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Articles 1 - 4 of 4
Full-Text Articles in Medical Pathology
Age-Dependent Mineralization And Osteogenesis In Intact & Injured Murine Bones: A Histological And Immunochemical Study, Amogh Chittajallu
Age-Dependent Mineralization And Osteogenesis In Intact & Injured Murine Bones: A Histological And Immunochemical Study, Amogh Chittajallu
Honors Scholar Theses
Bones function as living organs through their mineralized matrix and specialized cell populations, which provide structural support and enable movement, while storing minerals and creating a space for blood cell production in the marrow1. As individuals age, hormonal changes reduce osteoblast activity while osteoclast-mediated bone resorption persists, resulting in lower mineral density and heightened fracture risk2. We examined how aging impacts young and old murine femurs because these models display bone structure and cellular organization that closely resemble human long bones. This research study used six distinct histological stains to observe essential features of bone tissue …
Review Of The Diagnosis, Pathophysiology, And Treatment Of Naegleria Fowleri-Induced Primary Amoebic Meningoencephalitis, Terrance Zhang
Review Of The Diagnosis, Pathophysiology, And Treatment Of Naegleria Fowleri-Induced Primary Amoebic Meningoencephalitis, Terrance Zhang
MCB Articles
Naegleria fowleri is a thermophilic, ubiquitous, free-living amoeba, but is also known as the “brain-eating” amoeba. This is the etiological agent of a rare and fulminant waterborne disease known as Primary Amoebic Meningoencephalitis (PAM) that is acutely fatal in 90-99% of reported cases. Those who come into contact with infested waters are at risk of introducing the amoeba into their upper nasal canal, whence the trophozoite form is known to migrate along the olfactory nerve, through the cribriform plate, and enter the central nervous system. Although the exact pathogenesis of N. fowleri is not known, studies have demonstrated contact-dependent and …
Acute Kidney Injury In The Elderly, Zachary Palanza
Acute Kidney Injury In The Elderly, Zachary Palanza
Honors Scholar Theses
Acute kidney injury (AKI) is a significant clinical concern in the elderly, marked by heightened incidence rates, increased morbidity and mortality, and impaired kidney repair mechanisms. AKI often has severe consequences, including extended hospital stays, heightened rates of chronic kidney disease, and elevated healthcare costs. The vulnerability of elderly individuals to AKI is amplified by age-related structural and functional changes in the kidneys, reduced physiological reserve, and increased exposure to nephrotoxic agents. The impaired kidney repair mechanisms observed in the elderly pose further complexities in AKI management. With age, the regenerative capacity of the kidneys diminishes, resulting in incomplete recovery …
In Vitro Exploration Of Macrophage Migration Inhibitory Factor (Mif) As A Possible Agent Of Lymphatic Dilation In The Pathogenesis Of Lymphatic Filiariasis, Lauren Rosen
Honors Scholar Theses
Abstract:Macrophage Migration Inhibitory Factor (MIF) is a human cytokine that is well known for its role in modulating macrophage function. It has also been shown to cause smooth muscle cell death. A homolog of the MIF protein (BmMIF) has been found in Brugia malayi, one of the etiological agents of lymphatic filariasis. BmMIF shares a significant portion of its sequence homology with human MIF. Infection by Brugia malayi leads to a consistent finding of lymphatic dilation with surrounding smooth muscle cell apoptosis. We hypothesize that Brugia malayi releases BmMIF as a mediator of host smooth muscle cell death in the …