Circulatory and Respiratory Physiology Commons^™

Effect Of Charge On The Deposition Of Electrostatically Charged Inhalable Aerosol In Lung Model, Divey Saini, C. U. Yurteri, N. Grable, Robert A. Sims, Malay K. Mazumder

Journal of the Arkansas Academy of Science

Inhalable drugs are widely used for treating lung diseases such as asthma, emphysema, and cystic fibrosis. The aerosol particles in these inhalable drugs may be charged electrostatically. The deposition of these inhaled therapeutic aerosol particles in the different regions of the lung depends on the particle aerodynamic diameter, electrostatic charge distribution, particulate number density, breathing rate, aerodynamics of the lung, ambient temperature, and relative humidity (RH). The primary mechanisms for lung deposition of inhaled particles are impaction, gravitational settling, diffusion, interception, and electrostatic attraction. To simulate lung deposition, electrostatically charged aerosol particles are introduced through a throat section into a …

Search For Intracranial Aneurysm Susceptibility Gene(S) Using Finnish Families, Jane M. Olson, Sompong Vongpunsawad, Helena Kuivaniemi, Antti Ronkainen, Juha Hernesniemi, Markku Ryynã¤Nen, Lee-Lian Kim, Gerard Tromp

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cerebrovascular disease is the third leading cause of death in the United States, and about one-fourth of cerebrovascular deaths are attributed to ruptured intracranial aneurysms (IA). Epidemiological evidence suggests that IAs cluster in families, and are therefore probably genetic. Identification of individuals at risk for developing IAs by genetic tests will allow concentration of diagnostic imaging on high-risk individuals. We used model-free linkage analysis based on allele sharing with a two-stage design for a genome-wide scan to identify chromosomal regions that may harbor IA loci.

Methods

We previously estimated sibling relative risk in the Finnish population at between …

An Examination Of The Relationship Between Lung Function And Aerobic Capacity In People With Asthma., Pat Flanagan

Theses

The prevalence of asthma is rapidly increasing throughout the world. Many developed countries have reported a greater incidence and severity of asthma in both adults and children (Woolcock and Peat, 1997). Up to 90% of those diagnosed with asthma will experience some asthma symptoms during or after exercise. This condition is known as Exercise-Induced Asthma (EIA). The severity of the bout of EIA depends mainly on the type, intensity and duration of the exercise session. Environmental conditions, medication and possibly the level of fitness of the individual may also influence EIA (Storms and Joyner, 1999; Guill, 1996; Weiler, 1996).

The …