Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Biochemistry (155)
- Medical Molecular Biology (117)
- Life Sciences (17)
- Biochemistry (14)
- Biochemistry, Biophysics, and Structural Biology (14)
-
- Molecular Biology (14)
- Medical Microbiology (12)
- Medical Cell Biology (10)
- Genetic Phenomena (9)
- Medical Specialties (8)
- Medical Pharmacology (6)
- Diseases (5)
- Neurosciences (5)
- Chemicals and Drugs (4)
- Medical Genetics (4)
- Biological Phenomena, Cell Phenomena, and Immunity (3)
- Chemical and Pharmacologic Phenomena (3)
- Medical Immunology (3)
- Oncology (3)
- Genetic Structures (2)
- Genetics and Genomics (2)
- Medical Neurobiology (2)
- Medical Pathology (2)
- Microbiology (2)
- Neurology (2)
- Translational Medical Research (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Bacteriology (1)
- Keyword
-
- Humans (48)
- Animals (35)
- Department of Biochemistry and Molecular Biology (30)
- Thomas Jefferson University (21)
- RNA (17)
-
- Models (16)
- Molecular (16)
- Mice (13)
- Mutation (13)
- Transfer (13)
- Mitochondria (12)
- Models, Molecular (12)
- Receptors (12)
- Ribosomes (11)
- DNA (10)
- Escherichia coli (9)
- Protein Binding (9)
- RNA, Transfer (9)
- Protein Conformation (8)
- Apoptosis (7)
- Kinetics (7)
- Substrate Specificity (7)
- Catalytic Domain (6)
- Cell Line (6)
- Drosophila melanogaster (6)
- Endodeoxyribonucleases (6)
- Genetic (6)
- HEK293 Cells (6)
- Protein Structure (6)
- Structure-Activity Relationship (6)
- Publication Year
- File Type
Articles 211 - 211 of 211
Full-Text Articles in Medical Sciences
Anti-Human Immunodeficiency Virus (Hiv) Activities Of Halogenated Gomisin J Derivatives, New Nonnucleoside Inhibitors Of Hiv Type 1 Reverse Transcriptase, Toshiaki Fujihashi, Hiroto Hara, Toshiya Sakata, Kazuya Mori, Hirotaka Higuchi, Akio Tanaka, Hideko Kaji, Akira Kaji
Anti-Human Immunodeficiency Virus (Hiv) Activities Of Halogenated Gomisin J Derivatives, New Nonnucleoside Inhibitors Of Hiv Type 1 Reverse Transcriptase, Toshiaki Fujihashi, Hiroto Hara, Toshiya Sakata, Kazuya Mori, Hirotaka Higuchi, Akio Tanaka, Hideko Kaji, Akira Kaji
Department of Biochemistry and Molecular Biology Faculty Papers
Halogenated gomisin J (a derivative of lignan compound), represented by the bromine derivative 1506 [(6R, 7S, S-biar)-4,9-dibromo-3,10-dihydroxy-1,2,11,12-tetramethoxy-6, 7-dimethyl-5,6,7,8- tetrahydrodibenzo[a,c]cyclo-octene], was found to be a potent inhibitor of the cytopathic effects of human immunodeficiency virus type 1 (HIV-1) on MT-4 human T cells (50% effective dose, 0.1 to 0.5 microM). Gomisin J derivatives were active in preventing p24 production from acutely HIV-1-infected H9 cells. The selective indices (toxic dose/effective dose) of these compounds were as high as > 300 in some systems. 1506 was active against 3'-azido-3'-deoxythymidine-resistant HIV-1 and acted synergistically with AZT and 2',3'-ddC. 1506 inhibited HIV-1 reverse transcriptase (RT) in …