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Articles 1 - 5 of 5
Full-Text Articles in Medical Physiology
Irritable Bowel Syndrome: Proposed Mechanisms Of Pathophysiology And The Underlying Dysregulation Of Brain-Gut Interaction, Hailey Haddix
Irritable Bowel Syndrome: Proposed Mechanisms Of Pathophysiology And The Underlying Dysregulation Of Brain-Gut Interaction, Hailey Haddix
Senior Honors Theses
Irritable bowel syndrome (IBS) is a disease of the gastrointestinal tract affecting approximately 11-21% of people worldwide (Xiao et al., 2021). This research focuses on the dysregulation of gut homeostasis in IBS and explains how the pathophysiology of the gut is controlled by the bidirectional brain-gut axis. The mechanisms of the brain-gut axis consist of neuro-immune cross talk, neuro-hormone cross talk, microbiome-gut signaling, and the HPA-axis. Each of these contribute to one or more of the possible phenotypes of gut pathophysiology, which could include intestinal permeability, visceral hypersensitivity, and motility disturbance (Xiao et al., 2021). Stress is also an important …
The Pathology And Treatment Of Osteoporosis, Shea Munnikhuysen
The Pathology And Treatment Of Osteoporosis, Shea Munnikhuysen
Senior Honors Theses
Osteoporosis is a disease that causes bone fragility and decreased bone mass. Osteocytes and signaling molecules regulate the function of osteoclasts and osteoblasts. The RANK pathway is a key regulator in osteoclastogenesis. When the osteoclastic function is greater than osteoblastic function, bone integrity decreases. Causes of osteoporosis include hormones, medications, and diet. Treatments for osteoporosis are hormonal, medicinal, and lifestyle changes. More research needs to be done to find more effective medications with fewer negative side effects to improve the overall quality of life for patients. Currently, lab trials are being done on potential new medications to treat osteoporosis.
Anxiety In Alzheimer's Disease, Zachary Cooper
Anxiety In Alzheimer's Disease, Zachary Cooper
Senior Honors Theses
Researchers familiar with Alzheimer’s disease have often noted the presence of comorbid anxiety symptomatology. Likewise, the occurrence of anxiety before the development of Alzheimer’s disease has been prevalent enough to warrant attention. This review seeks to elaborate on the pathophysiology behind these two conditions, and to accentuate overlapping aspects that promote a causal relationship between these two pathologies on the macroscopic and cellular levels. Subsequent evidence will show that these pathologies are not independent of each other, and that cellular mechanisms of pathology hint at their interrelatedness. Areas requiring further research that would clarify the relationship between Clinical Anxiety and …
Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin
Senior Honors Theses
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is …
Diabetic Ketoacidosis: Pathophysiology And Treatment, Laura E. Mumme
Diabetic Ketoacidosis: Pathophysiology And Treatment, Laura E. Mumme
The Kabod
The pathophysiology of DKA in patients with T1D is addressed, followed by a discussion of proper emergency treatment for this life-threatening condition.