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Metabolomic Approach For Earlier Diagnosis Of Cisplatin-Induced Acute Kidney Injury, Steven Xiu, James (Yong Jin) Lim
Metabolomic Approach For Earlier Diagnosis Of Cisplatin-Induced Acute Kidney Injury, Steven Xiu, James (Yong Jin) Lim
Undergraduate Student Research Internships Conference
Cisplatin is a chemotherapeutic agent complicated by its dose-limiting nephrotoxicity. This commonly presents as acute kidney injury (AKI), which is characterized by a reversible decline in kidney function. AKI is currently diagnosed by increased serum creatinine (SCr) levels, but this rise in SCr is delayed limiting diagnosis to when significant renal damage has already occurred. Currently, there are no known biomarkers capable of predicting or diagnosing early-stage cisplatin-induced AKI. Metabolomics was used to identify novel predictive/early diagnostic biomarkers for cisplatin-induced AKI. We hypothesized that differences in metabolic profiles will be able to predict and/or diagnose cisplatin-induced AKI prior to rise …