Medical Microbiology Commons^™

Roles Of Three Transporters, Cbcxwv, Bett1, And Bett3, In Pseudomonas Aeruginosa Choline Uptake For Catabolism, Adel A. Malek, Chiliang Chen, Matthew J. Wargo, Gwyn A. Beattie, Deborah A. Hogan

Dartmouth Scholarship

Pseudomonas aeruginosa uses the quaternary amine choline as a carbon source, osmoprotectant, and macromolecular precursor. The importance of choline in P. aeruginosa physiology is highlighted by the presence of multiple known and putative choline transporters encoded within its genome. This report describes the relative roles of three choline transporters, the ABC transporter CbcXWV and two symporters, BetT1 and BetT3, in P. aeruginosa growth on choline under osmotic conditions that are physiologically relevant to eukaryotic hosts. The increased lag phases exhibited by the ΔbetT1 and ΔbetT1 ΔbetT3 mutants relative to the wild type upon transfer to medium with …