Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Bioethics and Medical Ethics (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Circulatory and Respiratory Physiology (1)
-
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
- Health Psychology (1)
- Medical Cell Biology (1)
- Medical Specialties (1)
- Obstetrics and Gynecology (1)
- Oncology (1)
- Other Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Psychology (1)
- Respiratory Tract Diseases (1)
- Social and Behavioral Sciences (1)
Articles 1 - 3 of 3
Full-Text Articles in Medical Genetics
Understanding Pseudomonas Aeruginosa Alginate Regulation And Its Link To Chronic Lung Infections In Cystic Fibrosis Patients, Roy Al Ahmar
Understanding Pseudomonas Aeruginosa Alginate Regulation And Its Link To Chronic Lung Infections In Cystic Fibrosis Patients, Roy Al Ahmar
Theses, Dissertations and Capstones
Cystic Fibrosis (CF) is a genetic disorder caused by mutations in the gene encoding Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). This disorder results in thick lung secretions which compromise the patient’s immune system. Chronic lung infections with Pseudomonas aeruginosa biofilms is a major factor that contributes to poor outcome for clinical treatment. The overall hypothesis of this dissertation is that small colony variant and pyrimidine biosynthesis are linked with biofilm formation, alginate production is dependent on MucA proteolysis, rifaximin can be repurposed to treat biofilm infection and multiplex PCR can be used to rapidly measure the bacterial cell density in …
Saying ‘No’: A Biographical Analysis Of The Experiences Of Women With A Genetic Predisposition To Developing Breast/Ovarian Cancer Who Reject Risk Reducing Surgery, Doreen Molloy
Theses: Doctorates and Masters
Background: Genetic technologies have identified some of the genes implicated in cancer susceptibility. Women with mutations in breast/ovarian cancer-susceptibility genes (BRCA1 and 2) have a lifetime combined risk of breast/ovarian cancer of more than 80%. Risk reducing surgery (RRS) reduces cancer risk by as much as 90% in high risk populations. Despite this, some BRCA1/2 mutation-positive women say no to RRS.
Purpose: To illuminate an understanding of why women at high risk of developing breast/ovarian cancer say no to risk reducing surgery (RRS).
Design: Denzin’s (1989) interpretive biography was combined with Dolby-Stahl’s (1985) literary folkloristic methodology to provide a contextualised …
Cystic Fibrosis: Biological And Ethical Considerations, Sarah Elizabeth Milam
Cystic Fibrosis: Biological And Ethical Considerations, Sarah Elizabeth Milam
Honors Theses
Cystic fibrosis (CF) is a progressive, multisystem disease whose etiology is a genetic mutation in the CF gene product, cystic fibrosis transmembrane conductance regulator (CFTR). The disorder affects all exocrine glands, with common symptoms involving the lungs and pancreas. Although the CF gene and its protein product have been identified, two aspects of the disease make CF particularly difficult to diagnose and manage: (a) variability in both degree and pattern of the mutation in different individuals and (b) lack of information regarding the precise molecular and cellular mechanisms responsible. Let us begin by examining the pathogenesis and pathophysiology of the …