Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Cell Biology (4)
- Bioethics and Medical Ethics (3)
- Medical Genetics (3)
- Cell Biology (2)
- Cell and Developmental Biology (2)
-
- Diseases (2)
- Life Sciences (2)
- Medical Neurobiology (2)
- Medical Specialties (2)
- Molecular and Cellular Neuroscience (2)
- Neuroscience and Neurobiology (2)
- Amino Acids, Peptides, and Proteins (1)
- Animal Diseases (1)
- Bacterial Infections and Mycoses (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Chemicals and Drugs (1)
- Cognitive Neuroscience (1)
- Digestive System Diseases (1)
- Disease Modeling (1)
- Gastroenterology (1)
- Genetic Processes (1)
- Genetics (1)
- Genetics and Genomics (1)
- Infectious Disease (1)
- Medical Biochemistry (1)
- Medical Microbiology (1)
- Keyword
-
- ART (1)
- Alzheimer's (1)
- Alzheimer's disease (1)
- Amyloid Beta (1)
- Attachment (1)
-
- Biology, Cell (1)
- Biology, Molecular (1)
- CRISPR (1)
- Calcium (1)
- Cas9 (1)
- Citrobacter rodentium (1)
- Dementia (1)
- Designer Babies (1)
- E. coli infection (1)
- ESC (1)
- Effacement (1)
- Embryonic stem cells (1)
- Escherichia coli (1)
- Gastrointestinal disease (1)
- Gastrointestinal tract (1)
- Gene expression (1)
- Genetic Engineering (1)
- Glutamate (1)
- HESC (1)
- HiPSC (1)
- IPSC (1)
- IVG (1)
- In Vitro-Derived Eggs (1)
- In Vitro-Derived Sperm (1)
- Induced pluripotent stem cells (1)
Articles 1 - 7 of 7
Full-Text Articles in Medical Molecular Biology
The Role Of Pfkfb3 In Ampk-Activated Glut4 Translocation, Katherine Renee Bosch
The Role Of Pfkfb3 In Ampk-Activated Glut4 Translocation, Katherine Renee Bosch
Senior Honors Theses
Type 2 diabetes is a chronic, potentially deadly disease that impacts millions of Americans’ lives. Type 2 diabetes is characterized by increased blood glucose levels caused by insulin resistance. The normal insulin signaling pathway leads to glucose uptake by GLUT4 through activation of the IRS-1-PI3K-Akt pathway, as well as the insulin-independent pathway that utilizes AMPK. Additionally, PFKFB3 may play a role in insulin signaling and glucose uptake. PFKFB3 is an enzyme that plays an important role in activating PFK-1, which is a rate-limiting enzyme in glycolysis. PFKFB3 is frequently studied for its role in cancer due to its role in …
The Revolutionary Genome Editor: Crispr-Cas9 Systems, Grace Spade
The Revolutionary Genome Editor: Crispr-Cas9 Systems, Grace Spade
Senior Honors Theses
Genetic engineering is the modification of an organism's genetic material to alter its traits through adding, deleting, or changing specific genes. CRISPR-Cas9 systems are groundbreaking tools for genetic engineering, in short utilizing a molecule called RNA to guide a protein called Cas9 to a specific location in DNA to add, delete, or replace genes. The history of how the CRISPR-Cas9 systems came into existence, how it was adapted from a natural defense system in bacteria, and its mechanism of action in both are explained. Its applications, both present and future, competing genetic modifiers, advantages and disadvantages, and the ethical dilemmas …
In Vitro Gametogenesis: A Research Timeline And Implications For The Future Of Assisted Reproductive Technology, Nicole Buckley
In Vitro Gametogenesis: A Research Timeline And Implications For The Future Of Assisted Reproductive Technology, Nicole Buckley
Senior Honors Theses
The novel reproductive technology, In Vitro Gametogenesis (IVG), includes the process of obtaining mature viable germ cells from pluripotent stem cells. To do so, embryonic stem cells and induced pluripotent stem cells are specified to primordial germ cells and differentiated to form gametes that undergo further maturation, which subsequently may undergo in vitro fertilization to form an embryo. With this capability, IVG holds the power to provide a novel treatment option for human infertility. As of now, research has been conducted on mice successfully, and with limited success in humans. Future research will likely focus on discovering the species-specific differences …
Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast
Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast
Senior Honors Theses
This paper reviews functions of Amyloid-β (Aβ) in healthy individuals compared to the consequences of aberrant Aβ in Alzheimer’s disease (AD). As extraneuronal Aβ accumulation and plaque formation are characteristics of AD, it is reasonable to infer a pivotal role for Aβ in AD pathogenesis. Establishing progress of the disease as well as the mechanism of neurodegeneration from AD have proven difficult (Selkoe, 1994). This thesis provides evidence suggesting the pathogenesis of AD is due to dysfunctional neuronal processes involving Aβ’s synaptic malfunction, abnormal interaction with tau, and disruption of neuronal homeostasis. Significant evidence demonstrates that AD symptoms are partially …
Intimin Likely Used To Cause Disease During Competition With Commensal Escherichia Coli, Dominique J. Richburg
Intimin Likely Used To Cause Disease During Competition With Commensal Escherichia Coli, Dominique J. Richburg
Senior Honors Theses
The intimin gene in the Locus of Enterocyte Effacement (LEE) island of pathogenicity is the primary attachment mechanism in Citrobacter rodentium. Intimin is a bacterial adhesin (protein) that attaches to obtain a niche/nutrient and thrive within the intestine. Intimin was deleted within C. rodentium to study colonization and pathogenesis in the murine intestine. Additionally, C. rodentium is an attaching/effacing pathogen, and a useful murine model in understanding Enterohemorrhagic Escherichia coli (EHEC) infection in humans. E. coli and C. rodentium cause gastroenteritis in humans and mice, respectively. C. rodentium is a murine pathogen commonly used to model gastrointestinal disease because …
Gene Expression And Alzheimer's Disease: Evaluation Of Gene Expression Patterns In Brain And Blood For An Alzheimer's Disease Mouse Model, Amanda Hazy
Senior Honors Theses
Previous studies have established a causative role for altered gene expression in development of Alzheimer’s disease (AD). These changes can be affected by methylation and miRNA regulation. In this study, expression of miRNA known to change methylation status in AD was assessed by qPCR. Genome-wide expression changes were determined by RNA-sequencing of mRNA from hippocampus and blood of control and AD mice. The qPCR data showed significantly increased expression of Mir 17 in AD, and sequencing data revealed 230 genes in hippocampus, 58 genes in blood, and 8 overlapping genes showing significant differential expression (p value ≤ 0.05). Expression data …
The Pluripotency Proposition: A Biological And Ethical Case For The Utilization Of Hipscs In Place Of Hescs, Drew Dickson
The Pluripotency Proposition: A Biological And Ethical Case For The Utilization Of Hipscs In Place Of Hescs, Drew Dickson
Senior Honors Theses
Human embryonic stem cell (hESC) research has spurred ethical controversy ever since it became feasible in 1998. The reason for this is due to the fact that hESC research requires the destruction of a human embryo, thereby causing the cessation of life for that developing human. Despite this unavoidable consequence, many advocates of hESC research hold to the belief that the embryo is not actually a human person, and therefore deem the destruction of the embryo as justifiable. Many advocates of hESC research also have pointed to the unprecedented medical potential of hESCs to argue in favor of their case. …