowest rate, resulting in gamma trimers and gamma tetramers (“gamma multimers”). Most studies indicate that cross-linked fibrin clots become resistant to fibrinolysis, but the basis for this event is not clear. In this study, we explored the role of gamma chain multimerization compared with alpha polymerization as causal factors in time-dependent development of resistance to fibrinolysis. Fibrin …

Effects Of Natural Sequence Variation On Recognition By Monoclonal Antibodies Neutralize Simian Immunodeficiency Virus Infectivity, Weon Sang Choi, Catherine Collignon, Clotilde Thiriart, Dawn P. Wooley, E. J. Scott, Karen A. Kent, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

The determinants of immune recognition by five monoclonal antibodies (KK5, KK9, KK17, Senv7.1, and Senv101.1) that neutralize simian immunodeficiency virus infectivity were analyzed. These five neutralizing monoclonal antibodies were generated to native SIVmac251 envelope glycoprotein expressed by a vaccinia virus recombinant vector. All five recognize conformational or discontinuous epitopes and require native antigen for optimal recognition. These monoclonal antibodies also recognize SIVmac239 gp120, but they do not recognize gp120 of two natural variants of SIVmac239, 1-12 and 8-22, which evolved during the course of persistent infection in vivo (D.P.W. Burns and R.C. Desrosiers, J. Virol. 65:1843-1854, 1991). Recombinant viruses which …

Increased Brain Aneurysm Wall Strain: A Further Hazard For Rupture, George M. Austin, Wouter Schievink, Delbert Dickson, Stephanie Richardson, Emily Hanford

The Dr. George M. Austin Neurology Research Collection

Increased Aneurysm Wall Strain: A Potential for Rupture. George M. Austin, M.D., Wouter Schievink, M.D., Delbert Dickson, M.D., Stephanie Richardson, B.S. August 12,1994. Portland, Oregon, 3 pg. See also previously presented version in additional files.

High Rates Of Frameshift Mutations Within Homo-Oligomeric Runs During A Single Cycle Of Retroviral Replication, Dawn P. Wooley, H. M. Temin

Neuroscience, Cell Biology & Physiology Faculty Publications

Homo-oligomeric runs were inserted into a spleen necrosis virus-based retrovirus vector to determine the nature and rate of mutations within runs of 10 to 12 identical nucleotides during a single replication cycle. Clones of helper cells containing integrated copies of retroviral vectors were used to produce virus for infection of target (nonhelper) cells. Proviral sequences from target cell clones were compared with proviral sequences from helper cell clones to study mutations that occurred during a single cycle of replication. In addition to the internal region spanning the homo-oligomeric inserts, a naturally occurring run of 10 T's in the long terminal …

[George M. Austin Autobiography Drafts], George M. Austin, Society Of Neurological Surgeons Historian

The Dr. George M. Austin Neurology Research Collection

George M. Austin autobiography drafts.

1. Draft dated September 26, 1994.
2. “First Draft” dated September 21, 1994
3. Draft handwritten on lined yellow paper
4. Typed letter. To All members Society of Neurological Surgeons From Historian. Letter requests a biography and photograph.

Factors Altering Aneurysm Wall Strain, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Factors Altering Aneurysm Wall Strain. George M. Austin, M.D. Poster presentation. American Association of Neurological Surgeons, San Diego Convention Center. April 9-14, 1994. 1 pg.

Brain Aneurysms And Aging, G. M. Austin, W. Schievink, D. Dickson

The Dr. George M. Austin Neurology Research Collection

Brain Aneurysms and Aging. G. M. Austin, M.D., W. Schievink, M.D., and D. Dickson, M.D., 1994. Presentation manuscript. 1 pg.

A Genetic Basis For Brain Aneurysms, G. Austin, W. Schievink, D. Dickson, S. Richardson

The Dr. George M. Austin Neurology Research Collection

A Genetic Basis for Brain Aneurysms. Austin, G., Schievenk, W., Dickson, D., and Richardson, S. Brain Aneurysm Research Laboratory, Neuroscience Institute, U.C.S.B., Santa Barbara, CA. A handwritten note indicates that this is an abstract presented at the Biophysical Society, February 12-16, 1995. 2 pg.

Abstract: Genetic Changes In Brain Aneurysm Wall Protein, G. Austin, W. Schievink, D. Dickson, S. Harris, B. Blackbourne, S. Richardson

The Dr. George M. Austin Neurology Research Collection

Genetic Changes in Brain Aneurysm Wall Protein. G. Austin, W. Schievink, D. Dickson, S. Harris, B. Blackbourne, S. Richardson, Brain Aneurysm Research Laboratory, Neuroscience Institute, University of California at Santa Barbara, N.d. [c.1994?] Abstract.

The Role Of Methylation And Chromatin Structure In The Regulation Of The O6-Methylguanine-Dna Methyltransferase (Mgmt) Gene In Human Glioma Cells, Joseph F. Costello

Dissertations

No abstract provided.