Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Diseases (4)
- Medical Cell Biology (3)
- Life Sciences (2)
- Neoplasms (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
-
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Fungi (1)
- Genetic Structures (1)
- Immune System Diseases (1)
- Laboratory and Basic Science Research (1)
- Medical Genetics (1)
- Medical Immunology (1)
- Molecular Biology (1)
- Nervous System Diseases (1)
- Neuroscience and Neurobiology (1)
- Organisms (1)
- Therapeutics (1)
- Institution
- Keyword
-
- Apoptosis (2)
- <p>Alcohol - Physiological effect - Research.</p> <p>Alcoholic liver diseases.</p> <p>Ethanol - pharmacology.</p> (1)
- Alcohol abuse (1)
- Alcoholic liver disease (1)
- Autoimmune Diseases (1)
-
- Blood (1)
- Breast Cancer (1)
- CXCR4 (1)
- Ferritin (1)
- Fungal genetics (1)
- Gene Transcription (1)
- Gliotoxin (1)
- HIF1A (1)
- Hematopoiesis (1)
- Hemgn (1)
- Hypoxia (1)
- Influenza A (1)
- Influenza Reassortment (1)
- Interleukin-23 (1)
- Iron deficiency (1)
- Knockout (1)
- Lysine acetylation (1)
- MSA (1)
- Metastasis (1)
- North American Swine Influenza Viruses. (1)
- Oxidative stress (1)
- Peptides (1)
- Purkinje cells (1)
- SDF-1 (1)
- Stem cell (1)
Articles 1 - 7 of 7
Full-Text Articles in Genetic Processes
Identification Of Novel Hif1a Target Genes That Regulate Tumor Progression And Metastasis, Danielle L. Peacock
Identification Of Novel Hif1a Target Genes That Regulate Tumor Progression And Metastasis, Danielle L. Peacock
Theses and Dissertations (ETD)
Hypoxia is a hallmark of most solid tumors. In response to hypoxic stress tumor cells adapt by regulating survival, metabolism and angiogenesis. The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical aspects of cancer biology including angiogenesis, stem cell maintenance, metabolic reprogramming, invasion, metastasis and resistance to radiation therapy and chemotherapy. Overexpression of HIF-1α and HIF-2α has been documented in multiple human cancers and HIF-1 protein is over-expressed in ~30% of primary breast tumors and ~70% of metastases, which independently correlates with poor prognosis and decreased survival in …
Novel Inducers Of Gliotoxin Production In Aspergillus Fumigatus, Taylor J. Schoberle
Novel Inducers Of Gliotoxin Production In Aspergillus Fumigatus, Taylor J. Schoberle
Dissertations and Theses (Open Access)
Secondary metabolites are produced by numerous organisms and can either be benign to humans or harmful. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often located in subtelomeric regions of the chromosome. These clusters are often coordinately regulated, being almost exclusively dependent on transcription factors that are located within the clusters themselves. Secondary metabolites are also regulated by a variety of factors, including nutritional factors, environmental factors and developmental processes. Gliotoxin, which is produced by a variety of Aspergillus species, Trichoderma species, and Penicillium species, exhibits immunosuppressive properties and …
Expression Of The Chemokine Receptor, Cxcr4, And Its Ligand, Sdf-1, Are Increased In Purkinje Cells Of The Multiple System Atrophy Cerebellum, Megan Welter
Masters Theses
Multiple System Atrophy (MSA) is a sporadic, neurodegenerative disease that consists of three conditions: autonomic dysfunction, Parkinsonism and cerebellar ataxia. Our lab conducted an Affymetrix global gene expression analysis using pons tissue of MSA patients to determine genes that are differentially expressed when compared to non- MSA controls. This study identified upregulated genes, including the C-X-C chemokine receptor type 4, CXCR4, to which stromal cell-derived factor-I (SDF-1) is the natural ligand. The CXCR4/SDF-1 signaling pair has been sho.wn to play multiple roles in the brain, such as inducing neuronal apoptosis and promoting leukocyte recruitment during inflammation. The MSA cerebellum presents …
Virologic Factors Contributing To The Genetic Diversification Of Influenza Viruses Circulating In North American Swine, Thomas Paul Fabrizio Ii
Virologic Factors Contributing To The Genetic Diversification Of Influenza Viruses Circulating In North American Swine, Thomas Paul Fabrizio Ii
Theses and Dissertations (ETD)
The purpose of this study was to determine mechanisms of reassortment of swine influenza viruses and determine if certain reassortant gene combinations can drive evolution and host adaptation in the context of the triple reassortant internal gene (TRIG) cassette. The TRIG contains a unique combination of a human polymerase basic 1 (PB1) gene with avian polymerase basic 2 (PB2) and polymerase acidic (PA) genes. The remaining internal genes, nucleoprotein (NP), matrix (M), and non-structural (NS) are of swine origin. This differs considerably from classical swine lineage viruses which are drifted variants of the 1918 pandemic with all swine origin genes. …
Functional Study Of Hemogen Knockout Mouse Model, Peng Gao
Functional Study Of Hemogen Knockout Mouse Model, Peng Gao
Theses and Dissertations (ETD)
Mouse Hemogen (Hemgn) is regarded as a homologue of human Erythroid Differentiation Associated Gene (EDAG). EDAG overexpression has been postulated for association with some leukemia cases. Meanwhile, Hemgn has been found to contribute to Hoxb4 mediated hematopoietic stem cell expansion. Based on these postulations and evidences, a Hemgn knockout mouse model has been generated to study its function in normal and stress hematopoiesis. I confirmed the Hemgn expression in hematopoietic organs including bone marrow and spleen, as well as round spematids in testis. Hemgn is expressed in mouse hematopoietic stem cells and erythroid progenitor cells. Moreover, Hemgn was also found …
Role Of Iron In Ethanol Derived Hepatic Stress, Jesse A. Thornton
Role Of Iron In Ethanol Derived Hepatic Stress, Jesse A. Thornton
Theses, Dissertations and Capstones
Chronic alcohol abuse is the third leading cause of preventable death in the United States. Ethanol metabolism causes liver injury through alterations in hepatic metabolic state, redox status, and acetaldehyde adduct formations. Increased iron absorption is associated with chronic ethanol consumption and may play a role in ethanol induced oxidative stress. We tested the hypothesis that normal labile iron in the liver plays a role in ethanol related pathological stress, using C57/Bl6 mice pair-fed Lieber-DeCarli liquid ethanol diets for 11 and 22 weeks. Normal iron group mice received 55mg/kg iron as ferric citrate, whereas the low iron groups received 5mg/kg. …
Generation And Characterization Of Peptide Fusion Proteins, Brianna L. Probasco
Generation And Characterization Of Peptide Fusion Proteins, Brianna L. Probasco
Graduate School of Biomedical Sciences Theses and Dissertations
Pathogenic Th17 cells drive progression of many autoimmune diseases. Th17 cells develop from naïve T cells in the immune system after antigen-driven stimulation in a specific cytokine environment. Normally, T cells act to fight off infection, but when not properly controlled, they can cause disease. The cytokine interleukin-23 (IL-23) plays an essential role in the expansion of pathogenic Th17 cells. IL-23 is a heterodimeric protein, composed of a p19 alpha chain and a p40 beta chain. The p40 is also part of IL-12 and binds to the IL-12 receptor beta 1 (IL-12Rβ1) subunit. Thus, it follows that the IL-23 receptor …