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Western University

Undergraduate Student Research Internships Conference

COPD

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Ex-Smokers With And Without Copd: Investigating Ct Pulmonary Vascular, Airway, Pulmonary Artery And Aorta Measurements, Vedanth Desaigoudar, Paulina V. Wyszkiewicz, Alexander M. Matheson, Maksym Sharma, Marrissa J. Mcintosh, Harkiran K. Kooner, David G. Mccormack, Grace Parraga Aug 2022

Ex-Smokers With And Without Copd: Investigating Ct Pulmonary Vascular, Airway, Pulmonary Artery And Aorta Measurements, Vedanth Desaigoudar, Paulina V. Wyszkiewicz, Alexander M. Matheson, Maksym Sharma, Marrissa J. Mcintosh, Harkiran K. Kooner, David G. Mccormack, Grace Parraga

Undergraduate Student Research Internships Conference

RATIONALE: Pulmonary hypertension is characterized by increased pressure in the pulmonary artery, and is a key contributor to worsening symptoms in individuals with chronic obstructive pulmonary disease (COPD). The pulmonary artery to aorta diameter ratio (PA:Ao), measured using computed tomography (CT), is a biomarker of pulmonary hypertension; however, longitudinal changes in this measurement and its relationship to pulmonary vascular and airway structural changes is not well understood. Our objective was to investigate longitudinal changes in PA:Ao and its relationship with CT pulmonary vascular and airway abnormalities, airflow limitation and exercise-capacity.