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Articles 1 - 6 of 6
Full-Text Articles in Medical Pathology
Anti-Adamts13 Autoantibodies In Immune-Mediated Thrombotic Thrombocytopenic Purpura, Robert W. Maitta
Anti-Adamts13 Autoantibodies In Immune-Mediated Thrombotic Thrombocytopenic Purpura, Robert W. Maitta
Faculty Scholarship
Autoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion. Under normal physiologic conditions, antibodies are generated in response to foreign antigens, which can include infectious agents; however, these antibodies may at times cross-react with self-epitopes. This is one of the possible mechanisms mediating formation of anti-ADAMTS13 autoantibodies. The process known as “antigenic mimicry” may be responsible for the development of these autoantibodies that recognize and bind cryptic epitopes in ADAMTS13, disrupting its enzymatic function over ultra large von Willebrand factor …
Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta
Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta
Faculty Scholarship
Platelets, traditionally known for their role in hemostasis, have emerged as key players in immune response and inflammation. Sepsis, a life-threatening condition characterized by systemic inflammation, often presents with thrombocytopenia, which at times, can be significant. Platelets contribute to the inflammatory response by interacting with leukocytes, endothelial cells, and the innate immune system. However, excessive platelet activation and consumption can lead to thrombocytopenia and exacerbate the severity of sepsis. Understanding the multifaceted roles of platelets in sepsis is crucial for developing effective therapeutic strategies. Targeting platelet-mediated inflammatory responses and promoting platelet production may offer potential avenues for improving outcomes in …
Alpha Synuclein And Inflammaging, Geneviève L. Putnam, Robert W. Maitta
Alpha Synuclein And Inflammaging, Geneviève L. Putnam, Robert W. Maitta
Faculty Scholarship
The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with inflammasomes in response to aging. As age is an inevitable physiological state and is also considered the greatest risk factor for PD, this calls for investigation into how α-syn, aging, and PD could be linked. There is a growing amount of data regarding α-syn normal function in the body that includes involvement in cellular transport such as protein complexes assembly, vesicular trafficking, neurotransmitter release, …
Editorial: Transfusion Medicine And Blood, Volume Ii, Robert W. Maitta
Editorial: Transfusion Medicine And Blood, Volume Ii, Robert W. Maitta
Faculty Scholarship
No abstract provided.
Bacterial Contamination Of Platelet Products, Michael R. Jacobs `, Bowen Zhou, Robert W. Maitta
Bacterial Contamination Of Platelet Products, Michael R. Jacobs `, Bowen Zhou, Robert W. Maitta
Faculty Scholarship
Transfusion of bacterially contaminated platelets, although rare, is still a major cause of mortality and morbidity despite the introduction of many methods to limit this over the past 20 years. The methods used include improved donor skin disinfection, diversion of the first part of donations, use of apheresis platelet units rather than whole-blood derived pools, primary and secondary testing by culture or rapid test, and use of pathogen reduction. Primary culture has been in use the US since 2004, using culture 24 h after collection of volumes of 4–8 mL from apheresis collections and whole-blood derived pools inoculated into aerobic …
Identifying Exosomes In Oral Squamous Cell Carcinoma With Efirm, Bram Holladay
Identifying Exosomes In Oral Squamous Cell Carcinoma With Efirm, Bram Holladay
Student Scholarship
Oral Squamous Cell Carcinoma (OSCC) affects 53,000 Americans each year making it the sixth most common cancer in the United States. The incidence rate may be even higher since current screening methods are underutilized and physical examinations can misdiagnose malignant oral tumors as benign inflammatory lesions. Recent advances in genetic, protein, and extracellular vesicle biomarker detection techniques can monitor the transformation of healthy cells into tumors before terminal stages arise. Biomarkers can be easily extracted from biofluids such as saliva making them less invasive than traditional tissue biopsies. One biomarker prevalent in OSCC is exosomes, which are extracellular vesicles that …