Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
Articles 1 - 4 of 4
Full-Text Articles in Medical Genetics
Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle
Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle
School of Medicine Faculty Publications
No abstract provided.
A Patient-Derived Ipsc Model To Study Glutamate Deficiency By Shank-3 Mutation In Autism Spectrum Disorder, Tiffany Berry, Courtney Caccia
A Patient-Derived Ipsc Model To Study Glutamate Deficiency By Shank-3 Mutation In Autism Spectrum Disorder, Tiffany Berry, Courtney Caccia
Biology Student Scholarship
Tiffany Berry ’22, Majors: Biology and Psychology
Courtney Caccia ’22, Majors: Biology and Psychology
Faculty Mentor: Dr. Charles Toth, Biology
The use of human stem cell lines derived from persons with Autism Spectrum Disorder (ASD) provides a unique opportunity to model brain growth and potential to regain brain activity for treatment. Our lab has previously used stem cells to derive 3D cardiomyocytes to examine cardiovascular disease as well as kidney organoids and macrophages to study kidney disease. Using techniques our lab has learned using these stem cell models have prepared us to examine cell communication in mutated neurons. We will …
Extracellular Mechanotransduction, Stephen J. Haller, Andrew T. Dudley
Extracellular Mechanotransduction, Stephen J. Haller, Andrew T. Dudley
Journal Articles: Genetics, Cell Biology & Anatomy
We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Mintruls: Prediction Of Mirna-Mrna Target Site Interactions Using Regularized Least Square Method, Sushil Kumar Shakyawar, Siddesh Southekal, Chittibabu Guda
Mintruls: Prediction Of Mirna-Mrna Target Site Interactions Using Regularized Least Square Method, Sushil Kumar Shakyawar, Siddesh Southekal, Chittibabu Guda
Journal Articles: Genetics, Cell Biology & Anatomy
Identification of miRNA-mRNA interactions is critical to understand the new paradigms in gene regulation. Existing methods show suboptimal performance owing to inappropriate feature selection and limited integration of intuitive biological features of both miRNAs and mRNAs. The present regularized least square-based method, mintRULS, employs features of miRNAs and their target sites using pairwise similarity metrics based on free energy, sequence and repeat identities, and target site accessibility to predict miRNA-target site interactions. We hypothesized that miRNAs sharing similar structural and functional features are more likely to target the same mRNA, and conversely, mRNAs with similar features can be targeted by …