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Multifactorial Modulation Of The Blood-Brain Barrier: Relationship To Stroke, Bei Zhang
Multifactorial Modulation Of The Blood-Brain Barrier: Relationship To Stroke, Bei Zhang
Theses and Dissertations--Nutritional Sciences
The blood-brain barrier (BBB) is a dynamic interface, mainly consisting of highly specialized brain microvascular endothelial cells (BMECs) that segregate the central nervous system (CNS) from the peripheral circulation. Impairment of the BBB, due to disruption of tight junction (TJ) proteins and inflammatory responses, may initiate and/or contribute to the progress of CNS disorders, including stroke. Stroke is the second leading cause of death worldwide. It has been shown that aging and environmental pollutants can induce brain endothelium dysfunction, and are considered as risk factors for stroke.
Deficiency of telomerase is highly linked with aging-associated vascular diseases. Evidence indicates that …