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Digestive, Oral, and Skin Physiology Commons™

Open Access. Powered by Scholars. Published by Universities.®

2010

Articles 1 - 2 of 2

Full-Text Articles in Digestive, Oral, and Skin Physiology

Probiotic Therapy - Recruiting Old Friends To Fight New Foes, Roy D. Sleator Jun 2010

Probiotic Therapy - Recruiting Old Friends To Fight New Foes, Roy D. Sleator

Department of Biological Sciences Publications

Against a backdrop of increasing antibiotic resistance, and the emergence of new and evolving pathogens, clinicians are increasingly forced to consider alternative therapies - probiotics are one such alternative.

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Investigating The Role Of P311 In The Hypertrophic Scar, Jianglin Tan, Xu Peng, Gaoxing Luo, Bing Ma, Chuan Cao, Weifeng He, Shunzong Yuan, Shirong Li, John A. Wilkins, Jun Wu Apr 2010

Investigating The Role Of P311 In The Hypertrophic Scar, Jianglin Tan, Xu Peng, Gaoxing Luo, Bing Ma, Chuan Cao, Weifeng He, Shunzong Yuan, Shirong Li, John A. Wilkins, Jun Wu

MIIR Faculty Research

The mechanisms of hypertrophic scar formation are not fully understood. We previously screened the differentially expressed genes of human hypertrophic scar tissue and identified P311 gene as upregulated. As the activities of P311 in human fibroblast function are unknown, we examined the distribution of it and the effects of forced expression or silencing of expression of P311. P311 expression was detected in fibroblast-like cells from the hypertrophic scar of burn injury patients but not in peripheral blood mononuclear cells, bone marrow mesenchymal stem cells, epidermal cells or normal skin dermal cells. Transfection of fibroblasts with P311 gene stimulated the expression …

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