Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Medical Molecular Biology
Clinical Application Of Oncolytic Viruses: A Systematic Review, Mary Cook, Aman Chauhan
Clinical Application Of Oncolytic Viruses: A Systematic Review, Mary Cook, Aman Chauhan
Internal Medicine Faculty Publications
Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons. However, it was not until the introduction of immune checkpoint inhibitors that we realized the true potential of immunotherapy in combating cancer. Oncolytic viruses are one such immunotherapeutic tool that is currently being explored in cancer therapeutics. We present the most comprehensive systematic review of all oncolytic viruses in Phase 1, 2, and 3 clinical trials published to date. We performed a systematic review of all published clinical trials indexed in PubMed that utilized oncolytic …
Cancer-Targeting Immunostimulatory Peptides As An Immunotherapeutic Approach To Cancer, Rachel Montel
Cancer-Targeting Immunostimulatory Peptides As An Immunotherapeutic Approach To Cancer, Rachel Montel
Seton Hall University Dissertations and Theses (ETDs)
This dissertation reports the synthesis and biological applications of bifunctional trimeric peptides with B7H6-derived NKp30 binding motifs that serve to activate an immunocytotoxic response in natural killer cells and a GRP78-binding motif that can target tumors that express surface GRP78. In this manner the cancer-targeting immunostimulatory peptides are anticipated to directly bind and activate effector NK92-MI cells while also recognizing and binding to target A549 tumor cells to facilitate NK cell-dependent immunocytotoxicity of the targeted tumors. The NKp30 binding peptide motifs are derived from the tumor associated B7H6 antigen that is often downregulated or shed from the surface of tumors …
Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. D'Abramo
Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. D'Abramo
Journal Articles
No abstract provided.