Medical Molecular Biology Commons^™

Steady-State Regulation Of Secretory Cargo Export And Er Homeostasis By Inositol Trisphosphate Receptors And Penta-Ef-Hand Proteins, Aaron J. Held

Graduate Student Theses, Dissertations, & Professional Papers

Constant protein degradation and turnover necessitates constitutive secretion that delivers the correct mix of nascent proteins to their appropriate subcellular destinations. Cells thus exhibit steady-state secretion and the additional ability to adjust secretory flux, though we lack a clear understanding of this critical process. During secretion, the COPII coat is responsible for providing a balance of actively and passively selected ER cargos to enter the secretory pathway. Furthermore, Ca²⁺ -binding proteins have been implicated in regulating this process in response to Ca²⁺ signals. In Chapter 1, we review the secretory pathway and vesicular trafficking, with a focus on …