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Musculoskeletal, Neural, and Ocular Physiology Commons™
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Full-Text Articles in Musculoskeletal, Neural, and Ocular Physiology
Bridging The Gap Between Muscle And Bone: Examining Tendon Identity And Development, Amel Sassi
Bridging The Gap Between Muscle And Bone: Examining Tendon Identity And Development, Amel Sassi
Undergraduate Student Research Internships Conference
Tendons are fibrous connective tissues that connect skeletal muscle to bone. Functioning primarily to facilitate locomotion, these tissues are rich with collagen and other minor collagens and proteoglycans. Nevertheless, with over 4000 tendons in the human body, the molecular pathways that define different tendons remain largely unknown. As such, the clear distinction between tendon identity, particularly at the genetic level has yet to be fully established. Similarly, molecular pathways involved in tendon developments remain to be fully elucidated. Despite the important role of tendons in motor coordination and posture, a number of areas in tendon development and identity have yet …
Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve
Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve
The Summer Undergraduate Research Fellowship (SURF) Symposium
The field of regenerative medicine seeks to create replacement tissues and organs, both to repair deficiencies in biological function and to treat structural damage caused by injury. Scaffoldings mimicking extracellular matrix (ECM), the structure to which cells attach to form tissues, have been developed from synthetic polymers and also been prepared by decellularizing adult tissue. However, the structure of ECM undergoes significant remodeling during natural tissue repair, suggesting that ECM-replacement constructs that mirror developing tissues may promote better regeneration than those modeled on adult tissues. This work investigated the effectiveness of a method of viewing the extracellular matrix of developing …