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Full-Text Articles in Digestive, Oral, and Skin Physiology
Interleukin 10 Restores Gastric Emptying, Electrical Activity, And Interstitial Cells Of Cajal Networks In Diabetic Mice, Anthony J. Bauer
Interleukin 10 Restores Gastric Emptying, Electrical Activity, And Interstitial Cells Of Cajal Networks In Diabetic Mice, Anthony J. Bauer
Anthony Bauer
Background and Aims—Gastroparesis is a complication of diabetes, characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and induces expression of heme oxygenase 1 (HO1) protein. We investigated whether IL10 administration could improve gastric emptying and reverse the associated cellular and electrical abnormalities in diabetic mice.
Methods—Non-obese diabetic mice with delayed gastric emptying were given either IL10 (0.1-1μg, twice/day) or vehicle (controls). Stomach tissues were isolated, and sharp microelectrode recordings were made of the electrical activity …