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Articles 31 - 32 of 32
Full-Text Articles in Medical Sciences
Atlas-Based Attenuation Correction For Pet/Mri, John Christian Patrick
Atlas-Based Attenuation Correction For Pet/Mri, John Christian Patrick
Electronic Thesis and Dissertation Repository
Attenuation correction (AC) in PET/MRI is difficult as there is no clear relationship between MR signal and 511 keV attenuation coefficients (μ). One strategy is to align a pre-defined atlas of μ to the PET/MRI for AC. However, atlas design may influence quantitative accuracy of AC. In this thesis we compare 3 atlas design strategies and evaluate their performance in an oncology patient population. The 3 strategies were: correction with BMI-dependent atlases; gender-dependent atlases, and a gender- and sex-independent atlas. Patients were imaged with FDG PET/CT and 3T MRI. The atlases were created and then used for PET AC of …
Investigating Adenosine’S Role In Controlling The Cerebral Metabolic Rate Of Oxygen Following Hypoxia-Ischemia, Mustafa Ridha
Investigating Adenosine’S Role In Controlling The Cerebral Metabolic Rate Of Oxygen Following Hypoxia-Ischemia, Mustafa Ridha
Electronic Thesis and Dissertation Repository
The cerebral metabolic rate of oxygen (CMRO2) has been shown to be an early indicator of hypoxia-ischemia (HI); however, the mechanisms controlling post-HI CMRO2 are not clear. One potential mechanism is the activation of the adenosine A1 receptor due to increased adenosine concentrations during the insult. The present study investigated if the specific adenosine A1 antagonist, DPCPX, would reduce the typical reduction in CMRO2 and electrical cortical activity following HI. Measurements of CMRO2 and electrical cortical activity were obtained on piglets by near-infrared spectroscopy (NIRS) and amplitude-integrated electroencephalography (aEEG), respectively. The post-HI measurements of CMRO2 and mean aEEG background voltage …