Open Access. Powered by Scholars. Published by Universities.®
Circulatory and Respiratory Physiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Angiogenesis (1)
- Blood vessels (1)
- Cell cycle and cell division (1)
- Cell cycle inhibitors (1)
- Cell migration (1)
-
- Endothelial cells (1)
- Exercise induced laryngeal obstruction (1)
- Gene expression (1)
- Heart (1)
- Heart failure (1)
- Medicine and Health Sciences, Anatomy, Cardiovascular System, Cells, Medical Sciences, Circulatory and Respiratory Physiology, Medical Biochemistry, Medical Cell Biology (1)
- Microarrays (1)
- Pre-med (1)
- Protein (1)
- Rehabilitation (1)
- Research (1)
- Respiratory (1)
- Therapeutic devices (1)
- Therapeutic exercise (1)
- Titin (1)
- Vocal cord dysfunction (1)
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Circulatory and Respiratory Physiology
Potential Role Of The Large Protein Titin In The Development Of Heart Failure, Mary M. Prickett
Potential Role Of The Large Protein Titin In The Development Of Heart Failure, Mary M. Prickett
Senior Theses
I will be exploring the impact of the large protein Titin on heart failure with a preserved ejection fraction (HFpEF). It was hypothesized that myocardial Titin plays a significant role in the progression of HFpEF through isoform, N2BA and N2B, changes. It was hypothesized that an increase in the quantity of N2B Titin, less compliant, and a decrease in N2BA Titin, more compliant, will be observed as HF progresses, contributing to an increase in passive stiffness involved in heart contraction. I will cover a detailed report on the role of Titin in HFpEF and propose research methods to explore further.
Exercise Induced Laryngeal Obstruction In A Collegiate Runner: A Case Report Of A Novel Therapy, Cody Inskeep, Todd Olin, Robert Arthur
Exercise Induced Laryngeal Obstruction In A Collegiate Runner: A Case Report Of A Novel Therapy, Cody Inskeep, Todd Olin, Robert Arthur
Clinical Practice in Athletic Training
A 23-year-old male Division I distance runner presented with several years of exertional stridor (high-pitched inspiratory noise caused by airflow obstruction), previously diagnosed as exercised-induced laryngeal obstruction (EILO), a condition formerly known as vocal cord dysfunction and exercised-induced paradoxical vocal fold motion. Over the course of roughly 3 years, the patient had previously failed conventional and invasive respiratory therapies for EILO including respiratory retraining, inspiratory muscle training, reflux suppression, allergy suppression, amitriptyline, performance psychology, and injection of botulinum toxin to the larynx. At a referral center that specializes in the treatment of EILO, the patient's diagnosis was confirmed through the …
Best Practices In Patellar Tendinopathy Management: An Evidence To Practice Review, Christopher J. Burcal, Adam B. Rosen, Tony Taylor, Mike Nicola
Best Practices In Patellar Tendinopathy Management: An Evidence To Practice Review, Christopher J. Burcal, Adam B. Rosen, Tony Taylor, Mike Nicola
Clinical Practice in Athletic Training
Patellar tendinopathy (PT) is a degenerative condition that is common in sporting populations due to the loads placed on the tendon during dynamic activity. PT often occurs in overtraining situations; however, it may also occur in conjunction with and/or worsen through poor biomechanics, persistent inflammation, and altered movement patterns. Although sports medicine practitioners have evidence to support the prevalence of this injury, we do not have a strong base of evidence surrounding the contributing factors and pathophysiology that lead the pain and disability reported in patients with PT. The purpose of this evidence to practice review was to summarize a …
Sparstolonin B Inhibits Pro-Angiogenic Functions And Blocks Cell Cycle Progression In Endothelial Cells, H. R. Bateman, Q. Liang, D. Fan, V. Rodriguez, Susan M. Lessner
Sparstolonin B Inhibits Pro-Angiogenic Functions And Blocks Cell Cycle Progression In Endothelial Cells, H. R. Bateman, Q. Liang, D. Fan, V. Rodriguez, Susan M. Lessner
Faculty Publications
Sparstolonin B (SsnB) is a novel bioactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. Angiogenesis, the process of new capillary formation from existing blood vessels, is dysregulated in many pathological disorders, including diabetic retinopathy, tumor growth, and atherosclerosis. In functional assays, SsnB inhibited endothelial cell tube formation (Matrigel method) and cell migration (Transwell method) in a dose-dependent manner. Microarray experiments with human umbilical vein endothelial cells (HUVECs) and human coronary artery endothelial cells (HCAECs) demonstrated differential expression of several hundred genes in response to SsnB exposure (916 and 356 …