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Full-Text Articles in Medical Molecular Biology
Clinical Application Of Oncolytic Viruses: A Systematic Review, Mary Cook, Aman Chauhan
Clinical Application Of Oncolytic Viruses: A Systematic Review, Mary Cook, Aman Chauhan
Internal Medicine Faculty Publications
Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons. However, it was not until the introduction of immune checkpoint inhibitors that we realized the true potential of immunotherapy in combating cancer. Oncolytic viruses are one such immunotherapeutic tool that is currently being explored in cancer therapeutics. We present the most comprehensive systematic review of all oncolytic viruses in Phase 1, 2, and 3 clinical trials published to date. We performed a systematic review of all published clinical trials indexed in PubMed that utilized oncolytic …