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Articles 1 - 2 of 2
Full-Text Articles in Medical Toxicology
A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, Richard Vogel, Troy Seidle, Horst Spielmann
A Modular One-Generation Reproduction Study As A Flexible Testing System For Regulatory Safety Assessment, Richard Vogel, Troy Seidle, Horst Spielmann
Troy Seidle, PhD
The European Union’s Registration, Evaluation and Authorisation of Chemicals (REACH) legislation mandates testing and evaluation of approximately 30,000 existing substances within a short period of time, beginning with the most widely used “high production volume” (HPV) chemicals. REACH testing requirements for the roughly 3000 HPV chemicals specify three separate tests for reproductive toxicity: two developmental toxicity studies on different animal species (OECD Test Guideline 414) and a two-generation reproduction toxicity study (OECD TG 416). These studies are highly costly in both economic and animal welfare terms. OECD TG 416 is a fertility study intended to evaluate reproductive performance of animals …
Physicochemical And Metabolic Basis For The Differing Neurotoxicity Of The Pyrrolizidine Alkaloids, Trichodesmine And Monocrotaline, R. J. Huxtable, C. C. Yan, S. Wild, S. Maxwell, Roland Cooper
Physicochemical And Metabolic Basis For The Differing Neurotoxicity Of The Pyrrolizidine Alkaloids, Trichodesmine And Monocrotaline, R. J. Huxtable, C. C. Yan, S. Wild, S. Maxwell, Roland Cooper
Roland A. Cooper