Open Access. Powered by Scholars. Published by Universities.®

Medical Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2002

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 181 - 199 of 199

Full-Text Articles in Medical Sciences

Disease Management And Liability In The Human Genome Era, Larry I. Palmer Jan 2002

Disease Management And Liability In The Human Genome Era, Larry I. Palmer

Faculty Publications

No abstract provided.

Go to article

Role Of Bcl-2 Family Members In Caspase-Independent Apoptosis Due To Chlamydia Infection, Jean-Luc Perfettini, John C. Reed, Nicole Israel, Jean-Claude Martinou, Alice Dautry-Varsat, David M. Ojcius Jan 2002

Role Of Bcl-2 Family Members In Caspase-Independent Apoptosis Due To Chlamydia Infection, Jean-Luc Perfettini, John C. Reed, Nicole Israel, Jean-Claude Martinou, Alice Dautry-Varsat, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Infection with an obligate intracellular bacterium, the Chlamydia trachomatis lymphogranuloma venereum (LGV/L2) strain or the guinea pig inclusion conjunctivitis serovar of Chlamydia psittaci, leads to apoptosis of host cells. The apoptosis is not affected by a broad-spectrum caspase inhibitor, and caspase-3 is not activated in infected cells, suggesting that apoptosis mediated by these two strains of Chlamydia is independent of known caspases. Overexpression of the proapoptotic Bcl-2 family member, Bax, was previously shown to induce caspase-independent apoptosis, and we find that Bax is activated and translocates from the cytosol to the mitochondria in C. psittaci-infected cells. C. psittaci-induced apoptosis is …

Go to article

Internet Usage Among Medical Doctors In Malaysia, Surendran Jaganathan Jan 2002

Internet Usage Among Medical Doctors In Malaysia, Surendran Jaganathan

Student Works (2000-2009)

In Malaysia, there were 20,000 Internet subscribers in 1996, 1.5 Million in 2000 and it is predicted to reach 4.5 Million in 2004. Malaysia is experiencing an explosive growth of Internet users. There is also a growing importance of "e -health businesses" as shown in the existing 20,000 healthcare sites currently online with an additional 1,500 sites being added every month. This translates to increasing healthcare site users for instance in America alone, out of 11 o million Internet users, 70 million searched the Web for health information. For healthcare consumers worldwide, the Internet has now become a tool for …

Go to article

Nitric Oxide Ii: Therapeutic Uses And Clinical Applications, Ayşe Baysal Jan 2002

Nitric Oxide Ii: Therapeutic Uses And Clinical Applications, Ayşe Baysal

Turkish Journal of Medical Sciences

Nitric oxide is a biological mediator in human organisms which plays important roles in tissue and organ hemostasis. Recent advances in the therapeutic uses of inhaled nitric oxide in lung diseases and other pathologic states urges the efficient and appropriate use of nitric oxide in hospitals. This study is a literature search based on a keyword search and the abstracts in English in Medline. The therapeutic indications for inhaled nitric oxide and various clinical applications are summarized. Subsequently, adverse effects and toxicity for inhaled nitric oxide and contraindications for its use are discussed.

Go to article

Nosocomial Fungal Infections In A Teaching Hospital In Turkey: Identification Of The Pathogens And Their Antifungal Susceptibility Patterns, Duygu Findik, İnci̇ Tuncer Jan 2002

Nosocomial Fungal Infections In A Teaching Hospital In Turkey: Identification Of The Pathogens And Their Antifungal Susceptibility Patterns, Duygu Findik, İnci̇ Tuncer

Turkish Journal of Medical Sciences

From January 1999 through April 2000, 208 Candida strains were obtained from hospitalized patients with nosocomial infection. Most of the species were isolated from urine (77.8%) followed by oropharynx (8.2%), blood stream (6.1%), drain (6.1%), peritoneum (0.9%) and cerebrospinal fluid specimens (0.9%). The distribution of the species obtained was Candida albicans (75.4%), C. glabrata (8.2%), C. tropicalis (4.8%), C. kefyr (3.4%), C. parapsilosis (2.5%), C. lusitaniae (1.9%), C. famata (1.4%), C. krusei (1.4%), and C. guilliermondii (1%). The antifungal susceptibility of the isolates to 5-fluorocytosine (5FCU), amphotericin B (AMP), nystatin (NYS), econazole (ECO), miconazole (MIC) and ketoconazole (KET) was tested …

Go to article

Evaluation Of The Patients With Acute Intoxication, Muhammet Güven, Murat Sungur, Fati̇h Tanriverdi̇, Bülent Eser, Zeynep Kekeç Jan 2002

Evaluation Of The Patients With Acute Intoxication, Muhammet Güven, Murat Sungur, Fati̇h Tanriverdi̇, Bülent Eser, Zeynep Kekeç

Turkish Journal of Medical Sciences

Objective: We evaluated the patients who were hospitalized for acute intoxications. We report the etiologies of intoxications, mortality rate, and the outcomes of treatment modalities. Materials and Methods: Data is given of patients who were hospitalized in the Intensive Care Unit of Erciyes University Medical Faculty from January 1, 1993 to December 31, 1999. The total number of patients followed in the Medical Intensive Care Unit during this period were 3500 and 272 (7.8%) of them were acute intoxications. One hundred and six patients were male (mean age; 31±18 years) and 166 were female (mean age; 24±15 years). Results: Insecticides …

Go to article

Prenatal Diagnosis Of Thanatophoric Dysplasia In Second Trimester, Hali̇l Aslan, Volkan Ülker, Necla Ülker, Nesli̇han Yerebasmaz, Cemal Ark Jan 2002

Prenatal Diagnosis Of Thanatophoric Dysplasia In Second Trimester, Hali̇l Aslan, Volkan Ülker, Necla Ülker, Nesli̇han Yerebasmaz, Cemal Ark

Turkish Journal of Medical Sciences

LAN Volkan ÜLKER Necla ÜLKER Neslihan YEREBASMAZ Cemal ARK Department of Perinatology, SSK Bakırköy Maternity and Children Hospital, İstanbul, Turkey

Go to article

Maxillary Sinus Aplasia, Murat Baykara, Nuri̇ Erdoğan, Mustafa Öztürk, Mustafa Erkan Jan 2002

Maxillary Sinus Aplasia, Murat Baykara, Nuri̇ Erdoğan, Mustafa Öztürk, Mustafa Erkan

Turkish Journal of Medical Sciences

YKARA^1 Nuri ERDOĞAN^1 Mustafa ÖZTÜRK^1 Mustafa ERKAN^2 Departments of ^1Radiology, ^2Otorhinolaryngology, Faculty of Medicine, Erciyes University, Kayseri - Turkey

Go to article

The Effects Of Fenthion On Lipid Peroxidation And Some Liver Enzymes: The Possible Protective Role Of Vitamins E And C, İrfan Altuntaş, Namik Deli̇baş Jan 2002

The Effects Of Fenthion On Lipid Peroxidation And Some Liver Enzymes: The Possible Protective Role Of Vitamins E And C, İrfan Altuntaş, Namik Deli̇baş

Turkish Journal of Medical Sciences

The effects of fenthion on the serum activities of cholinesterase (ChE), enzymes concerning liver damage and lipid peroxidation (LPO), and the ameliorating effects of a combination of vitamins E and C against fenthion toxicity were investigated. The results of the in vivo experiment showed that fenthion caused a significant increase in LPO and the activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and lactate dehydrogenase (LDH), and a significant decrease in the activities of ChE and alanine aminotransferase (ALT). In addition, treatment with a combination of vitamins E and C led to a significant decrease in LPO and …

Go to article

Age And Gender Associated Changes In Cystatin C And \Beta 2 -Microglobulin, Zuhal Parildar, Ceyda Gülter, Sara Habi̇f, Işil Mutaf, Nevbahar Turgan, Di̇lek Özmen, Oya Bayindir Jan 2002

Age And Gender Associated Changes In Cystatin C And \Beta 2 -Microglobulin, Zuhal Parildar, Ceyda Gülter, Sara Habi̇f, Işil Mutaf, Nevbahar Turgan, Di̇lek Özmen, Oya Bayindir

Turkish Journal of Medical Sciences

Assessment of renal function in clinical medicine is of great importance. Various studies report that cystatin C (cysC) and \beta 2 -microglobulin are valuable markers of renal function. In this study, serum cysC and \beta 2 -microglobulin were measured in parallel with serum creatinine in a healthy population, and the characteristics of the relationship of cysC and \beta 2 -microglobulin to age and gender were compared. Serum creatinine, cysC and b2-microglobulin were measured in 119 (86 female; 33 male, 6 to 69 years old) healthy subjects. They were divided into five different age groups: group 1 (6-15 years, n = …

Go to article

Determination Of Polydispersity Of A Human Colonic Mucus Glycoprotein Using Rate-Zonal Centrifugation And Laser Light-Scattering, Nurten Aksoy, John K. Sheehan Jan 2002

Determination Of Polydispersity Of A Human Colonic Mucus Glycoprotein Using Rate-Zonal Centrifugation And Laser Light-Scattering, Nurten Aksoy, John K. Sheehan

Turkish Journal of Medical Sciences

The colonic epithelium is coated by a visco-elastic gel, mucus that lubricates and protects the mucosa from the external environment. Mucus glycoproteins (mucins, MUCs) are major macromolecular components with MUC2 representing the major gel-forming secretory mucin. Previously we purified MUC2 from a cell culture environment with either three rounds of isopicnic centrifugation or gel filtration chromatography followed by a single round of centrifugation. In the present work, using rate-zonal centrifugation in a gradient of guanidinium chloride we fractionated this purified MUC2 and its subunits. Analyses of the fractions showed that the unreduced MUC2 molecules are quite large and polydisperse in …

Go to article

A Comparative Study Of The Clinical Aspects And Relationship Between Fractures Of Mandibular Angle And The Presence Of A Lower Third Molar, Mehmet Yaltirik, Cem Rüştü Tanyel, Bülent Kati̇poğlu Jan 2002

A Comparative Study Of The Clinical Aspects And Relationship Between Fractures Of Mandibular Angle And The Presence Of A Lower Third Molar, Mehmet Yaltirik, Cem Rüştü Tanyel, Bülent Kati̇poğlu

Turkish Journal of Medical Sciences

Several authors have reported that the presence of teeth may be one of the determinants of mandibular fractures. Fracture of the jaw plays an important role in the practice of the oral surgeon. A number of factors contribute to the strength of the mandible. These include presence of active and strong musculature, the shape and thickness of the bone, and the presence or absence of teeth. The Deparment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, managed 100 patients with mandibular factures between 1991 and 1999. The male to female ratio was 5.25/1 and the majority of patients …

Go to article

Hellp! S.O.S. Call Of A Mother, Serpi̇l Demi̇rci̇, Vedat Ali̇ Yürekli̇ Jan 2002

Hellp! S.O.S. Call Of A Mother, Serpi̇l Demi̇rci̇, Vedat Ali̇ Yürekli̇

Turkish Journal of Medical Sciences

EMİRCİ Vedat Ali YÜREKLİ Department of Neurology, Faculty of Medicine, Süleyman Demirel University, Isparta - Turkey

Go to article

Distribution Of Different Fibronectin Isoforms In The Extracellular Matrices Of Human Term Placenta, Ayşe Yasemi̇n Demi̇r Weusten Jan 2002

Distribution Of Different Fibronectin Isoforms In The Extracellular Matrices Of Human Term Placenta, Ayşe Yasemi̇n Demi̇r Weusten

Turkish Journal of Medical Sciences

Fibronectins are considered to be molecules that play important roles in cell migration and cell differentiation. Fibronectin molecules are thought to influence the differentiation of trophoblasts and the adhesion of these cells to maternal tissues. The aim of the present study was to analyze the distribution of fibronectin isoforms and to evaluate the differences between matrix-type fibrinoids, and other types of matrices produced by both maternal and fetal tissues. Tissue samples were collected from different sites of human term placentas. By using immunohistochemistry, the expression of fibronectin isoforms was determined and they were demonstrated by SDS-PAGE and Western blotting methods. …

Go to article

Bile Duct Response To Repeated Cerulein Induced Pancreatitis In The Rat, Ali̇ Menteş, Hasan Aydede, Ümi̇t Bayol, Funda Yilmaz Jan 2002

Bile Duct Response To Repeated Cerulein Induced Pancreatitis In The Rat, Ali̇ Menteş, Hasan Aydede, Ümi̇t Bayol, Funda Yilmaz

Turkish Journal of Medical Sciences

The typical morphology of common bile duct strictures in chronic pancreatitis suggests a pathogenesis not of encasement, but of mural changes in the common bile duct. Cerulein, 20 µg/kg was administered to male Wistar rats in four subcutaneous doses, hourly for 3 h, and was recorded as one application. Group A served as controls and received subcutaneous saline. Group B1 received one application of Cerulein and was sacrificed after 24 h. Group B2 was similar to B1, but was sacrificed two weeks later. Group B3 was given two applications of Cerulein with an interval of two weeks and was sacrificed …

Go to article

Maternal Serum 25-Hydroxycholecalciferol Levels In The Third Trimester Of Pregnancy, Şi̇nasi̇ Özsoylu Jan 2002

Maternal Serum 25-Hydroxycholecalciferol Levels In The Third Trimester Of Pregnancy, Şi̇nasi̇ Özsoylu

Turkish Journal of Medical Sciences

No abstract provided.

Go to article

Faculty Publications 2001, Lsu Health Sciences Center New Orleans Jan 2002

Faculty Publications 2001, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 706 publications.

Go to article

Staphylococcus Aureus Agr And Sara Functions Are Required For Invasive Infection But Not Inflammatory Responses In The Lung, Geoffrey Heyer, Shahryar Saba, Robert Adamo, William Rush, Grace Soong, Ambrose Cheung, Alice Prince Jan 2002

Staphylococcus Aureus Agr And Sara Functions Are Required For Invasive Infection But Not Inflammatory Responses In The Lung, Geoffrey Heyer, Shahryar Saba, Robert Adamo, William Rush, Grace Soong, Ambrose Cheung, Alice Prince

Dartmouth Scholarship

Staphylococcus aureus strains lacking agr- and sarA-dependent gene products or specific MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesins were compared for the ability to activate inflammatory responses in the lung. The mutants were evaluated for virulence in a mouse model of pneumonia and by quantifying their ability to stimulate interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in respiratory epithelial cells. In a neonatal mouse, only strains with intact agr and sarA loci were consistently associated with invasive, fatal pulmonary infection (P < 0.001) and sarA was specifically required to cause bacteremia (P < 0.001). The agr and/or sarA mutants were, nonetheless, fully capable of producing pneumonia and were as proficient as the wild-type strain in stimulating epithelial IL-8 expression, a polymorphonuclear leukocyte chemokine, in airway cells. In contrast, agr and especially sarA mutants induced less epithelial GM-CSF expression, and MSCRAMM mutants lacking fibronectin binding proteins or clumping factor A, a ligand for fibrinogen, were unable to stimulate epithelial GM-CSF production. The ability to induce IL-8 expression was independent of the adherence properties of intact bacteria, indicating that shed and/or secreted bacterial components activate epithelial responses. While conserved staphylococcal components such as peptidoglycan are sufficient to evoke inflammation and cause pneumonia, the agr and sarA loci of S. aureus are critical for the coordination of invasive infection of the lungs.

Go to article

Transcriptional Interference By Independently Regulated Genes Occurs In Any Relative Arrangement Of The Genes And Is Influenced By Chromosomal Integration Position, Susan K. Eszterhas, Eric E. Bouhassira, David I. K. Martin, Steven Fiering Jan 2002

Transcriptional Interference By Independently Regulated Genes Occurs In Any Relative Arrangement Of The Genes And Is Influenced By Chromosomal Integration Position, Susan K. Eszterhas, Eric E. Bouhassira, David I. K. Martin, Steven Fiering

Dartmouth Scholarship

Transcriptional interference is the influence, generally suppressive, of one active transcriptional unit on another unit linked in cis. Its wide occurrence in experimental systems suggests that it may also influence transcription in many loci, but little is known about its precise nature or underlying mechanisms. Here we report a study of the interaction of two nearly identical transcription units juxtaposed in various arrangements. Each reporter gene in the constructs has its own promoter and enhancer and a strong polyadenylation signal. We used recombinase-mediated cassette exchange (RMCE) to insert the constructs into previously tagged genomic sites in cultured cells. This …

Go to article

First Prev