Medical Sciences Commons^™

The Integrative Role Of Melatonin In Psychiatric Disorders: A Systematic Review Of Evidence From Circadian Biology, Lifestyle Medicine, And Psychoneuroimmunology, Ho Bao Chau Le, Kollawat Somsri, Thansita Bhunyakarnjanarat, Nattiya Hirankarn, Asada Leelahavanichkul

BioMedicine

Melatonin, a hormone produced by the pineal gland, is known for regulating circadian rhythms and has emerging therapeutic potential in psychiatric disorders. This systematic review examines evidence from clinical and preclinical studies to assess melatonin’s efficacy in the following conditions: depression, anxiety, bipolar disorder, and schizophrenia. Beyond its role in circadian regulation, melatonin exhibits antioxidative, anti-inflammatory, and immunomodulatory properties, which intersect with nutrition, lifestyle medicine, and psychoneuroimmunology (PNI).

The review finds that melatonin improves sleep quality, restores circadian balance, and modulates stress-related neuroimmune pathways. It also supports neuroplasticity and reduces oxidative stress, contributing to resilience against psychosocial and environmental stressors. …

From Rhythm To Resilience: The Interplay Of Circadian Rhythm, Melatonin, Lifestyle, Nutrition In Psychoneuroimmunology (Pni), Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Emerging evidence reveals that circadian rhythm, melatonin signaling, nutrition, and inflammation are intricately intertwined in shaping both mental and physical health. Circadian disruptions and lifestyle imbalances contribute to neuroinflammation, mood dysregulation, and cardiometabolic dysfunction, as seen in attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), metabolic syndrome,and cardiovascular diseases. This special issue highlights interdisciplinary research that integrates circadian biology, nutrition, and psychoneuroimmunology (PNI) toward personalized and preventive psychiatry. Featured studies explore circadian and melatonin mechanisms in ADHD and MDD, the therapeutic and prophylactic potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs), the neuroprotective potentical of paeoniflorin, and the role of extracellular …

Covered Stent Salvage For Iatrogenic Vertebral Artery Injury In Traumatic Cervical Spine Injury: A Case Report And Literature Review, Tzu-Hao Yen, Wei-Liang Chen, Ying-Lin Tseng, You-Pen Chiu, Hui-Ru Ji, Jeng-Hung Guo, Cheng-Di Chiu

BioMedicine

We report the case of a 70-year-old woman who sustained complex traumatic injuries in a motor vehicle accident, including cervical spine fractures and a high suspicion of traumatic vertebral artery injury (VAI). Initial digital subtraction angiography (DSA) revealed no evidence of vertebral artery (VA) involvement. She subsequently underwent anterior cervical discectomy and fusion (ACDF); however, an iatrogenic injury to the right VA occurred intraoperatively, necessitating emergent endovascular stenting for vascular repair. This case underscores the importance of comprehensive preoperative imaging, intraoperative vigilance, and coordinated multidisciplinary management in cervical spine trauma with potential vascular involvement.

Endoscopic Management Of Ureteric Stenosis And Calculi In Bilateral Incomplete Renal Duplication: A Case Study, Hafeez Sohaib Ahmad Warraich, Zirwa Younis, Jawairia Warraich, Khizra Warraich

BioMedicine

Renal duplication anomalies are one of the most frequent congenital urological conditions in the general population all over the world. Bilateral incomplete duplication, however, is exceedingly rare. We present a case of a 29-year-old female with bilateral incomplete duplex kidneys complicated by mid-ureteric stenosis on the right side and calculi in the left ureter and upper moiety of the left duplex kidney. Diagnostic imaging, including ultrasound, computed tomography (CT), and intravenous urography (IVU) confirmed these findings. The patient underwent successful bilateral ureteroscopy (URS) and left-sided retrograde intra-renal surgery (RIRS) for management of the above mentioned complications related to the duplex …

Effect Of Garcinol Against Arsenic-Induced Neurobehavioral Alterations And Liver And Kidney Dysfunction In Albino Mice, Abdulmohsen I. Algefare

BioMedicine

The extended exposure to inorganic arsenic is commonly linked to brain damage through oxidative and apoptotic processes. The compound known as Garcinol (GCL) has garnered significant interest due to its potential advantages for human well-being. Nevertheless, the ability of GCL to protect against toxicity generated by arsenic in the brain has not yet been investigated. Hence, our study aimed to examine the neuroprotective effectiveness of GCL in mitigating the detrimental impacts of sodium arsenite (SA) on behavioral patterns, the molecular mechanisms, apoptotic markers, and oxidative stress parameters in the brain, liver, and kidney of mice. The mice were categorized into …

Investigating The Association Between Hyperthyroidism And The Risk Of Herpes Zoster In A Cohort Study In Taiwan, Shih-Wei Lai, Yu-Hung Kuo, Kuan-Fu Liao

BioMedicine

Background: The aim of this cohort study was to investigate the association between hyperthyroidism and the likelihood of developing herpes zoster in Taiwan.

Methods: Using the National Health Insurance Research Database (NHIRD) in Taiwan, we selected individuals aged 20-84 who were newly diagnosed with hyperthyroidism between 2013 and 2020 as the hyperthyroidism group. These individuals were then matched with a control group without hyperthyroidism in a 1:1 propensity score matching for sex, age, and baseline comorbidities. The occurrence of herpes zoster was tracked in both groups until the end of the study period or until a diagnosis of herpes zoster …

An Investigation Into The Potent Anticancer, Antimicrobial, And Anti-Inflammatory Activities Of A Punica Granatum Nanoemulgel, Ahmad M Eid, Murad Abualhasan, Yara Khaliliya, Zeina Sinan, Aya Khaliliya

BioMedicine

Purpose: The objective of this study is to formulate a nanoemulgel using Punica granatum (P. granatum) seed oil and study the antibacterial, anticancer, and anti-inflammatory properties. Methods: The process to formulate a nanoemulsion from P. granatum seed oil involved using the self-nanoemulsifying technique, with Span 80 and Tween 80 serving as the emulsifying agents. Carbopol hydrogel was combined with the nanoemulsion to produce the nanoemulgel. The particle size, polydispersity index (PDI), rheological behavior, antibacterial, cytotoxic, and anti-inflammatory properties were subsequently examined.

Results: The nanoemulsion formulation with a PDI of 0.229 and a particle size of 189.44 nm was …

Metabolomics In Cancer Detection: A Review Of Techniques, Biomarkers, And Clinical Utility, Kavitha Liegelin Bernhardt, Janita R. T. Pinto

BioMedicine

Cancer poses a significant burden on global public health, contributing to high mortality rates worldwide. Ongoing diagnostic strategies have predominantly relied on imaging techniques, histopathological examination and molecular analyses which have limitations in sensitivity, and specificity. Early cancer detection is a pivotal determinant of successful treatment and patient survival rates. Metabolomic applications involve the comprehensive analysis of metabolites to understand the metabolic profile of an organism, tissue, or cell under different conditions such as lack of oxygen in tumors. The aim of this review is to provide an extensive approach of metabolomic applications in early cancer detection and to provide …

Russell’S Viper Envenomation: The Challenge Of Diagnosis, Jing-Hua Lin, Wang-Chou Sung, Jiunn-Wang Liao, Dong-Zong Hung

BioMedicine

Russell’s viper envenomation is rare in Taiwan, and its typical clinical presentations, including consumption coagulopathy, acute renal failure, haemolysis, and increased capillary permeability, have been reported in the literature as case reports or series. Here, we report a case with an atypical presentation, and suspected to be a Russell’s viper bite due to the distinct characteristics of the snake and some progressive clinical signs/symptoms. He returned to health successfully after the correct antivenom was administered, and envenomation was ultimately confirmed by venom detection in the patient’s serum and urine samples.

Neurenteric Cysts: A Neurosurgical Case Series And Treatment Perspectives, Defran Ercan, Walter Stummer, Maryam Khaleghi Ghadiri

BioMedicine

Neurenteric cysts (NC) are rare lesions of endodermal origin lined by mucin-secreting cuboidal or columnar epithelium of an intestinal or respiratory type. They occur more frequently spinally than cranially. From the radiological view, NC may be confused with other lesions of the central nervous system, like arachnoid or epidermoid cysts. However, due to advances in neuroimaging, there is an increasing trend in preoperative diagnosis of NC. We are reporting three cases of NC, each exhibiting markedly distinct symptoms and postoperative courses. The first patient, a 45year-old woman, had NC in the fourth ventricle. Although she underwent surgery, the lesion recurred …

A Staged-Olif Approach Can Minimize Construct Lengths In Adult Spinal Deformity- A Case Series And Literature Review, Guna Pratheep Kalanchiama, Alexander Shao-Rong Pang, Jacob Yoong-Leong Oh

BioMedicine

Background:

Adult Spinal Deformity (ASD) is one of the challenging conditions to treat for spine surgeons. One of the important dilemmas in the management of these patients is the decision on the number of levels of instrumentation and the overall length of the construct. OLIF has the advantage of providing a minimally invasive approach to address this complex pathology also allowing us to stage the procedure and thus help clinicians reassess if the patient requires an additional decompression, long fusion lengths, or need for osteotomies.

Aim:

Our study aims to evaluate the possibility of minimizing the construct length following a …

Cyclohexylamine, The Principal Metabolite Of Cyclamate, Contracts The Epididymal Vas Deferens Of Rats By Affecting Endogenous Catecholamine Release Via Postsynaptic Α1aand Presynaptic Α2-Adrenoceptors In A Calcium-Dependent Manner, Yuh-Fung Chen, Yu-Wen Wang, Huei-Yann Tsai

BioMedicine

Background: Cyclohexylamine (CHA) is a principal metabolite of cyclamate, which was once one of the most prominently consumed non-sugar sweeteners. Earlier studies suggested that long-term use of cyclamate might be carcinogenic and genotoxic; however, no consistent evidence supports an association between cyclamate and cancer risk. However, this issue remains interesting. Cyclamate can be metabolized to CHA by the intestinal bacteria in humans and some animals. Previous reports indicated CHA could induce atrophy of rat testes and affect rat fertility, as well as contract rat vas deferens. However, the contractile mechanisms of CHA on rat vas deferens remains poorly understood. This …

Nutraceutical Benefits And Neuro-Protective Potent Of Four Colored Peppers (Capsicum Annuum Var. Grossum), Ya-Chen Yang, Chih-Lung Lin, Mei-Chin Yin

BioMedicine

Background: Four colored peppers (Capsicum annuum var. grossum), orange, purple, yellow and red, are plant foods served as salad or stir-fry for meals in Taiwan and many countries.

Purpose: This study aimed to investigate the multiple nutraceutical properties of aqueous extracts prepared from colored peppers.

Methods: Vitamin C content and phytochemical profiles of these peppers were analyzed. In vitro effects of anti-oxidative, anti-a-amylase, anti-a-glucosidase, antilipase and anti-acetylcholinesterase (AchE) of pepper aqueous extracts at 0.25, 0.5 and 1 mg were evaluated. The neuronal protective potent of pepper aqueous extracts at 0.5 and 1 mg in high glucose treated nerve growth factor …

The Protective Role Of Astaxanthin Against Oxidative Stress And Inflammation In Peritoneal Dialysis Rats, Ratih Tri Kusuma Dewi, Bambang Purwanto, Brian Wasita, Vitri Widyaningsih

BioMedicine

Background: Prolonged exposure of peritoneal membrane to dialysate solution is known to cause fibrosis mediated by imbalanced inflammatory response and oxidative stress. In this context, proinflammatory cytokines including TGF-β and IL-1β, along with oxidative stress markers namely SOD and MDA, present in circulation, could serve as indicators of fibrosis. This phenomenon has the potential to interfere with the optimization of Chronic Kidney Disease (CKD) treatment. Other oral antioxidant supplements have been widely studied to prevent peritoneal damage, but investigations regarding Astaxanthin (AST) effect on fibrosis marked with proinflammatory cytokine are still limited.

Aims: This study aimed to investigate the protective …

Distal Femur Fractures: The Use Of A Fibular Strut Allograft With Dual Locking Plates Allows For Early Weight Bearing, Brian Rui Kye Chee, Chenghan Wu, Abhjeet Ashok Salunke, Yongsheng Chen

BioMedicine

Introduction: Distal femur fractures result in high morbidity and mortality - comparable to that of hip fractures. The commonly used surgical fixation techniques today, locked plating and intramedullary nailing, have shown high postoperative complication rates. Thus, many surgeons temporarily keep patients non-weight bearing in the early post-operative stage. Increased time to ambulation after surgery is known to increase systemic complications in patients. We aim to investigate if an augmented fixation technique involving the use of a fibular strut allograft with dual locking plates helps to allow early mobilization postoperatively without adverse outcomes.

Methods: Five geriatric patients (four female, one male) …

Acute Phantosmia As The First Manifestaton Of Brain Metastases In A Patient With Breast Cancer. Case Report, Georgios I. Papageorgiou, Nikolaos Skouteris

BioMedicine

Phantosmia belongs to the group of olfactory dysfunctions. It is more commonly described in psychiatric conditions and some cases of viral infections, but it has been also rarely described in cancer patients who develop primary or metastatic central nervous system tumors; the early identification of this symptom in this population is crucial, as it could lead to timely diagnosis and treatment through a multidisciplinary approach.

With the current report we present the case of a 60-year-old lady with metastatic breast cancer and without known preexisting brain metastases, who developed acute phantosmia without other neurological deficits; computed tomography of the brain …

Estimated Levels Of Glycated Albumin And C-Reactive Protein/Total Albumin Ratio Might Distinguish Prediabetics Among The Apparently Healthy People And Predict The Vulnerability For Development Of Steatohepatitis And Cardiac Risk., Rizk S. Sarhan, Raafat R Mohammed

BioMedicine

Background: Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-gram oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer

Aims: The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.

Methods: IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if /dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance …

Plasma Levels Of Mir-21b And Mir-146a Can Discriminate Rheumatoid Arthritis Diagnosis And Severity., Rizk S. Sarhan, Amr M El-Hammady, Yasmin M Marei, Sania K Elwia, Doaa M Ismail, Emtethal As Ahmed

BioMedicine

Objectives: This study tried to examine the ability of the estimated plasma gene-expression levels (PGEL) of microRNA (miR)-146a and miR-21b to distinguish patients with early rheumatoid arthritis (RA) out of arthritis patients who did not fulfill the diagnostic spectrum of either RA or osteoarthritis (OA); the diagnostic Gray-Zone (GZ).

Patients & Methods: Enrolled patients underwent full diagnostic workup and were categorized as highseropositive and fulfilled the diagnostic spectrum for RA (RA-group), seronegative and fulfilling the diagnostic spectrum of OA (OA-group) and low-seropositive or seronegative patients who did not fulfill diagnostic criteria of RA or OA (GZ-group). Blood samples were obtained …

In-Silico Study Of Rosmarinic Acid Roles In Inhibiting Breast Cancer Progression, Ngakan Putu Krishna Mahayana, Ngurah Bagus Agung Surya Nanda Jayesvara Dwi Sutanegara, Made Dwinanda Prabawa Mahardana, Desak Made Wihandani

BioMedicine

Background: Breast cancer is the highest cancer incidence in the world. Chemotherapy is currently one of the main breast cancer treatments besides surgery. It is capable of evolving to become resistant to chemotherapy agents. Chemotherapy also has significant side effects. Rosmarinic acid could become an anti-cancer agent candidate for the treatment of breast cancer, but its molecular mechanism is still unclear.

Aim: This study aimed to clarify the molecular mechanism of rosmarinic acid anti-breast cancer properties via an in-silico study.

Methods: Web-based screening tools such as SwissTargetPrediction, Similarity Ensemble Approach (SEA), and TargetNet were used as initial screening. From web-based …

Unveiling Role Of Oncogenic Signalling Pathways In Complicating Breast Cancer, Acharya Balkrishna, Sagar Kumar, Rohan Malik, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Rashmi Mittal

BioMedicine

Heterogeneous nature of breast cancer has significantly affected the overall survival, disease free survival and progression free survival amongst the diseased individuals. Metastasis of cancerous cells to distant sites including bone, lungs, liver, lymph node and others have further exhilarated the adverse effects. However, ER, PR and HER-2 are responsible for normal physiological development of women but in altered conditions they may act as initiator or progressor and so far 5 subtypes of disease have been identified. Alteration of pro-survival, pro-proliferative and anti-apoptotic pathways including JAK/STAT, MAPK,

PI3K/AkT/mTOR, NF-κB, BCL2 and several others have induced oncogenic events including epithelial-mesenchymal transition, …

Mini-Review Of Clinical Data Service Platforms In The Era Of Artificial Intelligence: A Case Study Of The Ihi Data Platform, Yu-Ting Lin, Ya-Chi Lin, Hung-Lin Chen, Che-Chen Lin, Min-Yen Wu, Sheng-Hsuan Chen, Zi-Han Lin, Yi-Ching Chang, Chuan-Hu Sun, Sheng-Ya Lu, Min-Yu Chiang, Hui-Chao Tsai, Mei-Ju Shih, David Ray Chang, Fuu-Jen Tsai, Hsiu-Yin Chiang, Chin-Chi Kuo

BioMedicine

In the past two decades, healthcare organizations have transitioned from the early stages of digitization and digitalization to a more comprehensive process of digital transformation, a shift significantly accelerated by the advent of artificial intelligence (AI). Consequently, the development of high-quality clinical data warehouses, derived from electronic health records (EHRs) and enriched with multidomain data, such as genomics, proteomics, and Internet of Things (IoT) information, has become essential for the creation of the modern patient digital twin (PDT). This approach is critical for leveraging AI in the evolving landscape of clinical practice. Leading medical centers and healthcare institutions have adopted …

Robotic Spine Surgery - Surgical Technique And Nuances For Improving Safety, Mun Chun Lai, Pirateb Paramasivam Meenakshi Sundaram, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh

BioMedicine

The integration of robotic technology into spinal surgery has led to a remarkable transformation, offering improved precision and safety. The “CT-Fluoro merge” and “Scan-and-Plan” methods for pedicle screw application promise numerous advantages, minimizing risks associated with traditional approaches. Our early series of patients who underwent robot-assisted pedicle screw placements for various indications, predominantly lumbar spondylosis, revealed no complications related to screws, neurological deficits, or unplanned returns to the operating theatre, thus emphasizing the safety and effectiveness of the robot. Studies have consistently demonstrated the superiority of robot-assisted pedicle screw placement in terms of accuracy, with decreasing rates of technical issues …

Artificial Intelligence-Driven Prediction And Validation Of Blood-Brain Barrier Permeability And Absorption, Distribution, Metabolism, Excretion Profiles In Natural Product Research Laboratory Compounds, Jai-Sing Yang, Eddie Tc Huang, Ken Yk Liao, Da-Tian Bau, Shih-Chang Tsai, Chao-Jung Chen, Kuan-Wen Chen, Ting-Yuan Liu, Yu-Jen Chiu, Fuu-Jen Tsai

BioMedicine

Introduction: Our previous research demonstrated that a large language model (LLM) based on the transformer architecture, specifically the MegaMolBART encoder with an XGBoost classifier, effectively predicts the blood-brain barrier (BBB) permeability of compounds. However, the permeability coefficients of compounds that can traverse this barrier remain unclear. Additionally, the absorption, distribution, metabolism, and excretion (ADME) characteristics of substances obtained from the Natural Product Research Laboratory (NPRL) at China Medical University Hospital (CMUH) have not yet been determined.

Objectives: The study aims to investigate the pharmacokinetic ADME properties and BBB permeability coefficients of NPRL compounds.

Materials and Methods: A …

Juxtaposition Of Bone Age And Sexual Maturity Rating Of The Taiwanese Population, Wen-Li Lu, Chung-Hsing Wang, Yi-Chun Lin, Fuu-Jen Tsai

BioMedicine

Background Bone age (BA) and sexual maturity rating (SMR) are the imperative measures in assessing adolescent growth and development. However, studies indigenous to the Taiwanese population with regard to the association of SMR and BA in adolescence is scarce. This study attempts to utilize the AI-assessed BA results to establish a relationship between BA and SMR of the Taiwanese population in regard to the initiation of puberty. Materials and methods The electronic medical records with examinations of bone age assessed between January 1st 2019 and December 31st 2019 were reviewed retrospectively. Records of the same individuals were retained only the …

Artificial Intelligence (Ai)-Powered Bibliometric Analysis Of Global Trends In Mesenchymal Stem Cells (Mscs)-Derived Exosome Research: 2014-2023, Shih-Chang Tsai, Bing-Han Wan, Fuu-Jen Tsai, Jai-Sing Yang

BioMedicine

Introduction: In recent years, significant progress has been made in regenerative medicine, specifically in using mesenchymal stem cells (MSCs) due to their regenerative and differentiating abilities. An exciting development in this area is the utilization of exosomes derived from MSCs, which have shown promise in tissue restoration, immune system modulation, and cancer treatment.

Objectives: This study aims to analyze global research trends and the academic impact of MSCs-derived exosomes from 2014 to 2023, providing a comprehensive overview of this emerging field.

Materials and Methods: The Web of Science database selected 948 relevant publications from 2014 to 2023. Artificial intelligence …

Application Of Machine Learning To Identify Risk Factors For Outpatient Opioid Prescriptions Following Spine Surgery, Alexander Bouterse, Andrew Cabrera, Adam Jameel, David Chung, Olumide Danisa

BioMedicine

Introduction: Spine surgery is a common source of narcotic prescriptions and carries potential for long-term opioid dependence. As prescription opioids play a role in nearly 25% of all opioid overdose deaths in the United States, mitigating risk for prolonged postoperative opioid utilization is crucial for spine surgeons.

Purpose: The aim of this study was to employ six ML algorithms to identify clinical variables predictive of increased opioid utilization across spinal surgeries, including anterior cervical discectomy and fusion (ACDF), posterior thoracolumbar fusion (PTLF), and lumbar laminectomy.

Methods: A query of the author’s institutional database identified adult patients undergoing …

Advanced Whole Transcriptome Sequencing And Artificial Intelligence/Machine Learning (Ai/Ml) In Imiquimod-Induced Psoriasis-Like Inflammation Of Human Keratinocytes, Lii-Tzu Wu, Shih-Chang Tsai, Tsung‑Jung Ho, Hao-Ping Chen, Yu-Jen Chiu, Yan-Ru Peng, Ting-Yuan Liu, Yu‑Ning Juan, Jai-Sing Yang, Fuu-Jen Tsai

BioMedicine

Introduction: Although the HaCaT keratinocyte model has been used in previous research to study the effects of anti-psoriatic agents, there is still a lack of comprehensive understanding of the mechanism of imiquimod (IMQ)-induced proliferation and signal transduction in psoriasis-like keratinocytes.

Objectives: This study aimed to investigate the molecular mechanisms and pathways associated with psoriasis-like inflammation caused by IMQ in human keratinocytes.

Materials and Methods: HaCaT cells were exposed to different concentrations of IMQ to induce inflammation similar to that observed in psoriasis. Cell viability was evaluated using the MTT assay and cell morphology was examined using phase-contrast …

Machine Learning-Guided Differential Gene Expression Analysis Identifies A Highly-Connected Seven-Gene Cluster In Triple-Negative Breast Cancer, Hany Ghazal, El-Sayed A. El-Absawy, Waleed Ead, Mohamed E. Hasan

BioMedicine

Background: One of the most challenging cancers is triple-negative breast cancer, which is subdivided into many molecular subtypes. Due to the high degree of heterogeneity, the role of precision medicine remains challenging. With the use of machine learning (ML)-guided gene selection, the differential gene expression analysis can be optimized, and eventually, the process of precision medicine can see great advancement through biomarker discovery.

Purpose: Enhancing precision medicine in the oncology field by identification of the most representative differentially-expressed genes to be used as biomarkers or as novel drug targets.

Methods: By utilizing data from the Gene Expression Omnibus (GEO) repository …

Integrating Natural Product Research Laboratory With Artificial Intelligence: Advancements And Breakthroughs In Traditional Medicine, Jai-Sing Yang, Shih-Chang Tsai, Yuan-Man Hsu, Da-Tian Bau, Chia-Wen Tsai, Wen-Shin Chang, Sheng-Chu Kuo, Sheng-Chu Kuo, Chien-Chih Yu, Yu-Jen Chiu, Fuu-Jen Tsai

BioMedicine

The Natural Product Research Laboratory (NPRL) of China Medical University Hospital (CMUH) was established in collaboration with CMUH and Professor Kuo-Hsiung Lee from the University of North Carolina at Chapel Hill. The laboratory collection features over 6,000 natural products worldwide, including pure compounds and semi-synthetic derivatives. This is the most comprehensive and fully operational natural product database in Taiwan. This review article explores the history and development of the NPRL of CMUH. We then provide an overview of the recent applications and impact of artificial intelligence (AI) in new drug discovery. Finally, we examine advanced powerful AI-tools and related software …

Correction Notice To: The Effect Of Nigella Sativa Oil On The Prevention Of Phlebitis Induced By Chemotherapy: A Clinical Trial, Niaz Behnamfar, Zohreh Parsa Yekta, Faraz Mojab, Seyyed Mohammad Kazem Naeini

BioMedicine

No abstract provided.