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Relationships Between Telomeric Sequences And Structures, Dna Replication, And The Function Of The Werner Syndrome Protein, Deanna Edwards
Relationships Between Telomeric Sequences And Structures, Dna Replication, And The Function Of The Werner Syndrome Protein, Deanna Edwards
Theses and Dissertations--Toxicology and Cancer Biology
All human chromosomes end with protective structures called telomeres, which consist of thousands of double-stranded TTAGGG repeats and end in a 3’ guanine-rich overhang. These structures shorten normally during each round of replication, and extremely short telomeres along with telomere dysfunction are thought to contribute to the development of aging and cancer. Although many proteins have roles in telomere maintenance, WRN, which is a 3’ to 5’ helicase that is deficient in the premature aging disorder Werner’s syndrome, has been proposed to play multiple roles at telomeres. In this study, I focus on the effect of telomeric sequences and/or structures …