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Articles 1021 - 1022 of 1022
Full-Text Articles in Medical Sciences
Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash
Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash
All ETDs from UAB
Failure to reduce the number of cancer deaths over the last 50 years is due to the inability to selectively target metastatic disease. Recently, the KISS1 metastasis suppressor has emerged as a promising molecular agent for the management of metastatic disease. Although KISS1 has been implicated in the regulation of the metastatic phenotype in human cancers and in in vivo mouse models, little is known about its mechanism. Recent evidence suggests that KISS1 is a neuropeptide that is processed and secreted to interact with its cognate receptor GPR54 in the hypothalamus to trigger puberty and maintain the reproductive state. However, …
Thermodynamic Consequences Of Dna Base Modifications And Ligand-Dna Interactions., Rachel Hutchins Graves
Thermodynamic Consequences Of Dna Base Modifications And Ligand-Dna Interactions., Rachel Hutchins Graves
All ETDs from UAB
The thermodynamic effects of alterations of the DNA duplex by DNA base modifications or ligand binding are investigated by a combination of spectrophotometric and calorimetric methods. Examination of the effects of substituent modification on the DNA binding energetics of the anticancer agent AAC (Y-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide) indicated that DNA binding affinities and energetics were enhanced upon substitution at the C5 position on the chromophore of the drug with a variety of chemical groups. A correlation between enthalpies of DNA binding and anticancer activity was evident.The impacts of DNA base modifications, including cytosine arabinoside, deaminated cytosine, and abasic sites, on the thermodynamics of …