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Full-Text Articles in Medical Physiology

Proliferation Of Acid-Secretory Cells In The Kidney During Adaptive Remodelling Of The Collecting Duct, Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A. Wagner Oct 2011

Proliferation Of Acid-Secretory Cells In The Kidney During Adaptive Remodelling Of The Collecting Duct, Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A. Wagner

Desa Welsh

The renal collecting duct adapts to changes in acid-base metabolism by remodelling and altering the relative number of acid or alkali secreting cells, a phenomenon termed plasticity. Acid secretory A intercalated cells (A-IC) express apical H+-ATPases and basolateral bicarbonate exchanger AE1 whereas bicarbonate secretory B intercalated cells (B-IC) express basolateral (and apical) H+-ATPases and the apical bicarbonate exchanger pendrin. Intercalated cells were thought to be terminally differentiated and unable to proliferate. However, a recent report in mouse kidney suggested that intercalated cells may proliferate and that this process is in part dependent on GDF-15. Here we extend these observations to …


Wavelet-Based Functional Mixed Models To Characterize Population Heterogeneity In Accelerometer Profiles: A Case Study. , Jeffrey S. Morris, Cassandra Arroyo, Brent A. Coull, Louise M. Ryan, Steven L. Gortmaker Dec 2006

Wavelet-Based Functional Mixed Models To Characterize Population Heterogeneity In Accelerometer Profiles: A Case Study. , Jeffrey S. Morris, Cassandra Arroyo, Brent A. Coull, Louise M. Ryan, Steven L. Gortmaker

Jeffrey S. Morris

We present a case study illustrating the challenges of analyzing accelerometer data taken from a sample of children participating in an intervention study designed to increase physical activity. An accelerometer is a small device worn on the hip that records the minute-by-minute activity levels of the child throughout the day for each day it is worn. The resulting data are irregular functions characterized by many peaks representing short bursts of intense activity. We model these data using the wavelet-based functional mixed model. This approach incorporates multiple fixed effects and random effect functions of arbitrary form, the estimates of which are …


Signal Transduction: Rhomantic Interludes Raise Blood Pressure, Andrew P. Somlyo Oct 1997

Signal Transduction: Rhomantic Interludes Raise Blood Pressure, Andrew P. Somlyo

Jama S. Coartney

No abstract provided.