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- <p>Prostate<strong> -- </strong>Cancer -- Research.</p> <p>Gene therapy -- Research.</p> (1)
- Afferent postsynaptic density (PSD) (1)
- Apoptosis Induction (1)
- Auditory brainstem response (ABR) (1)
- Cochlea (1)
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- Gene Therapy (1)
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- Idebenone (1)
- Inner hair cell (1)
- LHON (1)
- Leber's Hereditary Optic Neuropathy (1)
- Microbubbles (1)
- Mitochondria (1)
- MtDNA (1)
- Prostate Cancer (1)
- Retinal Ganglion (1)
- Shank (1)
- Systemic targeted viral gene delivery (1)
- Ultrasound (1)
- Ultrasound Contrast Agents (1)
- Vestibular evoked potentials (VsEPs) (1)
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Articles 1 - 3 of 3
Full-Text Articles in Genetic Structures
An Overview Of Leber’S Hereditary Optic Neuropathy, Matthew R. Dalton
An Overview Of Leber’S Hereditary Optic Neuropathy, Matthew R. Dalton
The Kabod
Typically affecting males ranging from 20 to 24 years of age, Leber’s Hereditary Optic Neuropathy (LHON) is a disorder that is characterized by an acute loss of central vision. Although a heritable disease, LHON does not follow the patterns of classical Mendelian genetics. In fact, one of the most striking characteristics of LHON is that the disease is virtually always inherited maternally. Unlike most genetic disorders that result from a mutation in genomic DNA, LHON is caused by a mutation in the genetic information of mitochondria (mtDNA). Currently there is no treatment for LHON. Despite this, pharmaceutical interventions and contemporary …
Deletion Of Shank1 Has Minimal Effects On The Molecular Composition And Function Of Glutamatergic Afferent Postsynapses In The Mouse Inner Ear, Jeremy P. Braude, Sarath Vijayakumar, Katherine Baumgarner, Rebecca Laurine, Timothy A. Jones, Sherri M. Jones, Sonya J. Pyott
Deletion Of Shank1 Has Minimal Effects On The Molecular Composition And Function Of Glutamatergic Afferent Postsynapses In The Mouse Inner Ear, Jeremy P. Braude, Sarath Vijayakumar, Katherine Baumgarner, Rebecca Laurine, Timothy A. Jones, Sherri M. Jones, Sonya J. Pyott
Department of Special Education and Communication Disorders: Faculty Publications
Abstract
Shank proteins (1-3) are considered the master organizers of glutamatergic postsynaptic densities in the central nervous system, and the genetic deletion of either Shank1, 2, or 3 results in altered composition, form, and strength of glutamatergic postsynapses. To investigate the contribution of Shank proteins to glutamatergic afferent synapses of the inner ear and especially cochlea, we used immunofluorescence and quantitative real time PCR to determine the expression of Shank1, 2, and 3 in the cochlea. Because we found evidence for expression of Shank1 but not 2 and 3, we investigated the morphology, composition, and function of afferent postsynaptic densities …
Investigation Of Ultrasound Targeted Microbubbles As A Therapeutic Gene Delivery System For Prostate Cancer, Rounak Paramjeet Nande
Investigation Of Ultrasound Targeted Microbubbles As A Therapeutic Gene Delivery System For Prostate Cancer, Rounak Paramjeet Nande
Theses, Dissertations and Capstones
A major challenge for effective gene therapy is systemic delivery of viruses carrying therapeutic genes into affected tissue. The immunogenic nature of human adenoviruses (Ads) limits their use for intratumoral (IT) injection in gene therapy. Ads transfection is further hampered by the fluctuating presence of Coxsackie and Adenovirus Receptor (CAR) and integrins on the cells’ surface. To circumvent these limitations we developed a novel approach wherein Ads are encapsulated inside the shell of lyophilized, lipid-encapsulated, perfluorocarbon microbubbles (MBs)/ultrasound (US) contrast agents, which act as delivery vehicles for a sitespecific gene transfer system.
We performed infection studies with Ad.GFP (Green Fluorescent …