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Articles 1441 - 1444 of 1444
Full-Text Articles in Medical Sciences
Novel Orally Active Hydrogen Sulfide-Releasing Compound, Sg1002, Improves Left Ventricular Function And Survival In A Murine Model Of Ischemic Cardiomyopathy, Bharat Balan
Theses and Dissertations
Hydrogen sulfide (H2S) is a gasotransmitter that has shown cardioprotective effects in the setting of myocardial injury such as acute myocardial infarction (MI) and pressure overload-induced heart failure. However, there are shortcomings in precision and control release from the use of traditional formulations of H2S in the form of inorganic salts. In this thesis, we sought to determine if the novel, orally active, slow-releasing H2S-compound SG1002 plays a role in attenuating MI-induced left ventricular (LV) dysfunction and adverse remodeling. We also evaluated the effect of SG1002 on changes in ECG parameters such as QT …
Mathematical Models Of The Inflammatory Response In The Lungs, Sarah B. Minucci
Mathematical Models Of The Inflammatory Response In The Lungs, Sarah B. Minucci
Theses and Dissertations
Inflammation in the lungs can occur for many reasons, from bacterial infections to stretch by mechanical ventilation. In this work we compare and contrast various mathematical models for lung injuries in the categories of acute infection, latent versus active infection, and particulate inhalation. We focus on systems of ordinary differential equations (ODEs), agent-based models (ABMs), and Boolean networks. Each type of model provides different insight into the immune response to damage in the lungs. This knowledge includes a better understanding of the complex dynamics of immune cells, proteins, and cytokines, recommendations for treatment with antibiotics, and a foundation for more …
Heme Oxygenase 1 Expression After Traumatic Brain Injury And Effect Of Pharmacological Manipulation On Functional Recovery., Nicholas H. Russell
Heme Oxygenase 1 Expression After Traumatic Brain Injury And Effect Of Pharmacological Manipulation On Functional Recovery., Nicholas H. Russell
Theses and Dissertations
Traumatic Brain Injury (TBI) is an increasingly diagnosed constellation of injuries derived from acute mechanical trauma to the brain. With the rise of advanced neuroimaging techniques recent focus has oriented primarily towards the mild-moderate range of TBI which previously was missed diagnostically. Characteristically, these advances have shown increasing areas of micro-hemorrhage in susceptible areas of the brain and to date there are no treatment modalities targeting micro-hemorrhages or their sequelae. This dissertation explores the effects of the resulting heme processing response in the days following injury with a particular focus on inducing early heme clearance from the parenchyma using a …
Retrospective Analysis Of Contact Sport Participation On Cognitive Function In Healthy Athletes, Lisa C. Martinez
Retrospective Analysis Of Contact Sport Participation On Cognitive Function In Healthy Athletes, Lisa C. Martinez
Cal Poly Humboldt theses and projects
This study explored the effects of contact and limited contact sport participation on neurocognitive function in non-concussed collegiate and adolescent athletes over time. Athletes participating in contact and limited contact sports have an increased risk of sustaining neurocognitive injuries, known as subconcussive blows, compared to non-contact sport athletes. We hypothesized that athletes participating in contact and limited contact sports, would exhibit a deficit in neurocognitive function following multiple seasons of play when compared to athletes participating in non-contact sports. Using a mixed repeated measures MANOVA statistical design, we analyzed computerized neurocognitive baseline ImPACT composite scores (verbal memory, visual memory, visual …