Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Adult (1)
- Aged (1)
- Attachment (1)
- Autoantibodies (1)
- Autoantigens (1)
-
- Biomarkers (1)
- Citrobacter rodentium (1)
- E. coli infection (1)
- Effacement (1)
- Escherichia coli (1)
- Female (1)
- Fluorescent antibody technique (1)
- Gastrointestinal disease (1)
- Gastrointestinal tract (1)
- HeLa cells (1)
- Humans (1)
- Indirect (1)
- Inflammation (1)
- Intimin (1)
- Intimin mutant (1)
- Male (1)
- Middle aged (1)
- Pathogenesis (1)
- Post-transcriptional (1)
- RNA processing (1)
- Scleroderma (1)
- Systemic (1)
- Young adult (1)
- Publication
Articles 1 - 2 of 2
Full-Text Articles in Medical Molecular Biology
Intimin Likely Used To Cause Disease During Competition With Commensal Escherichia Coli, Dominique J. Richburg
Intimin Likely Used To Cause Disease During Competition With Commensal Escherichia Coli, Dominique J. Richburg
Senior Honors Theses
The intimin gene in the Locus of Enterocyte Effacement (LEE) island of pathogenicity is the primary attachment mechanism in Citrobacter rodentium. Intimin is a bacterial adhesin (protein) that attaches to obtain a niche/nutrient and thrive within the intestine. Intimin was deleted within C. rodentium to study colonization and pathogenesis in the murine intestine. Additionally, C. rodentium is an attaching/effacing pathogen, and a useful murine model in understanding Enterohemorrhagic Escherichia coli (EHEC) infection in humans. E. coli and C. rodentium cause gastroenteritis in humans and mice, respectively. C. rodentium is a murine pathogen commonly used to model gastrointestinal disease because …
Stress Granules And Rna Processing Bodies Are Novel Autoantibody Targets In Systemic Sclerosis, Michael E. Johnson, Andrew V. Grassetti, Jaclyn N. Taroni, Shawn M. Lyons, Devin Schweppe, Jessica K. Gordon, Robert F. Speira, Robert Lafyatis, Paul J. Anderson, Scott A. Gerber, Michael L. Whitfield
Stress Granules And Rna Processing Bodies Are Novel Autoantibody Targets In Systemic Sclerosis, Michael E. Johnson, Andrew V. Grassetti, Jaclyn N. Taroni, Shawn M. Lyons, Devin Schweppe, Jessica K. Gordon, Robert F. Speira, Robert Lafyatis, Paul J. Anderson, Scott A. Gerber, Michael L. Whitfield
Dartmouth Scholarship
Autoantibody profiles represent important patient stratification markers in systemic sclerosis (SSc). Here, we performed serum-immunoprecipitations with patient antibodies followed by mass spectrometry (LC-MS/MS) to obtain an unbiased view of all possible autoantibody targets and their associated molecular complexes recognized by SSc.