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Angiotensin Ii Induction Of Regional Effects In Murine Vasculature, Albert Phillip Owens Iii
Angiotensin Ii Induction Of Regional Effects In Murine Vasculature, Albert Phillip Owens Iii
University of Kentucky Doctoral Dissertations
The renin angiotensin system (RAS) exerts many diverse physiological functions throughout the body, mediated by its effector peptide, angiotensin II (AngII). AngII has been linked with a variety of different functions ranging from the initiation of severe vascular pathologies, such as atherosclerosis and abdominal aortic aneurysm (AAA), to mundane physiological processes of fluid homeostasis, vascular contraction, and regulation of blood pressure. To provide a potential link between these functions, an in-depth analysis of regional effects of AngII on aortic vasculature was performed.
The studies presented in this dissertation tested the overall hypothesis of whether regional changes exist in the vasculature …