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Medical Biomathematics and Biometrics Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Medical Biomathematics and Biometrics
Assessing The Adequacy Of A Prediction Model, Abhaya Indrayan, Sakshi Mishra Ms
Assessing The Adequacy Of A Prediction Model, Abhaya Indrayan, Sakshi Mishra Ms
COBRA Preprint Series
No abstract provided.
Supervised Dimension Reduction For Large-Scale "Omics" Data With Censored Survival Outcomes Under Possible Non-Proportional Hazards, Lauren Spirko-Burns, Karthik Devarajan
Supervised Dimension Reduction For Large-Scale "Omics" Data With Censored Survival Outcomes Under Possible Non-Proportional Hazards, Lauren Spirko-Burns, Karthik Devarajan
COBRA Preprint Series
The past two decades have witnessed significant advances in high-throughput ``omics" technologies such as genomics, proteomics, metabolomics, transcriptomics and radiomics. These technologies have enabled simultaneous measurement of the expression levels of tens of thousands of features from individual patient samples and have generated enormous amounts of data that require analysis and interpretation. One specific area of interest has been in studying the relationship between these features and patient outcomes, such as overall and recurrence-free survival, with the goal of developing a predictive ``omics" profile. Large-scale studies often suffer from the presence of a large fraction of censored observations and potential …