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University of New England

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Full-Text Articles in Chemical and Pharmacologic Phenomena

Steroid Receptor Isoform Expression In Drosophila Nociceptor Neurons Is Required For Normal Dendritic Arbor And Sensitivity, Aidan L. Mcparland, Taylor L. Follansbee, Gwendolyn D. Vesenka, Alexandra E. Panaitiu, Geoffrey K. Ganter Oct 2015

Steroid Receptor Isoform Expression In Drosophila Nociceptor Neurons Is Required For Normal Dendritic Arbor And Sensitivity, Aidan L. Mcparland, Taylor L. Follansbee, Gwendolyn D. Vesenka, Alexandra E. Panaitiu, Geoffrey K. Ganter

Biology Student Publications

Steroid hormones organize many aspects of development, including that of the nervous system. Steroids also play neuromodulatory and other activational roles, including regulation of sensitivity to painful stimuli in mammals. In Drosophila, ecdysteroids are the only steroid hormones, and therefore the fly represents a simplified model system in which to explore mechanisms of steroid neuromodulation of nociception. In this report, we present evidence that ecdysteroids, acting through two isoforms of their nuclear ecdysone receptor (EcR), modulate sensitivity to noxious thermal and mechanical stimuli in the fly larva. We show that EcRA and EcRB1 are expressed by third instar larvae in …

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Effects Of Combined Opioids On Pain And Mood In Mammals, David J. Mokler, Richard H. Rech, Shannon L. Briggs Jan 2012

Effects Of Combined Opioids On Pain And Mood In Mammals, David J. Mokler, Richard H. Rech, Shannon L. Briggs

Biomedical Sciences Faculty Publications

The authors review the opioid literature for evidence of increased analgesia and reduced adverse side effects by combining opioid-receptor (MOR) agonists, kappa-opioid-recepter (KOR) agonists, and nonselective low-dose-opioid antagonists (LD-ANT). We tested fentanyl (MOR agonist) and spiradoline (KOR agonist), singly and combined, against somatic and visceral pain models. Combined agonists induced additive analgesia in somatic pain and synergistic analgesia in visceral pain. Other investigators report similar effects and reduced tolerance and dependence with combined MOR agonist and KOR agonist. LD-Ant added to either a MOR agonist or KOR agonist markedly enhanced analgesia of either agonist. In accordance with other place-condition (PC) …

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Diazepam, Pentobarbital, And Methaqualone Effects On Several Behaviors In The Rat And Antagonism By Ro 15-1788, David J. Mokler, Richard H. Rech Jan 1983

Diazepam, Pentobarbital, And Methaqualone Effects On Several Behaviors In The Rat And Antagonism By Ro 15-1788, David J. Mokler, Richard H. Rech

Biomedical Sciences Faculty Publications

The sedative hypnotics may exert their effects through a number of different mechanisms. Diazepam interacts with a specific receptor linked to a GABA receptor and a CL ionophore (Skolnick and Paul, 1981) and enhances the binding affinity of the GABA receptor for its ligand. Barbiturates may act at an additional receptor linked to this complex (Olsen, 1981). The sites of action of methaqualone have yet to be defined. Recently Hunkeler et al. (1981) synthesized a new class of compounds, the imidazodiazepines, the prototype being Ro 15-1788. They showed that Ro 15-1788 inhibits 3H-Diazepam binding to brain synaptosomes, reverses diazepam-induced protection …

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