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Full-Text Articles in Medical Toxicology
Antidepressant Effects In Hybrid Striped Bass: Moving From External Exposures To Internal Doses, Lauren Sweet
Antidepressant Effects In Hybrid Striped Bass: Moving From External Exposures To Internal Doses, Lauren Sweet
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Over 47 percent of Americans take at least one prescription drug per month and of these pharmaceuticals, antidepressants are the third most prescribed drug. Their widespread and prolonged use coupled with incomplete removal during wastewater treatment processes has made them one of the most commonly detected pharmaceuticals in the aquatic environment. Antidepressants are intended to modify human behavior by altering brain chemistry and the neurotransmitter receptor targets of these chemicals are highly conserved in many vertebrate species; thus, aquatic organisms may be at risk. Previous research in our lab has shown that exposure of hybrid striped bass (HSB) (Morone saxatilis …
Impacts Of Psychotropic Pharmaceuticals On Hybrid Striped Bass: Altered Predation Behavior As A Function Of Changes In Brain Chemistry, Joseph Bisesi
Impacts Of Psychotropic Pharmaceuticals On Hybrid Striped Bass: Altered Predation Behavior As A Function Of Changes In Brain Chemistry, Joseph Bisesi
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Advances in Analytical Chemistry have led to the detection of low concentrations of pharmaceuticals and personal care products (PPCPs) in wastewater treatment plant effluents as well as their receiving waters. Antidepressants are routinely found among these contaminants, but have been shown to be relatively non-toxic at environmentally measured concentrations using traditional toxicity testing techniques. The neurochemical mode of action of antidepressants warrants investigation of the effects these chemicals may have on fish behavior due to the highly conserved nature of neurotransmitter transporter targets. Using a predator prey bioassay designed in our laboratory, previous studies has shown that the antidepressant fluoxetine …