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- CASPASE-12 (4)
- Inflammation (4)
- Autoimmunity (2)
- Epigenetics (2)
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- Lupus (2)
- Rheumatoid arthritis (2)
- A118G (1)
- African-American (1)
- Coronary artery disease (1)
- Drug efficacy (1)
- Health indicators (1)
- Immunogenetics (1)
- Interleukin-1 (1)
- Memory (1)
- Mitochondrial DNA copy number (1)
- Monozygotic twins (1)
- Opioid (1)
- Personalized medicine (1)
- Phenotypic variation (1)
- Polymorphism (1)
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- Receptor (1)
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Articles 1 - 9 of 9
Full-Text Articles in Genetic Phenomena
Clinical Relevance Of Μ-Opioid Receptor A118g Polymorphism In Demographically Variant Populations, Iryna Pokotylyuk, Srishti Kulshrestha, Zvi G. Loewy, Priyank Kumar
Clinical Relevance Of Μ-Opioid Receptor A118g Polymorphism In Demographically Variant Populations, Iryna Pokotylyuk, Srishti Kulshrestha, Zvi G. Loewy, Priyank Kumar
Touro College of Pharmacy (New York) Publications and Research
Use of opioids is essential in providing a broad and effective analgesic effect. Opioid dosing has to be monitored and controlled in order to manage pain and the corresponding side effects due to opioid treatment. A very common single nucleotide polymorphism (SNP) associated with the µ opioid receptor is A118G. A118G, located on exon 1 of the µ-opioid receptor gene (OPRM1), may alter how patients respond to opioid treatment. This polymorphism results in an exchange of adenine for guanine, which in turn leads to substitution of asparagine for the aspartic acid. In order to understand how individuals with the G …
Is It Time To Start Using Mitochondrial Dna Copy Number As An Indicator Of Health And Diseases?, Vasudeva G. Kamath
Is It Time To Start Using Mitochondrial Dna Copy Number As An Indicator Of Health And Diseases?, Vasudeva G. Kamath
Touro College of Osteopathic Medicine (Middletown) Publications and Research
The author discusses whether the medical community should seriously investigate the numerical relation of mitochondrial DNA copy number as a health indicator.
Caspase-12 And Lupus: The Curious Case Of The Dog That Didn’T Bark, Evan Hermel
Caspase-12 And Lupus: The Curious Case Of The Dog That Didn’T Bark, Evan Hermel
Faculty Publications & Research of the TUC College of Osteopathic Medicine
CASPASE-12 (CASP12) has an anti-inflammatory function during infection, and is a risk factor for sepsis in African-Americans (AA). To determine if CASP12 could be protective for systemic lupus erythematosus (SLE) in AA, we genotyped AA SLE patients and controls. We found that, at best, there was a weak association between CASP12 genotype with the absence of anti-dsDNA autoantibodies in SLE patients. No effect was seen upon serum interleukin-1 beta levels, nor was any other protective effect noted for the CASP12 genotype, whether upon association with SLE, or any of the 11 American College of Rheumatology classification criteria. We concluded that …
The Anti-Inflammatory Caspase-12 Gene Does Not Influence Sle Phenotype In African-Americans, Trista Fuchs, Jennifer A. Kelly, Emily Simon, Kathy L. Sivils, Evan Hermel
The Anti-Inflammatory Caspase-12 Gene Does Not Influence Sle Phenotype In African-Americans, Trista Fuchs, Jennifer A. Kelly, Emily Simon, Kathy L. Sivils, Evan Hermel
Faculty Publications & Research of the TUC College of Osteopathic Medicine
No abstract provided.
Caspase-12, Rheumatoid Arthritis, And The Dog That Didn’T Bark, Evan Hermel
Caspase-12, Rheumatoid Arthritis, And The Dog That Didn’T Bark, Evan Hermel
Faculty Publications & Research of the TUC College of Osteopathic Medicine
CASPASE-12 (CASP12) has an anti-inflammatory function during infection. To determine and if CASP12 could protect against inflammatory disease, we investigated the distribution of CASP12 alleles in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 homozygous patients had lower baseline joint narrowing and total disease scores. However, there was no significant difference for distribution of CASP12 genotypes between AA controls and patients with RA, or any other clinical criteria for this disease. CASP12 homozygosity appears to be, at best a subtle protective factor for some aspects of RA in AA patients. This raises an intriguing issue as to how this protein would …
Caspase-12 And Rheumatoid Arthritis In African-Americans, Laura Marshall, Mohammad Obaidullah, Trista Fuchs, Naomi S. Fineberg, Garland Brinkley, Ted R. Mikuls, Evan Hermel
Caspase-12 And Rheumatoid Arthritis In African-Americans, Laura Marshall, Mohammad Obaidullah, Trista Fuchs, Naomi S. Fineberg, Garland Brinkley, Ted R. Mikuls, Evan Hermel
Faculty Publications & Research of the TUC College of Osteopathic Medicine
CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal–Wallis non-parametric ANOVA with Mann–Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA …
Epigenetics: A Possible Mechanism Of Memory, Aliza Grossman Rubenstein
Epigenetics: A Possible Mechanism Of Memory, Aliza Grossman Rubenstein
The Science Journal of the Lander College of Arts and Sciences
The following is an excerpt from the introduction to this article: The mind-body connection has fascinated philosophers and scientists for centuries. How is it possible that consciousness arises from a lump of matter known as the brain? How does neurons’ firing affect choice and beliefs? How do the electrochemical properties of the brain allow for the memory of events long after they’ve occurred? One of the most studied of these areas is that of memory. Researchers seek to understand the biological basis behind memory and how that biology is affected in individuals suffering from memory disorders.
Epigenetics As An Explanation For Phenotypic Variation In Monozygotic Twins, Marina Pomerantseva
Epigenetics As An Explanation For Phenotypic Variation In Monozygotic Twins, Marina Pomerantseva
The Science Journal of the Lander College of Arts and Sciences
The following is the introduction of this article: Researchers often use twins as natural samples to test hypotheses regarding the contribution of genetic factors to different phenotypes, especially diseases. The classical method is comparing traits in identical, or monozygotic (MZ) twins to those of dizygotic (DZ) twins. This method has had a significant impact on our current understanding of etiologic factors in many diseases which do not follow simple Mendelian law (i.e. complex diseases), including schizophrenia, bipolar disease, and major depression.
Role Of Genetics In Prediction Of Coronary Artery Disease, Andrey Yuabov
Role Of Genetics In Prediction Of Coronary Artery Disease, Andrey Yuabov
The Science Journal of the Lander College of Arts and Sciences
The following is the introduction of this article: Coronary arteries disease (CAD) is a leading cause of death in United States and rest of the world. It mostly involves atherogenic formation within the walls of the coronary arteries, which in turn restricts the adequate perfusion to the heart muscle. This leads to myocardial infarction and sudden death. In the past few decades the theories of coronary arteries disease pathogenesis have changed. The facts reveal that the onset of the disease can develop as early as childhood. The degree of the disease gradually progresses in stages and it is regarded as …