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Full-Text Articles in Chemical and Pharmacologic Phenomena
Population Pharmacokinetics Of Intravenous Colistin In Pediatrics (Poppicop Study), Noppadol Wacharachaisurapol
Population Pharmacokinetics Of Intravenous Colistin In Pediatrics (Poppicop Study), Noppadol Wacharachaisurapol
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Colistin use in pediatrics is surging in line with the increase of multidrug-resistant Gram-negative bacteria (MDR-GNB). However, the appropriate dose is uncertain owing to the lack of pharmacokinetics data. In this study, we aimed to characterize the pharmacokinetic parameters of colistin in pediatric patients, identify the factors influencing the pharmacokinetic parameters, and propose optimal dosage regimens. Methods: A prospective, multicenter, population pharmacokinetic (PPK) study was conducted. Serial blood samples were obtained from patients after receiving the standard colistin recommended dose of 5 mg of colistin base activity (CBA)/kg/day. Plasma colistin concentrations were measured. Data were pooled from this study …
Effects Of Topical Application Of Combined Phyllanthus Emblica Linn. And Simvastatin On Diabetic Wound In Mice, Tingting Liao
Effects Of Topical Application Of Combined Phyllanthus Emblica Linn. And Simvastatin On Diabetic Wound In Mice, Tingting Liao
Chulalongkorn University Theses and Dissertations (Chula ETD)
Non-healing diabetic foot ulcers are the most common cause of lower extremity amputation. Drug combination treatment is the most recent emerging strategy in local treatment of diabetic wound. This study aimed to find out the combined effects and underlying mechanisms of combined Phyllanthus emblica Linn. (PE) and simvastatin (SIM) on diabetic wound in mice. Male BALB/C mice were divided into five groups: control group (CON+Vehicle), diabetic wounded group (DM+Vehicle, streptozotocin 45 mg/kg. i.p. daily for 5 days), diabetic wounded groups with daily treatment of 100%PE cream, 5%SIM cream, and 100%PE+5%SIM combined cream, w/v, for 4 days, 7 days and 14 …